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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Should I split dose

15 replies

Iloveacuppatea · 10/11/2025 13:27

Hi, I have just started on mounjaro 2.5mg and had really bad diarrhoea and vomiting this morning. I’m fine now (apart from wind pains) and was hungry so had breakfast. I’m sipping water too. However, wondering on 2 things! I don’t seem to have any suppression yet, although it’s less than 24 hours since I injected…..and what do I do about the next dose? Am I best to split it as I don’t want to go through those side effects every week. If I do take half (30 clicks from the 2.5 pen) next Sunday, when would you recommend I take the next? I know it’s not licensed for this but I’m not wasting it and really want to stay on it if I can. Thank you xx

OP posts:
PearlTeapot · 10/11/2025 16:44

I took 1.25 for 4 weeks :) do that if the side effects are too much.

ThirdStorm · 10/11/2025 17:12

I'd first suggest you review your diet, what are you eating? The only time I had those side effects was eating too much or eating fat. I had to eat very plainly for the first few weeks think grilled chicken and plain veg.

Iloveacuppatea · 10/11/2025 18:33

Hi, did you lose weight doing this? And did you wait a full week before taking the next dose! Thanks x

OP posts:
Thistleton · 10/11/2025 19:41

I’ve been splitting my dose since I started (ie injecting twice a week, Monday mornings and Thursday evenings). I started very low (1.25mg / week) to avoid side effects and built up slowly. Now on 5mg / week split over two doses. Have lost weight slowly but consistently.

hoarahloux · 10/11/2025 20:00

As you've just started, perhaps see how you go next week.

ThirdStorm · 10/11/2025 20:05

Iloveacuppatea · 10/11/2025 18:33

Hi, did you lose weight doing this? And did you wait a full week before taking the next dose! Thanks x

Yes 5 stone in 4 months all on 2.5mg with 7 day spacing.

weericky · 10/11/2025 20:19

What did you eat?

Calypsocuckoo · 10/11/2025 20:20

You have only just started and some side effects are expected, I think you should follow the instructions and do it as prescribed for the few few months whilst you get used to it. The appetite suppression does come in after a few days but it can take until the next dose. I have had worst side effects when I have fatty or rich foods, so maybe stick to bland food like chicken, rice, veg whilst you adjust.

PearlTeapot · 10/11/2025 20:46

Iloveacuppatea · 10/11/2025 18:33

Hi, did you lose weight doing this? And did you wait a full week before taking the next dose! Thanks x

I lost 12lb in that first month on 1.25 :)

Iloveacuppatea · 11/11/2025 12:23

I don’t really eat fatty foods, but yes I will avoid like the plague. have mild nausea today but have eaten healthily even though I don’t really know what I feel like! Hopefully the suppression will keep building xx

OP posts:
ChocolateBoxCottage · 11/11/2025 13:42

I would just see how next hoe's following the guidelines. Then decide. I find eating anything to fatty makes me ill but that only lasts that night. So pork crackling. Didn't eat more than two squires- BIG mistake ( but so worth it). Chinese take away the same. What was horrible was going from 2.5 to 5mg. I think I lost 5lbs just from the side effects.

I haven't followed the guidelines to book myself but I do find the "1st" really hard so the second time was fine. If it's not rethink then

Iloveacuppatea · 24/11/2025 08:28

lost 12lb in that first month on 1.25 :)

is that 30 clicks a week? Or more frequently? Thanks x

OP posts:
Lemonysnickety · 24/11/2025 08:50

Can I ask those of you splitting doses where are you getting the extra pen needles. Thanks

Lemonysnickety · 24/11/2025 10:29

Thanks @FinancesSorted

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