Has Mounjaro stopped working for anyone?

[Waitingforthesunnydays]

I’ve been on MJ since May. Started out with a bmi of 30 and 4 stone to lose. At first it was a breeze, I had minimal side-effects and good appetite suppression and I lost weight pretty quickly. I started on 2.5mg and increased every couple of months, I’m now on 10mg and have been for 6 weeks. However since I went up to 7.5 (which I was only on for a month before going up to 10) I’ve felt it’s become less and less effective. Going up to 10 made no difference and now I feel like I have an almost normal appetite. I’ve lost 3 stone but my weight stayed the same for about 2 months and in the last month I’ve put on about 4lbs. I’m planning on going up to 12.5 on the next order but I don’t think it’ll make much difference as the last increase didn’t. Has anyone else experienced this? What did you do? Did you find 12.5 or 15 to be effective if 10 wasn’t?

I’m on 7.5mg and have been for about 6 weeks and appetite suppressant lasts for about 3 days and then I’m constantly hungry again. 2.5and 5 was the best doses for me but also it was new to my body back then. I do think that our bodies get used to all medications eventually and they become less effective.

You haven't stated your start weight and what percentage 4st loss is, but yes it's very common to plateau at around 20% to 25% loss, especially if you aren't implementing other lifestyle changes (i.e. better diet, walking, gym work etc).

I started March last year - have lost 2 stone, about 10lbs to be no longer overweight. I have stalled for the last 2 months on the scales however I’m losing inches. Am realistic they I need to tighten up the diet and move more ( and drink less) to get the scales moving again. Could you be the same?

I had no suppression on 2.5mg then it kicked in 5mg and I moved up the doses staying at 10mg for 4 months then 12.5 was nothing and 15 is working well. I’d have thought 12.5 mg was water. Stalled completely for 6 weeks. Everyone’s different but move up the doses til you find the sweet spot.

My starting weight was 13st 13lbs and my goal weight is 10st, so my goal is almost 4 stone. So I’m now 11st 6lbs and I seem to have totally plateaued (and gone up a bit) at this weight, I’ve been around this for about 3 months now. It’s really annoying cos I’m doing the exact same amount of exercise as I always have been (strength training 3 times a week, lots of walking and playing football once a week). My bmi is around 23 so I’m not overweight anymore but I’d really like to lose another stone. Tbf I know I’m not being as careful with my diet and I’m definitely eating more volume-wise so maybe I just need to try a bit harder, but I miss the days when I didn’t even have to try and I’d be happy with 4 carrots and a small bowl of lentil soup for dinner 🤣

The main problem is that the food noise is back. I’m craving takeaways and a pizza for dinner whereas before those cravings weren’t there and I was really enjoying eating healthily

So that's 23% lost - so yeah - right in the window where weight loss stalls.

Another st would be 35% in total - that's a very high for weight loss jabs and possibly unattainable.

I would say you are in the maintenance phase now and yes, food noise will return so this is when you need to get very strict with diet and unfortunately willpower again becomes the main factor in maintaining your new weight,

I’ve lost 23kg (23%) and loss has slowed right down, interestingly I am the same weight now I was before I got pregnant 11 years ago which I had been for most of my adult life. I’m wondering if this is actually my ‘set point’ and low dose MJ has put me back there. I’m still at a BMI of 24 theoretically could lose loads more but I don’t think I will and I don’t think it would be sustainable if I did. Right now this feels sustainable

Yes, 2.5 worked for a month but I’ve increased to 7.5 and tbh I am as hungry as ever. Using my last 2 doses, not buying any more.

I agree with this, you may need to accept that you are now in maintenance and that a BMI of 23 is where you will stay.
Thats a perfectly healthy BMI to remain at, focus on the health benefits that you've achieved rather than a possibly unrealistic idea of how you want to look. Well done!

Well this happened to me, and I realised I had to start properly tracking. I also realised I was under eating protein when I started tracking, so I really focused on increasing that, and it became far easier to maintain a calorie deficit when I was eating more protein and prioritising it more.
I see your next post talks about food noise coming back. It will do, if you eat a high carb high sugar diet. I noticed this every time I had a 'slip' in the first 6 months- for several days after I could have eaten a proverbial horse. Since changing my eating patterns I have lost another stone with very little effort and I'm now aiming to reduce my dose and maintain.

I’ll have been on it two years in April. Staring somewhere mid 14. Got to 10st 10 (wanted to lose another stone) and plaster for a year. Slowly but surely a stone has gone back on. I went to highest dose. Tried dropping back to 7.5,… I now cannot seem to get this weight to shift at all despite still being actively on. I actually don’t know what to do. Scared to be without it… scared to keep paying for something that isn’t helping me weight wise (I’m sure it’s still doing something rather than nothing though… )

I have stalled with 27% of my body weight lost but still two stone to go. I have moved much slower through the doses than you, OP, as for a long time I couldn't tolerate 5mg without terrible D&V. I lost five stone taking less than 5mg for a year. I was pretty pleased from a financial pov not to be moving up, I have to say!

However, since the summer I have only lost five more pounds and gained two over Christmas that simply will not shift. I went to 5mg in November with no side effects but no loss either, and am now on 7.5mg. I am both hungry and terribly nauseous (reminds me of morning sickness) but have a bit more energy and focus again - this drained away as the lower doses became less effective and I was feeling more sluggish with a major afternoon slump every day. I still am seeing no movement on the scales. I have reduced portion sizes again - these had been creeping up but now I am having more suppression and able to cut those back down.

