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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

On it for life then.........😐

317 replies

Ihavesomeballs · 08/11/2025 15:39

I've lost 11kg on Mounjaro. I wasn't obese to start with but I'm tiny, 5ft 1 inch. I'm now just in the healthy weight BMI. I stopped my 5mg dose for 3 weeks as I had to wait till payday to order my next pen. In that time I wasn't eating any more than usual but I put on 2kg. So I guess I'm on it for life......which sucks as it's bloody expensive. Anyone else??

OP posts:
Iwanttoliveinagardencentre · 10/11/2025 10:29

I am two weeks away from stopping mounjaro.
I am at my goal weight after losing 9 and a half stones. Initial 3 stones on my own then the rest with the help of mounjaro.
I’m only stopping due to the price hike.
I had no side effects throughout my year on mounjaro even at the highest dose.
I felt really well on it, I believe it even helped my anxiety which has been a longterm problem.
I won’t titrate down because I really can’t afford to.
I will weigh myself weekly and continue with calorie counting. I fully expect some regain even if I eat the same calories because as I understand it one part of mounjaro’s mechanism works by effecting how calories convert to fat.
For many people who, like myself, have battled with their weight over decades and losing and regaining multiples stones a lifetime nhs prescription for mounjaro would be life changing and if I fail to see how this differs from the nhs paying for diabetes meds and others if caused by being seriously overweight.
How does it make economic or humanitarian sense to fund the consequences but not fund prevention?
I think the societal dislike of fat plays a huge part but morality of fat has no place in the nhs and if the “heal thyself” principle applies should patients with obesity related conditions then be refused treatment?

weericky · 10/11/2025 10:31

Gmary22 · 10/11/2025 10:11

You could just eat less.

Oh wow, thanks. I never thought of that. Will ditch the WLI right away. You have saved me so much money with your groundbreaking advice.

HansHolbein · 10/11/2025 10:37

Gmary22 · 10/11/2025 10:11

You could just eat less.

Canadian Lol GIF

.

Shitzngiggles · 10/11/2025 10:41

Gmary22 · 10/11/2025 10:11

You could just eat less.

Have you actually read any of the posts on here?

InfoSecInTheCity · 10/11/2025 10:55

Gmary22 · 10/11/2025 10:12

Insulin resistance is caused by being overweight. Food is th source of all the issues.

I developed PCOS during puberty, I became overweight during puberty because of hormone imbalances. I was eating the same as my family all of whom were healthy weight and exercising the same as I always had but all of a sudden I had out of control hormones that led to weight gain, yes that weight gain then made it worse and it became a vicious cycle of gain more weight, get more symptoms so gain more weight and one of the symptoms is that my body couldn’t lose weight. I lost weight during pregnancy when I got GD and the medical team finally medicated me for my hormone imbalance by giving me metformin and insulin, as soon as I had the baby, they stopped all treatment and told me it was up to me to control food and exercise. I maintained my diet and exercise as I had when pregnant and still gained weight.

Last year I got the T2 diagnosis and was again finally medicated and lo and behold, weight starts to fall off.

HeidiLite · 10/11/2025 11:02

Clearly we are overcomplicating things. Just eat less.
We could solve all mumsnet problems like that. Not enough money? Just earn more. Struggling with messy house? Clean better. Shall we go to alcohol addiction board and suggest that people can just drink less?

TheVoiceOfReason91 · 10/11/2025 11:35

HeidiLite · 10/11/2025 06:08

People who struggle with their weight so much that they are willing to pay considerable amounts have tried to lose weight many, many times before.

'Just eat less!' is not a revolutionary concept we were not introduced to previously. It's not that easy for everybody and clearly many people are not able to do it the better way. Maybe the reason is hormonal imbalances and some bodies working differently, or maybe some people are just lazy and have no willpower, like we hear day in and day out.

But even if the latter opinion is correct, and people are not able to lose weight the right way because they do not have the willpower, telling those people that without drugs is a superior option will not magically summon that willpower, will it?

