On it for life then.........😐

[Ihavesomeballs]

I've lost 11kg on Mounjaro. I wasn't obese to start with but I'm tiny, 5ft 1 inch. I'm now just in the healthy weight BMI. I stopped my 5mg dose for 3 weeks as I had to wait till payday to order my next pen. In that time I wasn't eating any more than usual but I put on 2kg. So I guess I'm on it for life......which sucks as it's bloody expensive. Anyone else??

Mounjaro doesn't make ypu lost weight, it suppresses your appetite so it's easier to eat less.
If you've gained weight its because you're back to eating more calories. No ifs, no buts

No ifs, no buts……except for:

It works by changing how your body responds to food and energy:
a) Better Insulin Sensitivity
• Mounjaro helps your body respond more effectively to insulin, the hormone that moves sugar from your blood into your cells.
• When insulin works well, your body uses glucose for energy instead of storing it as fat.
• Poor insulin sensitivity often leads to fat storage, especially around the belly. Improving this reduces fat accumulation.
b) Reduces “Energy Overflow”
• Normally, when you eat more calories than you burn, your body stores the excess as fat.
• By activating GLP-1 and GIP receptors, Mounjaro signals your body to use energy more efficiently and avoid unnecessary fat storage.
• It also helps regulate blood sugar spikes after meals, which means fewer cravings and less overeating.
c) Encourages Fat Burning
• With improved insulin sensitivity and lower calorie intake (because you feel fuller), your body starts using stored fat for energy.
• Over time, this shifts your metabolism towards fat loss rather than fat storage.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5786199/

Meta analysis of a range of studies involving over feeding study participants. Studies showed considerable differences between participants in the amount of weight gained (some gaining little or no additional fat mass) despite the overfeeding being the same and most under laboratory conditions. The twin study cited here suggests a genetic component.

HTH

Obviously not read it all but it seems to be about the difference in overfeeding with carbs Vs fat Vs protein?

Where does it say some people some people can eat loads and not gain weight and some can eat very lean and gain weight? And when you say lean what exactly do you mean? Low calorie or eating lean meat or what?

If someone is already eating very little the wouldn't need WLI.

I say this as someone who had used them so I'm not jealous or anti WLI. Just bored of being the only one who can admit I eat too much.

I was obese due to eating too much. And now I get to buy myself a healthy BMI, yay!

I couldn't afford to stay on it long enough for that but I managed to maintain for 6 months now I'm starting again so fingers crossed 😄

Hope it goes well.

I think nearly everyone admits they eat too much, this doesn’t mean they eat crap, poor nutrition, are greedy, lazy, or ignorant of good nutrition knowlege, or don’t take any exercise, I think you’ve misunderstood what’s being said.

Sorry I've been on these threads for months so probably reacting to lots of people insisting they put on weight if they eat above 1000 calories a day etc. it's tiresome.

And yes I'm struggle to say in a calorie deficit but I eat 120g protein, 30g fibre, bulk my meals out with low calorie veg, rarely drink alcohol, strength train 4 times a week, walk or run on most of my lunch breaks etc. not lazy or ignorant, just a bit weak willed of an evening perhaps!

Same height as you and I’ve found I need to eat less than 800 cals & 3l water to lose weight. About 1000 to maintain.

The publication is a meta analysis (that is, researchers review a number of studies that meet specified inclusion criteria to see if they provide answers/evidence for a stated question or hypothesis). They are often, but not always, a preliminary stage to conducting primary research and the findings can inform study design etc.
So, while as you say, the researchers were particularly interested in the role of macronutrient composition in feeding. this was not necessarily the focus of the primary studies included.
From the report on one study: 'However, there was considerable variability in the response to overfeeding. It is notable that some individuals lost FM (fat mass) and reduced their body fat percentage despite eating an additional 1,000 kcal per day. Moreover, there was a significant genotype-overfeeding interaction for changes in body weight, FM, and FFM, suggesting that genetics do play a role in determining body composition changes in response to overfeeding.'
A study involving male monozygotic twins overfed by 1000 calories a day found within pair variation was not significant but that 'Considerable variation in response to overfeeding was again noted, but this variation was not distributed randomly among the 24 participants. Rather, significant genotype-overfeeding interactions showed that within-pair correlations were moderate to strong for changes in body weight (r=0.55), FM (r=0.50), subcutaneous fat (r=0.47), total visceral fat (r=0.72), and percent gain in visceral fat (r=0.90).' This suggests that fat gain in response to additional calories has a genetic component.
Another study, also overfeeding by 1000 calories a day, found that 'The average gain in body weight was 2.5 kg, of which 68% was FM. However, some participants gained as little as 0.25 kg while others gained 2.8 kg.'
The other cited studies also found considerable variation in weight gain and body composition as a response to overfeeding.

I have no idea what you mean by 'Where does it say some people some people can eat loads and not gain weight and some can eat very lean and gain weight? And when you say lean what exactly do you mean? Low calorie or eating lean meat or what?' I have not mentioned 'eating lean' - are you mistaking me for a different poster? What I am responding to is the idea that weight gain is as simple as calories in and calories out and that posters who have gained weight after stopping mounjaro despite continuing to eat in the same way, must be mistaken. @InfoSecInTheCity gave a brilliant explanation of how mounjaro normalises the physiological response to food intake above that explains this.

