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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Starting 5mg and nervous

25 replies

Elliebird2 · 30/09/2025 11:21

After 8 weeks on 2.5mg I’m moving to 5mg this week but feeling extremely nervous after all the horror stories I’ve read online and lots of people saying to go to 3.75mg. I do feel it’s time to move up.

Are there any positive experiences of going from 2.5 to 5 and would it be worth me trying 5mg first and then if it’s too much dropping to 3.75mg or starting 3.75mg? Thanks

OP posts:
TheGreatWesternShrew · 30/09/2025 11:23

Don’t be nervous! I went straight to 5mg within the first week and it’s been amazing. Slightly nauseous and no appetite for day 1 and 2 and then just decreased appetite and food noise. After 2 weeks no negative side effects at all. It’s been great

Step2253 · 30/09/2025 11:46

I did 10 weeks on 2.5mg and went straight to 5mg. I am now on week 4 and no issues at all.

Kipperandarthur · 30/09/2025 12:43

I went straight to 5mg after the first 4 weeks on 2.5 and it was absolutely fine.
4 months later I'm still on 5mg and will move up to 7.5mg next month.

morbidcuriosity · 30/09/2025 12:48

I did 5 weeks at 2.5 then straight to 5. Was absolutely fine.. few weeks in on 5 is when I first got constipated but I wasn't eating enough fibre ..

Go for it, just remember to drink and add some fibre foods.. kewi, prunes, bran flakes your be grand..

MisfitMagpie · 30/09/2025 13:00

I did 10 weeks (2 pens) on 2.5mg then moved up to 5mg, I had no issues with the increase.

LaGioiosanotLeviosa · 30/09/2025 13:46

I did 4 weeks on 2.5 then straight to 5. It was totally fine!

idrinkandiknowthings · 30/09/2025 13:53

It varies for everyone. I went from 2.5 to 5 and had horrendous sickness and trots. I dropped down to 2.5 then increased gradually and I'm now fine. I'm still on 5.

I know someone who absolutely rocketed through increased doses and didn't have a single side-effect. Good luck!!

TheRealGoose · 30/09/2025 17:21

Op if it was that bad no one would,stay on 5mg or move up past it.

DBatteryBand · 30/09/2025 17:46

I went from 2.5mg to 5mg after a longish time. I had a few moments of sitting looking sorrowfully at my breakfast, wondering how on earth I was going to eat it, but that passed rapidly and was my only real issue. I have been on 5mg for months now. Moving up to 7 5mg this weekend and feeling chipper about it.

HappyWineDay · 30/09/2025 23:42

I’d personally say get the 5mg pen and try 3.75mg. Going from 2.5mg to 5mg is doubling the dose, that’s a big step. Nowhere else in the pen sizes do you get that same proportion increase.

Scandalicious · 01/10/2025 05:23

It varies so much, so,it depends how much you can adapt your schedule if you do react badly, I was advised to go up to 3.75 first and I am so glad I didn’t go to 5mg because 3.75 made me really unwell and now on 3.25 I am still unwell. I just cannot imagine how bad 5 would have been. I had been on 2.5 mg for months and it really wasn’t doing much, but gosh, even a small increase makes a big difference to some users like me.

Seahorsesplendour · 01/10/2025 05:40

I was also nervous and hoping to stay on lower doses so did 3.75mg but very little difference for me to the 2.5mg dose so topped it up to 5mg on day 3 then did 5mg 4 days later and all fine.

MumofSpud · 01/10/2025 05:44

I went on 5mg after 8 weeks of 2.5 and was v nervous as well
After the first 2 doses I was more nauseous than the 2.5 but that has gone now
I am having to be careful of constipation but the food suppression / lack of noise is great!
I am not going onto 7.5 - no need!

Macaroni46 · 01/10/2025 08:09

I was so ill after my first 5mg dose that I couldn’t go to work or get out of bed. Vomiting, shaking, flu-like symptoms, headache. Lasted 5 days.
After that awful episode I waited 10 days and then did 3.75 for a month before moving up to 5 which is where I’ve stayed for now.