No it won't but the sheer cost of the drugs is astronomical and could be spent on making better food choices trust me I struggle with my weight and have done since being a child I'm a classic example of a yo-yo Dieter I lost over 4 stone in 6 months following my own advice my problem is I struggle with the knowledge on how to maintain and adjust my macros to maintain so I end up regaining the weight
I have just started my diet again as I had an operation on my back in October that I've been waiting for since march so with in that time I've gained weight again
But I absolutely flat out refuse to say that the drugs are the best option granted they are probably the easiest and that's why majority of people use them and I have nothing against people using them but if the same people actually looked at there tdee (total daily energy expenditure) and then said right I will intake 500 calories less then that per day you would lose about 1lb a week as there are around 3500 calories per lb of weight
And to answer about hormones n stuff that's why I say learn how your body responds to different foods you don't have to go hard at it from day 1 if you struggle it would actually be best to do fortnightly goals and the first goal would be to maintain your current weight for 2 weeks and keep a food and drink log then your next 2 weeks could eat 150 calories less for your breakfast so on so you slowly adapt your body to the changes also drink enough water so your body doesn't hold onto ie as I say try get clear pee with in 2hrs of getting out of bed and keep it that way until you go to bed again

PumpkinTwistyWindToots · 10/11/2025 11:51

Shitzngiggles · 10/11/2025 10:41

Have you actually read any of the posts on here?

Of course they haven't - too excited about sticking the boot in as quickly as possible

Frenchfrychic · 10/11/2025 11:59

TheVoiceOfReason91 · 10/11/2025 11:35

No it won't but the sheer cost of the drugs is astronomical and could be spent on making better food choices trust me I struggle with my weight and have done since being a child I'm a classic example of a yo-yo Dieter I lost over 4 stone in 6 months following my own advice my problem is I struggle with the knowledge on how to maintain and adjust my macros to maintain so I end up regaining the weight
I have just started my diet again as I had an operation on my back in October that I've been waiting for since march so with in that time I've gained weight again
But I absolutely flat out refuse to say that the drugs are the best option granted they are probably the easiest and that's why majority of people use them and I have nothing against people using them but if the same people actually looked at there tdee (total daily energy expenditure) and then said right I will intake 500 calories less then that per day you would lose about 1lb a week as there are around 3500 calories per lb of weight
And to answer about hormones n stuff that's why I say learn how your body responds to different foods you don't have to go hard at it from day 1 if you struggle it would actually be best to do fortnightly goals and the first goal would be to maintain your current weight for 2 weeks and keep a food and drink log then your next 2 weeks could eat 150 calories less for your breakfast so on so you slowly adapt your body to the changes also drink enough water so your body doesn't hold onto ie as I say try get clear pee with in 2hrs of getting out of bed and keep it that way until you go to bed again

Try to understand that not everyone is in the same financial bracket as you. I can do both, make better food choices and buy the drugs. They are affordable to me. And quite frankly your assumption that I or anyone else is overweight due to bad food choices is offensive and shows your complete lack of understanding of the subject at hand.

Please educate yourself. Do better.

NikkiPotnick · 10/11/2025 12:08

I see the thread is now attracting financial as well as scientific expertise!

Frenchfrychic · 10/11/2025 12:11

Do you think we should ask for a sticky on this sub forum. Something like

before posting, please note that people are not fat simply as they don’t understand nutrition, are greedy, lazy, and don’t understand about calories in versus out, tdee,or bmr. Please refrain from telling people to eat less and move more.

please also note, most fat people have tried every diet possible, for many many years and have been unable to succeed and maintain weight loss. They do not pick injections as the easy option. They pick them as the last option.

lastly, as you cannot access the medication yourself, be it due to cost, current weight etc, please try to remain respectful and keep your jealousy and resentment away from the board.

HeidiLite · 10/11/2025 12:11

No it won't but the sheer cost of the drugs is astronomical and could be spent on making better food choices

How? I am not struggling with my weight because I can't afford more expensive food.

NikkiPotnick · 10/11/2025 12:19

I actually do feel a great deal of sympathy for those who need the drug and can't access it. Very much hope they won't have too much longer to wait for NHS access, both from a compassionate and taxpayer perspective.

But bullshitting is not going to help them.

HeidiLite · 10/11/2025 12:29

@Frenchfrychic we should also add that just because someone is overweight, it does not mean they have no idea about fitness and exercise, and should just take a short walk, or maybe do some biceps curls with tins of beans. (I've done a full marathon training without losing weight, pretty sure adding a walk around the block would not have made a difference there.)

Frenchfrychic · 10/11/2025 12:33

@HeidiLite , absolutely, good point, we understand exercise too, most fat people are very well educated on what is required across a broad spectrum, lack of knowledge is not the issue, and fhat can be evidenced by hundreds of threads on social media where people are fully able to eat healthily, to the required portion size and work out when on the medication.

Frenchfrychic · 10/11/2025 12:36

NikkiPotnick · 10/11/2025 12:19

I actually do feel a great deal of sympathy for those who need the drug and can't access it. Very much hope they won't have too much longer to wait for NHS access, both from a compassionate and taxpayer perspective.

But bullshitting is not going to help them.