I think what I get tired of is the way some posts on these threads ignore scientific evidence, expert opinion and people's lived experiences to trot out simplistic tropes which they think will solve multi-faceted and complex issues. As H L Mencken said 'for every complex problem there is an answer that is clear, simple, and wrong.' (The Oxford comma is his).

@Fromthesidelines I am quite partial to an Oxford comma myself

I’m currently taking a maintenance dose of 3.75mg per fortnight, and I’m managing to maintain my weight. Ive been doing this since July. I’ve just started a new 7.5 pen which I hope will last me 20 weeks, after that I don’t know what I will do. I won’t qualify to buy it again as my BMI is no longer over 30 (although I am still classed as just overweight) In all honesty I would stay on it for life if it helped me to maintain my current weight!

Tastier than a Chelsea bun 😉

I’ve bought it when my BMI is less than 30, as I have been able to show I started above 30.

I agree with this partly. As in the more overweight/obese you are the more insulin resistant you become. I have the same issue. When I was diabetic they put me on metformin, I lost weight immediately and now I am pre-diabetic so no more medication for me. So yes the drugs work, but I did also watch my diet. I am not a person who snacks or eats between meals or eats much sweet but due to genetic disposition( being asian) I have a greater tendency to be diabetic. Have huge family history of it. But I am still battling exercise and trying to eat healthy as Doctors don’t think I should get medication and then eat whatever I like. So yes, medication makes it easier to eat what I like and still be skinny but since that isn’t an option I am eating as sensibly as possible and exercising. For example today I have done 30 mins of a full body dumbbell work out, 12,235 steps and eaten 3 meals in small portions. Also drank 2 litres of water and going to try to get to bed early so I get some rest as I have had a busy day at work. I work full time and also have two small kids. I still think if you lose weight with exercise you are likely to keep it off more than with just medication.

This was referring to my comment that some people can eat lean and put on weight. You have highlighted the phenomenon in one direction, which is to say that some people don't put on very much weight when eating a lot more calories while others put on a lot. It has also been observed that some people put on calories when they are eating the same food as lean people. So if they are not eating much, they still gain weight.

I have seen PP say this themselves that they put on weight while eating 1000 calories. This is a dangerously low calorie diet that doesn't supply sufficient nutrition for the average adult.

The research is heading in the direction that some people process carbohydrate and insulin in different ways to others. It doesn't matter how many calories they eat but how they process them. Measures to reduce obesity in the population should take account of this.

And it gives the lie to the predominant theory that calories in and energy out is the only way to lose weight.

Roughly half the people who use this type of medicine (GLP-1) to lose wetght will benefit from being on a maintenance dose for life - this is mainly due to half the population having insufficient receptors in their stomach to control satiety/hunger.Simply put, the food noise and hunger pangs are stronger in some people and simply trying to ignore them (aka will power) after stopping the medication will not work and will likely lead to weight gain. That said, 2kg weight gain isn’t a significant amount but I appreciate having lost weight any gain is disappointing.

Have you spoken with the company you buy it from about a suitable maintenance dose? If you’re now in a healthy range I would expect them to proactively encourage you to the lowest dose so as to not lose too much weight.

The good news is the patents will start to expire around 2030 which should dramatically reduce the price (in theory). Also, maintenance is usually the lowest dose, 2.5mg - which is also the cheapest on the market.

I don't personally know anybody on WLI who expects the jabs to do all the work. I've only heard anecdotes on mumsnet how some people just sit on their lazy arses stuffing their faces with pizza and weight is falling off. In real life, all people who have after years of numerous weight loss attempts decided to pay for the medication are tracking their macros and calories, eating healthy food and working out.

I know four people in real life on them, all are working hard along side it. And none of us ever sat on our arses stuffing our faces.

I think some people are just really jealous or resentful, they want the drugs and for whatever reason can’t access them, money whatever, so they come on line and have a go, as it’s anonymous. Some of them probably spew it in real life too.

I’ve never seen anything cause such bad feeling as fat people being able to lose weight, in a healthy and successful manner, and maintain it. It is annoying the fuck out of some folks.

Why did all these hormonal imbalances that make so many people obese not seen to be an issue decades ago?

(Again I'm taking WLI myself so not jealous/resentful)

I wouldn't be so sure they weren't. For as long as we've had photography there've been images of fat people. I've even seen one of a very large woman living in poverty in the East End about late 1800s, people were speculating about her probably being malnourished despite her size cos of the poor quality diet. It's quite conceivable some of them had hormonal imbalances.

Then factor in smoking, which was almost 50% of the adult population at peak in the 70s. Go a couple of generations before that and a good chunk of the population simply didnt have enough food. Any people who lived in those times and had hormone imbalances would also have presumably been influenced by those factors at a roughly representative level. They just didn't know or have an Internet to discuss it on.

There has always been fat people. It isn’t a new thing. It was just less post war, for obvious reasons, less food less money, and over the decades less energy was required to do things and more convenience available. If I look around my parents generation many of their peers were overweight, the beer or menopausal tummy. Being fat isn’t something new, just it is more common now as food is more accessible.

Of course there have always been fat people but nowhere near the numbers there are now.

Surely it's the type and ease of availability of food that's the problem?