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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

June 2025 Starters - Mounjaro (thread 4)

1000 replies

FoxRedPuppy · 10/07/2025 18:27

Into our second month now!

OP posts:
Thread gallery
14
FoxRedPuppy · 06/08/2025 12:34

farfallarocks · 06/08/2025 11:56

interesting what is a set point weight!
I’ve also lost very quickly, 11kg in 6 weeks (!)

At point weight is why 95% of all diets fail. It’s the weight your body works to be at comfortably. The problem is as we gain weight (or yo yo diet) our set weight often increases. So every time you stop dieting your body tries to get back to a certain weight. Hence regaining the weight.

It’s also why it so hard just to stay eating healthy after a while. Your body changes the metabolism and hunger cues in order to get you to eat more, to get to your set point weight.

It is possible to lower the set point but only very slowly.

There is a really good book called “Why diets don’t work” By Sandra Aamoht. She also did a great Ted talk on it.

OP posts:
RockChik · 06/08/2025 13:05

SnackcidentProne · 05/08/2025 21:37

Haven’t checked in for a while. Tomorrow will be the start of week 7 and have lost 9.5kg. I’ve been on 5mg this week but the suppression is really high so might reduce it tomorrow.
Is it best to do less clicks or use the needles I have for the golden dose?

@SnackcidentProne You need to extract the golden dose with a disposable insulin syringe. I did it for the first time this morning and it was really easy.

SnackcidentProne · 06/08/2025 13:15

RockChik · 06/08/2025 13:05

@SnackcidentProne You need to extract the golden dose with a disposable insulin syringe. I did it for the first time this morning and it was really easy.

Thanks. I used the golden dose on my last 2.5mg. I’ve gone up to 5mg but I think it’s too high for me.

finalpunt · 06/08/2025 13:16

@SnackcidentProne I do 45 clicks on my 5mg pen to get 3.75mg dose. I did go up to 5mg but suppression and SE were to much so dropped down the dose.

SnackcidentProne · 06/08/2025 13:19

@finalpuntthanks I’m going to try this today. Strange I had no constipation on 5mg which I had on 2.5mg but suppression was so high I was struggling to eat.

RockChik · 06/08/2025 13:23

SnackcidentProne · 06/08/2025 13:15

Thanks. I used the golden dose on my last 2.5mg. I’ve gone up to 5mg but I think it’s too high for me.

@SnackcidentProne I got my first 5mg pen yesterday, but I’m going to start on 3.75mg and see how I get on. Why don’t you dose down with your next jab?!

finalpunt · 06/08/2025 13:25

SnackcidentProne · 06/08/2025 13:19

@finalpuntthanks I’m going to try this today. Strange I had no constipation on 5mg which I had on 2.5mg but suppression was so high I was struggling to eat.

I had the opposite problem, couldn't get off the toilet for 2 days. Feel loads better on 3.75, suppression was still really strong on day 2 ( couldn't get more than a couple of protein yoghurts down) by day 3 suppression good but able to eat my 3 meals again.

flameprincess · 06/08/2025 13:25

It's true that there is a theory that our body has a “set point” weight range it tries to maintain. If you go below it, hormonal changes (like increased ghrelin and decreased leptin) push you to eat more and regain weight.

I do find it mind boggling how much, despite a healthy weight being good for us biologically, our brains and bodies seem to do everything they can to keep us overweight despite our efforts.

The whole song and dance of too many calories = weight gain versus too little calories = also weight gain cuz your body thinks it needs to hold on to fat, etc etc.

Also was listening to the Fat Science podcast (highly recommended) and the doctor on that discusses how even you simply feeling guilty for eating a certain food, or not liking your weight on the scale can trick your brain into thinking food is scarce, results in you guessed it, further metabolism slow down. It seems that when we try to lose weight, especially in ways that feel restrictive or stressful, our bodies often interpret that as a threat, triggering biological responses that make weight loss harder.

It really is a minefield of obstacles to navigate through to lose weight isn't it.

SewerOrLess · 06/08/2025 13:39

I have, finally, after almost 3 weeks of being 2 lbs away and gaining and losing the same lb - got to exactly 2 stone under where I started on June 1st. I have symbolically got 4 bin bags of clothes to go to charity as well.

