Feeling awful on 5mg

[FifiFiadh]

I’ve had 4 weeks of the 2.5 mounjaro and took my first 5mg on Monday. I felt a bit nauseous but ok, but on Tuesday I was utterly wiped out. Banging headache, throwing up, discomfort in my stomach. I spent 2 days in bed and have just got up today but still feeling a bit shaky.
Whats the best advice?

I would increase in increments. I went from 2.5 to 3.75 and had a day of horrific D&V. The next week I went to 3, then 3.25 then 3.75 then 4 and been ok.

@CaramelEmporium Thanks for that advice.

Advice depends on why you moved up really?

Because that’s what my supplier suggested.

If that’s the only reason I would go back down to 2.5mg, no need to move through the doses if it’s working fine.

I had minimal side effects on 2.5mg but 24 hours after the first 5mg I was burping for Britain, and then had awful diarrhea for two days. Since then - nothing. Next jab - nothing. It seems like a blip. I'm in no rush to move on from 5mg.

I was seriously reconsidering everything on day two of 400 cals and constant agonising toilet trips - then as soon as it started it went away again. I really hope it's the same for you.

I went from 2.5mg to 3.75mg and then just stayed there for nearly a year!

You might find now you have done the biggest part of the 5mg step up the worst of side effects will quickly be behind you once your body gets used to it, or you might find they continue next week as the 2nd 5mg dose will increase the concentration to a new higher level in your body again.

If you want to be cautious perhaps try mid way at 3.75mg for 2-3 weeks and see how it suits you. Or if you want to aim for 5mg, power through and see if things settle.

I personally would not to change doses up/down every week as it takes time (4 weeks on increase, possible similar on decrease) before reaching a steady level and it could make it hard to know what level is causing any side effects or improvements.