What stage did you get the worst side effects on Mounjaro?

[purpledaze24]

I’ve been on 2.5mg for 3 weeks and debating whether to go up to 5 at the end of the month. I’ve had very few side effects other than tiredness some days and a little nausea in the first few days. I’m wondering when side effects were the worst for people? When they started on 2.5 or when they went up to 5? Or went up beyond 5?

I only went to 5mg overall but never had any side effects.

Worst for me was 10mg
I got some sulphur burps on 5 but the nausea, acid reflux & vomiting started on 10.
I don’t think my stomach liked the delayed gastric emptying.
For a while like clockwork the day after injecting in the middle of the night I was throwing up my stomach contents. After that I was alright for the rest of the week.

I only ever went up to 7.5mg and I never had any side effects at all.

I found 2:5 to 5 the hardest. I guess it’s the only step which is doubling the dose. I stayed on 5 for a few months and moving to 7.5 was fine. I’ve been on 7.5 for 3 months and considering stepping up to 10 to shift my last stone as I seem to have plateaued over the last month.

I am on 10 and haven't really had any side effects to speak of - just feeling very cold the first couple of days after a jab.

Having said that, I think it's an indication of it not working all that powerfully on me - it does work on me but not as strongly as it does on many people. My rate of weight loss is the slowest in my month thread by far.

I’m at 15mg. Had one headache when I went up to 5mg, may or not have been Mounjaro. Haven’t had any side effects.

Does anyone know if your body becomes tolerant to it after a while? So it stops having much effect and you need to go up a dose? (Even if it was working in the beginning)

7.5 was the worst for me but 10 has been a dream!

I had some gastric upset on the second and third week of 5mg, and then once whilst on 7.5mg, but both times I feel it was related to what I ate. I found there were specific things that I couldn't tolerate, so I don't eat them any more and no issues since. I moved up to 10mg without a single side effect and so I've been side effect free for many months now.

Regarding your question about tolerating the medication, I was on 7.5mg for months and eventually my rate of weight loss slowed down a lot. That's when I decided to move to 10mg. So I suppose the 7.5mg wasn't enough, eventually.

I take that back. I vomited everywhere with no warning earlier 😭 this is my 2nd month on 10mg, no idea why.

@TheBig50 so sorry to hear that. Hope you feel better soon. I ate 2 rashers of bacon this evening and have a painful tummy now 😭

I am 20 shots in and never really had side effects, except for feeling cold at first.

I think the key thing is that at 20 weeks in, I'm still only taking 5mg. I increased from 2.5-3.75 slowly over 4 weeks, and then stayed at 3.75 for 5 weeks. I'm not chasing high suppression, and I'm content with feeling hungry at meal times and wanting small healthy snacks. I no longer want to eat rubbish, and eat smaller portions. I also don't panic when I have the occasional hungry day mid week after 4 days of exercise, nor when I have two days of increased hunger leading up to TOTM. I think some feel unsettled by these fluctuations, panic that it's not working, or chase high suppression and move up the doses quickly and then experience side effects.

@PurpleCoo I think there's actually quite a lot of people who seem to view it as an admission of moral weakness to go up doses.

It just works differently for different people.

I am on a relatively high dose (10mg) but said exactly the same as you about side effects.

My suppression doesn't sound higher than yours either - different but not higher. I am not hungry for meals but I can still put away a large portion of food quite easily when I do eat which it sounds like you no longer have the impulse to.

I find the suppression goes up and down for me and doesn’t seem related to how close to the injection it is. I’m halfway through my third week and yesterday I could barely eat at all but this morning I was absolutely starving and bought a massive chocolate crispy cake (the first time I’ve eaten anything like that since I started). I scoffed half of it then felt so full and sick that I haven’t eaten for the rest of the day.

Never really got any. Been on MJ just over a year, currently at goal and on 10mg about to start working my way down to a good maintenance dose.

I had a bit of constipation when I moved up a dose and the opposite if I drank too much or ate something my stomach didn’t like (green olives 🤷‍♀️) but nothing other than that.

The vast majority of people don’t really get any side effects worth mentioning. It’s not a forgone conclusion!!

Bolded weeks (I dropped down for the next dose):

Pen 1 (2.5 mg) - 2.5, 2.5, 2.5, 2.5, 3.2 (5)(5)
Pen 2 (5.0 mg) - 4.2, 4.2, 4.6, 2.5, 4.2 (5)(10)
Pen 3 (5.0 mg) - 4.2, 4.4, 3.3, 3.75, 3.75 (5)(15)
Pen 4 (5.0 mg) - 3.75, 4.2, 4.2, 4.2, 4.2 (5)(20)
Pen 5 (5.0 mg) - 4.2, 4.5, 4.6, 4.6, 4.6 (5)(25)
Pen 6 (5.0 mg) - 4.6, 5.0, 5.0, 5.0, 5.0 (5)(30)
Pen 7 (5.0 mg) - 5.8, 5.8, 6.3, 6.7 (4)(34)
Pen 8 (7.5 mg) - 6.9, 7.5, 7.5, 8.1, 8.8 (5)(39)
Pen 9 (7.5 mg) - 9.5, 10.0, 10.0, 10.0 (4)(43)
Pen 10 (10.0 mg) - 10.0, 10.0, 10.0, 11.2, 10.7 (5)(48)
Pen 11 (12.5 mg) - 12.5, 12.5, 12.5, 12.5, 13.75 (5)(52)
Pen 12 (15.0 mg) - 13.75, 13.75, 13.75 (3) (55)
Pen 13 (15.0 mg) -

With hindsight, I think it would've been better for me to have taken 3.75 mg for at least 4 doses in pen two. The problem is it impossible to predict how you will react. 3.2 mg (the bonus dose for pen 1) was fine. My friend has been fine going up every single dose in one step, when she was ready (definitely slower than every 4 weeks though).

I felt I didn't have enough suppression on 2.5 mg and again, with hindsight, 4.2 mg was a bit to much so at the very least I should've stuck there for a while. I only stuck to it for a second dose because I was on holiday (and so glad I did!).

The knock-on effect was I was almost certainly too cautious going up and on too low a dose for me for months on end after this.