Elliebird2 · 02/10/2025 09:55

I just did the 5mg anyway, fingers crossed I’ll be ok on it. Heart was pounding, I’m so sad lmao

OP posts:
ThirdDesk · 02/10/2025 10:22

24 hours afterwards I got the sulphur burps, then emptied my entire intestines into the toilet for the next 48 hours, while subsisting on 800 cals. Then - nothing. I've been on it ever since and had nothing like that. I have Pepso Bismol and peppermint oil capsules which I should have had in the house beforehand, and I used the oil until it ran out but haven't replaced it. The PB is untouched. I have no plans to change from 5mg.

Kazzaa46 · 02/10/2025 10:52

Elliebird2 · 02/10/2025 09:55

I just did the 5mg anyway, fingers crossed I’ll be ok on it. Heart was pounding, I’m so sad lmao

Let me know how you get on. I’ve ordered 5mg for month 2 as 2.5mg is no longer working and I’m only in week 3. I’m equally anxious as you but had no real side effects on 2.5 so fingers crossed.

Hopefully you’ll report back all good with a bit of luck ☺️

Elliebird2 · 02/10/2025 11:02

Kazzaa46 · 02/10/2025 10:52

Let me know how you get on. I’ve ordered 5mg for month 2 as 2.5mg is no longer working and I’m only in week 3. I’m equally anxious as you but had no real side effects on 2.5 so fingers crossed.

Hopefully you’ll report back all good with a bit of luck ☺️

I will do!

OP posts:
Elliebird2 · 02/10/2025 11:04

ThirdDesk · 02/10/2025 10:22

24 hours afterwards I got the sulphur burps, then emptied my entire intestines into the toilet for the next 48 hours, while subsisting on 800 cals. Then - nothing. I've been on it ever since and had nothing like that. I have Pepso Bismol and peppermint oil capsules which I should have had in the house beforehand, and I used the oil until it ran out but haven't replaced it. The PB is untouched. I have no plans to change from 5mg.

I’ve got some pepto bismal just in case! Glad it was ok for you after the initial first two days of it

OP posts:
Mangolover123 · 02/10/2025 11:26

Absolutely no issue here. Did 4 weeks on 2.5 then have done 22 weeks so far on 5mg. I have only lost about 2 stone on it, but I did lose 2 stone prior to going on it. I can eat fairly normally so still have to be careful. Weight lose is modest but my intention is to go slow and steady plus I have had a big birthday a multiply holidays so that has hampered progress but I am living my life.
I love it and if I could be on it for life I would.
I have about 7 weeks left of 5 and I have a 7.5 in the fridge. But I am reluctant to move up. Loss has slowed right down but part of this is I need to manage my food in take. I take collagen and do weights most days. I have another stone to lose. Then I will be a 12/14, which I would be very happy with.
I feel fabulous!

Scandalicious · 03/10/2025 08:55

Hope you are well today, Ievels peak about 24 hours after dose I think so if you can get through ok today you might be in the clear!

Elliebird2 · 03/10/2025 12:40

I felt a little bit nauseous when I woke up this morning and I have an injection site rash (I get these every month though) but otherwise absolutely fine so far!!

OP posts:
Elliebird2 · 05/10/2025 15:43

Kazzaa46 · 02/10/2025 10:52

Let me know how you get on. I’ve ordered 5mg for month 2 as 2.5mg is no longer working and I’m only in week 3. I’m equally anxious as you but had no real side effects on 2.5 so fingers crossed.

Hopefully you’ll report back all good with a bit of luck ☺️

Heya, just thought I’d update you. 3 days since I took 5mg and it’s been a non event overall, suppression is good. No sickness. It’s been alright! Also realised I def needed to move up so glad I took whole dose and not 3.75mg. I know everyone is different though :)

OP posts:
Kazzaa46 · 05/10/2025 15:48

@Elliebird2 that’s good news about no side effects and good suppression. Last 2.5mg for me tonight so I’ll be starting my 5mg next weekend and hope I get the suppression back

Scandalicious · 05/10/2025 17:34

Good news OP!

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