I agree, I have full sympathy for anyone who wants the drugs and can’t access them, for whatever reason. I have no sympathy for those who due to that, come on line and start providing mis information, scare mongering, or accusing people of being lazy, ill educated, greedy or ignorant.

im stunned someone wrote up thread the cost is astronomical so we should be using that money to make better food choices, not least as it is utterly illogical, if we can afford the meds and long term, we can afford good food.

chaosmaker · 10/11/2025 12:40

Themaghag · 09/11/2025 22:06

Would you be prepared to spend the rest of your life on Keto and fasting? It sounds totally grim.

Probably have to if I wat to come off all my meds. It has the bonus of lessening hunger and boosting energy. I'm a MJ canddate but turned it down.twice
Personally the 800 cal blood sugar diet did wonders and that was only low carb but I was exercising on top (bodyweight only, no gym or other expense)
Can eat a lot on 800 cala if you tailor it right.
I thought I'd fixed myself but hadn't so I need to go back on it.

NoTouch · 10/11/2025 12:47

TheVoiceOfReason91 · 10/11/2025 11:35

No it won't but the sheer cost of the drugs is astronomical and could be spent on making better food choices trust me I struggle with my weight and have done since being a child I'm a classic example of a yo-yo Dieter I lost over 4 stone in 6 months following my own advice my problem is I struggle with the knowledge on how to maintain and adjust my macros to maintain so I end up regaining the weight
I have just started my diet again as I had an operation on my back in October that I've been waiting for since march so with in that time I've gained weight again
But I absolutely flat out refuse to say that the drugs are the best option granted they are probably the easiest and that's why majority of people use them and I have nothing against people using them but if the same people actually looked at there tdee (total daily energy expenditure) and then said right I will intake 500 calories less then that per day you would lose about 1lb a week as there are around 3500 calories per lb of weight
And to answer about hormones n stuff that's why I say learn how your body responds to different foods you don't have to go hard at it from day 1 if you struggle it would actually be best to do fortnightly goals and the first goal would be to maintain your current weight for 2 weeks and keep a food and drink log then your next 2 weeks could eat 150 calories less for your breakfast so on so you slowly adapt your body to the changes also drink enough water so your body doesn't hold onto ie as I say try get clear pee with in 2hrs of getting out of bed and keep it that way until you go to bed again

You might want to consider a MN name change pet 🤔

trust me I struggle with my weight - each persons struggle is individual, I trust you struggle with your weight, it seems you cannot trust I also struggle with mine to extent medical intervention is required...

I have just started my diet again - been there, done that, for over 30 years

if the same people actually looked at there tdee - Of course we all know about TDEE, give us some bloody credit!

I say learn how your body responds to different foods - 30 years of mini goals, experiments and journals later, that’s exactly the problem, my body doesn’t respond the same way yours might

keep a food and drink log - you should copyright that groundbreaking advice!

also drink enough water - fuck me, honestly, revolutionary stuff!

You seem to be confusing obese with stupid.

TheSlimmingPumpkin · 10/11/2025 12:55

Gmary22 · 10/11/2025 10:11

You could just eat less.

Loving it 😂. Never thought of that one. But that’s already ticked off on my bingo card

Ihavesomeballs · 10/11/2025 13:31

I definitely think we need to have a discussion around what is causing insulin resistance in the first place. I have been a keto person on and off for over 20 years, I knew I had to control my carbs when I put on 4 stone with my first child. It worked for a long time but it's bloody miserable and expensive just eating meat/ fish and vegetables and salad. I love this medication and the way it means we can eat 'normally', as per the current healthy eating guidelines........😐

OP posts:
FlowerUser · 10/11/2025 14:27

@PumpkinTwistyWindToots and anyone else who asked about my sources, you will see that I posted them a few minutes after my original post.

I try very hard not to make claims I can't substantiate and I should have posted the links in the original post.

I also included a study saying that tapering down WL jabs before stopping can reduce weight gain for six months.

I further said that the science is new and more research is being done and that the cost will reduce in the next 10-15 years (depending on how long since the original patents were filed) as generics are allowed onto the market.

I believe that anyone embarking on WL jabs usage should know this before they start so they are fully informed, particularly because it is currently so expensive.

I am not against WL jabs at all. I think they are enormously helpful for many people, particularly those who have lifelong obesity and have huge amounts of weight that are impossible to shift without surgical or medical intervention - this includes members of my family. I also think WL jabs are achieving amazing things in many more conditions other than obesity. I think some people could be on them for life for the reasons I have given, backed up by reputable scientific research.