I have a personal trainer and do Pilates as well as strength training, also daily walks but if I am honest I have been much more sedentary in these dark and rainy December/January weeks. I have hit diet fatigue and cannot be bothered to think of tasty, healthy meals so I'm rotating the same boring foods and that means I'm much more likely to feel snackish. I am so much better in the warmer months making interesting salads, but when it's so cold I really lean towards stodgier carbs.

For me, I really do think the time of year is playing a major role but I am consoling myself on two levels. Firstly, I expect to be on these meds for life so I am not in a rush to lose all the weight as fast as possible and come off them. Secondly, in my former life, the idea that I'd only gain 2lbs over Christmas and then maintain through January rather than continuing to put weight on would be impossible to imagine. It's frustrating to find myself in maintenance when I'm not particularly close to goal, but it's much better than being five stone heavier and still gaining. If I can hold steady now, I know the weight will start moving again. I may gradually increase up to 10mg but I am cautious due to my history of side effects and the nausea I'm currently experiencing.

Psychologically, I also feel this huge relief that I'm under a BMI of 30. I started with a BMI of 42! I am still at 29, but it does feel like a bit of breathing space nonetheless.

I have major surgery scheduled later in the year, and am worried how much I may regain while out of action afterwards as I recover, so my goal is to build strength and muscle to whatever degree I can before then. But I fully expect this to be a lifelong journey and there will be bumps and stalls along the way.

I have gone up to 7.5 but down to 5mg again. 5mg works for me. I have never had any rapid weight loss it always been 1-2lbs a week.

When I was stalling I stopped for two weeks. Put everything into my fitness pal and worked out from there what I needed to eat to loose weight being mindful.of having MJ in my system and listening to how hungry I felt.

You can't do this long term just using the jabs to control the calories.

I have had a few weeks off the jabs for holidays etc. That's not recommended. But one day I'm going to stop completely. I was surprised that it didn't take much to be 100-200 calories over every day and the only way to stop that was to put in a few very healthy lean days every week.

How are some people looking dead dead skinny on it tho

Maybe they didn't have an obesity problem in the first place?

@JessicaRabbit23 which people do you know who look “dead dead skinny” on Mounjaro?

You mean like celebrities? They aren't fat to start with!

Take some time today to really think about your lifestyle during this period when the MJ hasn’t been as effective.

• are you drinking plenty
• are you getting enough sleep
• are your still eating less calories than your TDEE, bearing in mind your calorie needs reduce as you lose weight so you need to reduce intake accordingly to continue to lose
• are you eating enough protein, fibre and fat to feel satiated
• are you doing exercise, particularly weight/resistance based

If there are any areas where your answers to the above could be improved then that gives you your focus to try to get things back on track.

MJ is fantastic, but it isn’t a miracle cure and you need to work with it, it is designed to work on your hormones to increase insulin production and sensitivity but if you are eating high GI foods then you’ll be working against it. It is designed to slow your digestion and help you to feel full but if you arent getting enough fibre and water you’ll be working against that. Sleep or lack of it affects the hormones that make you feel hungry and so on.

Evaluate your current lifestyle before upping your dosage.

Because they are using it alongside an eating disorder to facilitate an unhealthily low calorie intake. Anyone can look dead skinny if they can exist on 500 or less calories a day for a while.

I’ve been on my since January last year and have lost 7st. I’m on 12.5mg and have been for a few months. Still losing a couple of pounds a week. Although the week before I’m due on, I don’t lose anything. I plateaued on 10mg, I wish I had stayed on 7.5mg as it was really effective for me. Stick at it.

I started Mounjaro at 19 stone, I'm now 16 st 12 so just over two stone weightloss. 7.5mg at the moment, and I get suppression and sulpher burps for about three days, then from the start of the week the supression goes away gradually, and Wednesday is the day when I do want to eat more, but my stomach fills up quickly though, and I do feel full. I've not been a good eater of vegetables, so I found a food company that does meals with prepared vegetables and I'm going to start eating them next week from tomorrow, so I'll see whether that does anything to quick start the weightloss again. Scales have been mainting for a few weeks.

I do think time of year doesn't help when you started during the warmer months and saw success with tempting salads and protein. I'm waiting for sunshine and warmth again and hoping that will help with the types of food I crave

I haven’t read everybody else’s answers but I’m 7 stone down on it. Last year 10mg stopped working for me so I went up to 12.5 for a few weeks and literally nothing wasn’t working at all. I did a week of 15 and again nothing. Then I randomly decided to do 10mg and see what happened. And 10mg hit for me. I learned about this from a lady who was coming back down and was worried but said coming down doses her suppression was better than ever! Worth a go and cheaper ££. I also find when I use an insulin needle it works so much better than the one for on the pen.

I think sometimes people expect the jabs to do all the work but you have to do the maths too.

The number of cals needed to lose/maintain/gain weight depends on your current weight not your starting weight. As you lose weight you have to continue to decrease your calorie intake to continue to lose.

Unfortunately this leads to people needing a higher and higher dose to keep going and either maxing out the dose or the cost or the side effects. Without a long term strategy to keep the calorie intake right down the weight loss is always going to plateau.....or worse.