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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

December 25 starters thread?

831 replies

cobblers00 · 28/11/2025 09:39

Is there one yet? If not, should this be it? I’m starting tonight, so officially November, but hey! Am so nervous, woke up early this morning with anxiety. Would love tips from anyone who has started before on what / how to eat on first few days..I’m really concerned about debilitating side effects- should you just listen to your body or force yourself to eat chicken?! I keep seeing all these insta posts about eating protein!!

OP posts:
Thread gallery
18
SexyFrenchDepression · 06/01/2026 15:29

Gardener82 · 06/01/2026 15:25

It’s so bloody confusing, I’ve been using my fitness pal and that told me I should be eating 1200 calories today to lose 2lb per week.
Just tried another site that says around 800.

Yes MFP seems to give a really high amount. I used the one you have used in your screenshot, then someone on here recommended another and it came out at 977 cals for losing around 1.5-2lb. I'll try and find the link. I was probably around 68kg then, maybe slightly more. I am now 65kg but havent changed my cals as I'm often slightly under and still losing a decent amount anyway.

Foodylicious · 06/01/2026 17:53

ChristmasCalsDoCount · 06/01/2026 08:44

Is anyone else experiencing extreme coldness as a side effect? I know the weather has a part to play in this but the level of coldness I’m feeling inside with the heating on, layered up and under a blanket is unreal.
Not complaining if this is the worst side effect I get, just wondering if anyone else is the same?

Yes!
I thought it was just me.
I just can't get warm alot of the time.
Even when I can tell its warm, im cold.
I will admit today's been a bit better. Im mid week 4 now.

user1479317972 · 07/01/2026 08:02

Hi on week 2 MJ and have terrible upset stomach. I can’t even leave the house today. Does this disappear? Any advice on what to eat? I’ve been eating really healthily, no alcohol or greasy foods. I’ve been having a protein powder and suspect this might have contributed to my stomach issues :(

SexyFrenchDepression · 07/01/2026 08:48

user1479317972 · 07/01/2026 08:02

Hi on week 2 MJ and have terrible upset stomach. I can’t even leave the house today. Does this disappear? Any advice on what to eat? I’ve been eating really healthily, no alcohol or greasy foods. I’ve been having a protein powder and suspect this might have contributed to my stomach issues :(

Edited

I had the same in week 1 or 2, can't remember exactly when now, it lasted less about 24 hours, started in the middle of the night and was horrible but not really that frequent luckily. A few people on here have said the same on here. I havent had it since though. Mostly the opposite!

user1479317972 · 07/01/2026 10:55

SexyFrenchDepression · 07/01/2026 08:48

I had the same in week 1 or 2, can't remember exactly when now, it lasted less about 24 hours, started in the middle of the night and was horrible but not really that frequent luckily. A few people on here have said the same on here. I havent had it since though. Mostly the opposite!

I just realised it might be something in my protein shakes. Full of sucralose !

SexyFrenchDepression · 07/01/2026 11:08

user1479317972 · 07/01/2026 10:55

I just realised it might be something in my protein shakes. Full of sucralose !

Have you tried the clear whey? I have found I feel much better with those.

user1479317972 · 07/01/2026 11:16

SexyFrenchDepression · 07/01/2026 11:08

Have you tried the clear whey? I have found I feel much better with those.

Will give that a go thanks :)

StrongGirlsLift · 07/01/2026 11:27

That sounds rough, user, hope you feel better soon, and that the shakes are the culprit!

I thought some of you might be interested in this article on coming off GLP1 (I note the author is in a paid consulting role for the egg industry though!)

theconversation.com/how-eggs-can-help-you-come-off-wegovy-cracking-the-problem-of-weight-regain-271883?utm_medium=article_native_share&utm_source=theconversation.com

StrongGirlsLift · 07/01/2026 11:30

I have been suffering with headache/migraine almost constantly since late December and don’t know whether to blame the jabs. Gah.

I have however had something of a whoosh and have now lost 5% of my body weight in just over 5 weeks, so am feeling good about that! Drinking lots of water and eating pretty clean since the holidays, and am feeling much better more “regular” now. Phew.

Colinthedaxi · 07/01/2026 11:50

I did my fourth injection yesterday but I have been randomly spacing them out (10 days, 12 days, 9 days) had been getting good suppression and was down 4kg. Fourth injection yesterday and I’m starving today and my weight has shuffled back up. Have another 2.5 syringe which I will take properly then might try 5mg. Feel really good though, belt has moved up two holes and clothes are a little looser so still feel it’s “working” when the scales don’t agree.

Frillysweetpea · 07/01/2026 12:24

Re the tummy issues I was fine on 2.5 mg but have had intermittent problems with 5 mg. I'm now on week 2 of that and I had severe constipation for the first week requiring a Movicol clear out regime. The following week has been better but I have had intermittent abdominal cramps and a lot of wind at both ends on random evenings. It's not happening often enough to put me off but it's not pleasant when it happens- I usually have to go and lie down for a bit. But I'm just under a stone down, having started late November so that is very motivating. I've lost interest in alcohol as well as food which is a bonus. ☺️

BelleEpoque27 · 07/01/2026 15:05

user1479317972 · 07/01/2026 08:02

Hi on week 2 MJ and have terrible upset stomach. I can’t even leave the house today. Does this disappear? Any advice on what to eat? I’ve been eating really healthily, no alcohol or greasy foods. I’ve been having a protein powder and suspect this might have contributed to my stomach issues :(

Edited

I get upset stomach from 'high protein' processed stuff - I noticed this even before I started Mounjaro. I've had it from a Skyr high protein yogurt, and from protein milkshakes like Huel or similar. I don't tend to eat them now, other than a Huel occasionally if I really can't face eating.

