Advice on dosing

[Kazzaa46]

Hi, looking for advice from anyone with personal experience please.

I’ve done 4×2.5 mg, 4×3.75 mg, and am due my 4th 5 mg dose today. I’ve had almost no side effects except constipation.

On 5 mg, days 2–4 give me too much appetite suppression, but days 5–7 give me almost none. After my 3rd 5 mg dose, I oddly at this point in my journey got sudden nausea on days 2–4 for the first time, which disappeared by day 5 when the food noise returned.

I don’t want to move to 7.5 mg because the early-week suppression is too strong.

Could splitting doses (e.g., 2.5 mg twice weekly or 3.5 mg every 5 days) work better?

It might, but honestly I don't see a major issue with your pattern - it's ok to eat more some days and less on others. You don't need to have the same suppression level every single day, the drug doesn't work like that.

I wouldn't do split dosing to try to fix something is working the way it is expected to, plus no one knows the long term risks of using this medication more frequently that its standard dosing schedule.

How does your diet look? Are you meeting calorie deficit and macro targets? Are you eating enough protein with every meal? Are you working with Mounjaro by reducing the foods that cause cravings simple carbs/sugar/sweeteners/UPF? Are you getting enough water - at least 2L?

You might find the high suppression you are still experiencing (not everyone still gets this after the first 2-3 months) and lack of nutrition is making your body respond more as the medication wears off as the week progresses. This is okay, you can calorie cycle and have more calories towards the end of the week, but make them protein and fiber rich so you are more satisfied and it keeps cravings at bay.

I have 4mg every 5 days with good pretty consistent suppression of appetite and food noise.