SomethingAboutYou · 06/08/2025 13:42

@flameprincess that's so interesting. So much of the human body still relies on really primitive responses, we feel really far away from caveman days but the reality is, our bodies are designed to keep us alive, and if that means food is scarce, it takes steps to keep us from starvation (even if it's just a diet or attempt to lose weight). Same as when you have a baby, the mother's body kicks in so many different reactionary habits without us realising, but they're all geared towards keeping the baby safe and well!

Catladyof7 · 06/08/2025 15:23

Quick question for those taking smaller doses .

If you use a higher dose pen and take lower doses, making the pen last say 6-8 weeks for instance and its kept in the fridge all the time, is this ok ?

Has anyone noticed a lower suppression or anything different doing it that way as it says only use for 30 days ?
Wondering as thinking of getting the higher dose pen and taking lower doses.
Thanks

FoxRedPuppy · 06/08/2025 15:58

Catladyof7 · 06/08/2025 15:23

Quick question for those taking smaller doses .

If you use a higher dose pen and take lower doses, making the pen last say 6-8 weeks for instance and its kept in the fridge all the time, is this ok ?

Has anyone noticed a lower suppression or anything different doing it that way as it says only use for 30 days ?
Wondering as thinking of getting the higher dose pen and taking lower doses.
Thanks

There is no way of knowing if it’s ok as it being used against the advice of the medication. I used lower doses in my most recent pen, but will just chuck it.

Personally, I wouldn’t mess around with my other medication, so I’m not sure about doing it with this.

Lots of people probably do and don’t have any issues, but that in itself isn’t evidence that it is safe. I think the biggest risk is the introduction of bacteria. Which still happens with fridge, but obviously there is lower risk.

OP posts:
FoxRedPuppy · 06/08/2025 16:04

From what I’ve read the issue is that MJ contains a preservative which degrades over 30days. So a day over isn’t likely to make a difference. But I wouldn’t go as far as 14 days over. Similar to eye drops which contain preservatives. They have to be chucked after 30 days. It’s a pain as mine are expensive. But I don’t want a nasty eye infection.

OP posts:
RockChik · 06/08/2025 16:25

Catladyof7 · 06/08/2025 15:23

Quick question for those taking smaller doses .

If you use a higher dose pen and take lower doses, making the pen last say 6-8 weeks for instance and its kept in the fridge all the time, is this ok ?

Has anyone noticed a lower suppression or anything different doing it that way as it says only use for 30 days ?
Wondering as thinking of getting the higher dose pen and taking lower doses.
Thanks

@Catladyof7 I just received my first 5mg pen and plan on starting on 3.75mg. If that suits me I’ll stay on that dose and use the pen until it’s finished, despite being past the advised use by date. I’ve heard of many people using the same pen for two months without issue, although I do realise that isn’t evidence for it being safe. I guess I’m prepared to take the risk, as I feel it’s a small one. Only you can decide whether to or not.

RussianDoll76 · 06/08/2025 18:08

Catladyof7 · 06/08/2025 15:23

Quick question for those taking smaller doses .

If you use a higher dose pen and take lower doses, making the pen last say 6-8 weeks for instance and its kept in the fridge all the time, is this ok ?

Has anyone noticed a lower suppression or anything different doing it that way as it says only use for 30 days ?
Wondering as thinking of getting the higher dose pen and taking lower doses.
Thanks

Hey, my sister uses mj totally off book. She has a 2.5mg and she has used it 2/3 and 4 weeks between doses . She still has suppression so only uses as and when she feels it’s wearing off, she’s still losing well but her pen is always over the 30 days and she has been fine. The pharmacy told me personally that it was ok to use a pen that was actually past its shelf life. ( It had been in my fridge for months as I wasn’t scared to start it. She said they have so little data on mounjaro that current guidelines all very precautionary at this stage and they’ve been advised that criteria will change soon.

RussianDoll76 · 06/08/2025 18:08

My friend is also maintaining using a 15mg pen and he is micro dosing every few weeks nonissues for him either 😁.

MissMogs · 06/08/2025 18:31

I have my 7.5 pen ready, but was planning to extract what’s left of the 5 to do an in between dose. There should be enough liquid as I only did 45 clicks for the first 2 jabs of the month. But I’m so worried about trying to extract it and use a long needle to jab it that I’m seriously thinking about just going straight to 7.5!

BadgerFace · 06/08/2025 19:18

MissMogs · 06/08/2025 18:31

I have my 7.5 pen ready, but was planning to extract what’s left of the 5 to do an in between dose. There should be enough liquid as I only did 45 clicks for the first 2 jabs of the month. But I’m so worried about trying to extract it and use a long needle to jab it that I’m seriously thinking about just going straight to 7.5!