Foodylicious · 07/01/2026 18:06

Well Im pleased to say the nausea is now pretty much non existent.
Scales have also shifted a bit again, so now 7lbs down from starting 3.5 weeks ago.
Appetite suppression is working well.

Florrieboo · 07/01/2026 18:46

I had my 4th 2.5 dose on Tueday night and the nausea all day Wednesday was terrible. I was in the car with my son and had to take a sick bag I was so sure I was going to throw up. Also zero appetite at all for the whole day and I had to force myself to eat some chicken for protein but I had such an ick to it. Hopefully today is better yesterday took me by surprise. It has convinced me to stay on 2.5

cobblers00 · 07/01/2026 18:59

It’s so weird how the side effects pop up unexpectedly. Nausea is the worse too. I’ve been really lucky so far & only really been nauseous when I’ve overindulged. Constipation is a problem but manageable. I’ve ordered my next dose now as wasn't sure how long it would take.. opted for 2.5 for a third month too as working ok & got a good price from pharmacy4u. Once I sent the proof of existing prescription (which they accepted in form of screenshots & emails!) it was approved super quick & is arriving tomorrow! I’m also going to try & extract the golden dose from my current pen this month & have ordered some syringes to do that. Pleased with progress:
sw: 77kg (28/11)
cw: 71.4kg
almost a stone down in 6wks!!
I am definitely feeling hungrier but would rather take 2.5mg every 6 days & try to build my own willpower up than up dose to 5mg at this point I think.
Alongside all the physical changes I feel so much sharper & just ‘lighter’ mentally since starting on the medication. Has anyone else noticed this?

OP posts:
Colinthedaxi · 08/01/2026 14:58

“I feel so much sharper & just ‘lighter’ mentally since starting on the medication. Has anyone else noticed this?”

Didn’t reply yesterday as I was having an Eeyore moment but yes I feel much lighter in general, house is tidier, more bounce in step.

OH does the shopping, I hate it (shopping, not that he does it, I love that he does it!) how in the hell do I get him to stop buying thirty tons of Carbs?!!

Tammy214 · 08/01/2026 16:09

Hmm i think i havent been priming properly before each dose, first one i did right i think but after wards i was worried i was wasting too much liquid.
will have to remember to prime properly tonight when i do do the injection as i know there is enough to do it right

cobblers00 · 08/01/2026 16:14

only a tiny bit of liquid comes out when I prime each time, just a drop on top of the needle.. what have you been doing ? it can be confusing I know - I didn’t leave the pen in for 5 seconds after jabbing today.. it says you’re meant to hold it there after injecting but I just pulled it out immediately.. can’t see it’ll have a big effect as all the liquid went in 🤷🏼‍♀️

OP posts:
SexyFrenchDepression · 08/01/2026 16:26

Tammy214 · 08/01/2026 16:09

Hmm i think i havent been priming properly before each dose, first one i did right i think but after wards i was worried i was wasting too much liquid.
will have to remember to prime properly tonight when i do do the injection as i know there is enough to do it right

There should just be a small drop. I managed to squirt out loads on my last pen somehow, have managed to do it properly this time. Some of the YouTube videos are helpful as show you what it should look like.

SexyFrenchDepression · 08/01/2026 16:30

cobblers00 · 08/01/2026 16:14

only a tiny bit of liquid comes out when I prime each time, just a drop on top of the needle.. what have you been doing ? it can be confusing I know - I didn’t leave the pen in for 5 seconds after jabbing today.. it says you’re meant to hold it there after injecting but I just pulled it out immediately.. can’t see it’ll have a big effect as all the liquid went in 🤷🏼‍♀️

I think the 5 seconds is whilst you are injecting not after you have finished, so slowly counting to 5 as you push the plunger in rather than a quick inject?

Tammy214 · 08/01/2026 16:41

Panic over!
Before i chucked the finished 2.5 pens i checked that the plunger for a better word, was inline with the correct marks. However there was quite a bit left from the last marker to the tip and therefore seems lot of liquid.

looking at the 5mg pens, the markers are closer to the end so less liquid will be left. Initially i thought this meant the pen was shorter (cant compare i chucked the first ones), but not sure.
maybe its the volume /clicks for the dosage, or there is less liquid for priming. Maybe its because they think you might need more scope for error when first using the 2.5 pens hence they add a bit more, i dont know

SilenceInside · 08/01/2026 17:01

@Tammy214 The pens are all the same size and have the same markings on the glass vial. They all contain the same amount of liquid, 2.4ml plus another 1ml or so for priming. Once you’ve done 4 normal doses, what is left is around 0.6 to 0.9ml depending on how much comes out when priming each of the 4 doses. When you prime, you turn the pen 2 clicks which means a maximum of 0.02ml comes out each time.

I have been using Mounjaro for 18 months and am very familiar with the pens, I also have all my old empty pens to hand if I need to check them for any reason.

Tammy214 · 08/01/2026 19:05

well i have to disagree because the markings on the 2.5 i recieved left more liquid, now that could be a shape of the pen top but the markings where further from the top. i wish i had kept a picture of the finished 2.5 to show you, but i am not stupid i know there was a difference in the markings at the top. why i dont know, which is why initially i panicked.

SilenceInside · 08/01/2026 19:15

Honestly, they really are all the same. I will take a photo of all of mine and post it in a bit.

Florrieboo · 08/01/2026 19:22

As far as I know they only make one type of pen (so far) and they use it for all the concentrations. There is talk of a newer pen coming with less waste so I guess that might be what you got?

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