And to those who say "eat less" or "eat less calorific food", you have bought into the myth that "food in, energy out" is why some people gain weight. It is a mainstream view and will take years to reverse, but it is not true. Some people can eat as much as they like of calorie-rich food and still not gain weight. Some people can eat as leanly as lean people and put on loads of weight.

In the end, it comes down to which foods are consumed (and saying calorific or UPFs doesn't cover the whole story) and this post by Gary Taubes goes into some depth about this:

https://open.substack.com/pub/uncertaintyprinciples/p/calorie-restriction-vs-carb-restriction

And this earlier post about WL jabs is informative about what might be happening with the injections that also explains why some people get fat and others don't.

https://open.substack.com/pub/uncertaintyprinciples/p/why-do-we-lose-weight-on-glp-1-drugs

PumpkinTwistyWindToots · 10/11/2025 15:03

FlowerUser · 10/11/2025 14:27

@PumpkinTwistyWindToots and anyone else who asked about my sources, you will see that I posted them a few minutes after my original post.

I try very hard not to make claims I can't substantiate and I should have posted the links in the original post.

I also included a study saying that tapering down WL jabs before stopping can reduce weight gain for six months.

I further said that the science is new and more research is being done and that the cost will reduce in the next 10-15 years (depending on how long since the original patents were filed) as generics are allowed onto the market.

I believe that anyone embarking on WL jabs usage should know this before they start so they are fully informed, particularly because it is currently so expensive.

I am not against WL jabs at all. I think they are enormously helpful for many people, particularly those who have lifelong obesity and have huge amounts of weight that are impossible to shift without surgical or medical intervention - this includes members of my family. I also think WL jabs are achieving amazing things in many more conditions other than obesity. I think some people could be on them for life for the reasons I have given, backed up by reputable scientific research.

And to those who say "eat less" or "eat less calorific food", you have bought into the myth that "food in, energy out" is why some people gain weight. It is a mainstream view and will take years to reverse, but it is not true. Some people can eat as much as they like of calorie-rich food and still not gain weight. Some people can eat as leanly as lean people and put on loads of weight.

In the end, it comes down to which foods are consumed (and saying calorific or UPFs doesn't cover the whole story) and this post by Gary Taubes goes into some depth about this:

https://open.substack.com/pub/uncertaintyprinciples/p/calorie-restriction-vs-carb-restriction

And this earlier post about WL jabs is informative about what might be happening with the injections that also explains why some people get fat and others don't.

https://open.substack.com/pub/uncertaintyprinciples/p/why-do-we-lose-weight-on-glp-1-drugs

Edited

Thanks
given that WLI have only been widely available for the public since 2022, there is no way that a comparison can actually be made with traditional weight loss methods and regain.
it makes sense that some people would initially regain quickly after coming off a WLI. There is a definite bounce back in appetite when the drug leaves your system and I also completely acknowledge that relying on the drug rather than solely on willpower is easier - so when the drug is gone, willpower is less of a habit. That doesn't follow that weight gain follows the same trajectory for 5 years - there's no way to know that.

Frenchfrychic · 10/11/2025 15:07

PumpkinTwistyWindToots · 10/11/2025 15:03

Thanks
given that WLI have only been widely available for the public since 2022, there is no way that a comparison can actually be made with traditional weight loss methods and regain.
it makes sense that some people would initially regain quickly after coming off a WLI. There is a definite bounce back in appetite when the drug leaves your system and I also completely acknowledge that relying on the drug rather than solely on willpower is easier - so when the drug is gone, willpower is less of a habit. That doesn't follow that weight gain follows the same trajectory for 5 years - there's no way to know that.

Yes but there was 6000 or 7000 people in the trials. So some data can be extracted.

Frenchfrychic · 10/11/2025 15:07

PumpkinTwistyWindToots · 10/11/2025 15:03

Thanks
given that WLI have only been widely available for the public since 2022, there is no way that a comparison can actually be made with traditional weight loss methods and regain.
it makes sense that some people would initially regain quickly after coming off a WLI. There is a definite bounce back in appetite when the drug leaves your system and I also completely acknowledge that relying on the drug rather than solely on willpower is easier - so when the drug is gone, willpower is less of a habit. That doesn't follow that weight gain follows the same trajectory for 5 years - there's no way to know that.

Plus why wouldn’t it be the same, the drug doesn’t change your biology, and no drug works when you dint take it.

RunSlowTalkFast · 10/11/2025 15:19

@FlowerUser
"Some people can eat as much as they like of calorie-rich food and still not gain weight. Some people can eat as leanly as lean people and put on loads of weight."

You can't genuinely believe this?

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