I was nervous about extracting the golden dose the first time but it was absolutely fine! The needles on the insulin syringes are longer but really that’s in comparison to the needles with the pens which are TINY so they are not really very big if you choose a different comparator.

Give it a go, you can always change your mind before jabbing. But you can do it!

MissMogs · 06/08/2025 19:40

BadgerFace · 06/08/2025 19:18

I was nervous about extracting the golden dose the first time but it was absolutely fine! The needles on the insulin syringes are longer but really that’s in comparison to the needles with the pens which are TINY so they are not really very big if you choose a different comparator.

Give it a go, you can always change your mind before jabbing. But you can do it!

Thank you for the encouragement!!

HappyWineDay · 06/08/2025 19:58

The pens have a shelf life of years when unopened so I’m not buying it about the preservative losing its efficacy. It’s benzyl alcohol and a bit of phenol. They don’t disappear.
The issue is whether using the pen introduces bacterial infection. I would personally consider the following:

Am I meticulous in wiping the rubber seal before attaching the needle?
Do I always use a sterile needle?
Do I ensure I don’t inject air into the pen, especially when using an insulin syringe?
All techniques to ensure no bacteria get in there.

Then I think about what helps bacteria grow and that’s temperature. The manufacturer says you can keep the pen outside the fridge once opened, at temperatures up to 30C. So I think about whether that means it would keep longer than 30 days if kept in a fridge? I think about what happens with fresh food kept in the fridge or in a warm room, and which last longer due to bacteria.

Then I would consider the manufacturer’s recommendations regarding spotting contamination - cloudiness, particles, in the liquid.

These are all the things I’d personally think about if I was considering going over 30 days. This isn’t advice for anyone else whatsoever. Just my own thoughts for my own use.

Chellooo · 06/08/2025 20:08

Anyone else having a bloody nightmare with Medexpress? Pens been sitting on awaiting dispatch status for 3 days and when I'm questioning them they can't give me an answer! The confirmation email said it would have been dispatched within 1 business day.
When I asked to cancel the order they say they can only request it from the refund team and to check back.with them in another day... I'm honestly pulling my hair out with them

magnoliaday · 06/08/2025 21:43

Feeling a bit meh today soo tired good job im off this week stomach curning a bit feels like it’s so full of water but not managed too much. I know it’s not necessarily a mj thing could be I’ve stopped and rested thing

Puffalicious · 06/08/2025 23:42

Hey all,

Reading with interest. Not been on in a while - on holiday twice & a busy Summer with youngest off school.

I've had 8 doses & I'm 17lbs down. Have had a bit of yo-yo & frustration at plateauing for a few weeks, but dropped again this week.

I had no SE on 2.5mg, but on 3.75mg I've had less suppression (strangely) but awful, terrible sulphur burping & wind down below. It really is constant. Any tips from anyone who's had the same?

I'm going back to work this time next week after 7 weeks off (Scottish teacher) & really anxious about all this burping & wind in the classroom when I can't escape constantly!

TIA

Puffalicious · 06/08/2025 23:43

I

DownhillAllTheWay · 07/08/2025 06:05

Went away on holiday and forgot my pen, so had ten days between doses. Didn’t lose any weight on holiday which is a bit disappointing as I really kept my intake very low - still had full appetite suppression even with the longer gap. Had one scampi and chips takeaway all week and the rest of the time was my usual protein/salad/veg/minimal carbs.

trying to convince myself that’s ok, I didn’t gain. But a bit worried for what maintenance will look like in the future if my minimeals aren’t sufficient for weight loss.

ordered my next pen and decided to stay with 5mg as I feel no hunger at all and have up until holiday been losing steadily. Now thinking maybe I should have gone up to 7.5 after all but I think the side effects on 5 are more than enough for me right now.

I should be pleased I didn’t gain. But my head is telling me I should just have given in and eaten the ice creams and churros and all the other bits I resisted if not giving into them didn’t magically make me thin. I know it doesn’t work like that. But…

weirdly, I wasn’t constipated at all the whole week, despite having forgotten my senna. Hope back home and everything stops back up again. Extra annoying!

SW 92kg
CW 81.9kg
TW daring to move it down to 60kg after starting to aim for 65.

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