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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Anyone else found that Mounjaro isn't really working for them?

132 replies

ThumbTowers · 23/05/2025 17:26

After high hopes, I am really disappointed. Have been injecting 2.5mg for 4 weeks and now taken my second dose of 5mg. So on my 6th week altogether and have lost 2lbs. Basically nothing! I am so sad reading all of these stories about people losing a stone a month etc. And I know you need to control what you eat etc at the same time. But surely I can conclude that this just isn't a drug that's going to work for me?? I am not sure whether to bother moving up to 7.5mg to see if that makes a difference or just give up now....

OP posts:
KmcK87 · 25/05/2025 17:09

Kittyloulou · 25/05/2025 16:48

If you have to diet and exercise with this drug what is the point? You’d lose weight doing that alone. I already know it would never work for me. I don’t eat because I’m hungry, I eat out of bordem and I just love the taste of food. I eat when I’m not hungry. Calorie counting is the only thing that works for me. Costs s lot less than all these injections

Because food noise and binging can be too much for people without these jabs. Certainly was the case for me anyway

SilenceInside · 25/05/2025 17:16

@Kittyloulou your description is very similar to how I was pre Mounjaro. I was never hungry, I just ate whenever I was bored, stressed, grumpy… and it all stopped when I did my first injection. I just didn’t want to any more. I could manage to just eat at mealtimes, and a small portion.

it’s brilliant that you can stick to calorie counting and can save your cash, and presumably you’re not obese due to being able to successfully calorie count. So doubly brilliant for you. Me, I need a helping hand, and I am thrilled to be able to spend my disposable income on such a helpful tool.

Dominoeffecter · 25/05/2025 17:37

IrisPallida · 23/05/2025 20:03

This is not true.

They did not actually run any trials keeping people on 2.5mg, so there is NO evidence to say that weight loss must need a higher dose nor is 2.5mg classed as clinically ineffective. It simply wasn't tested.

If you cannot understand trial data or its language, then please don't attempt to summarise it.

How rude

AmythestBangle · 25/05/2025 17:50

@Kittyloulou whatever works for you is what you should do. In my case, MJ has made me actively not want food a good deal of the time. And it's changed my tastes, it's so weird. I was a tea drinker and I don't want tea at all now, only coffee. I was a wine drinker and I don't like the taste now. I ate a lot of chocolate because I liked the taste, and now, although I don't dislike it, I just can't be bothered most of the time. If you handed me a chocolate I'd probably eat it but I wouldn't be bothered to even walk to the next room for it. Sometimes I actually do feel hungry, it hasn't taken that away totally, but I kind of don't care. (For me it is a lot like how opiates affect me, I can still feel that I'm in pain but I don't care about it). It is extremely strange, and I think it affects different people differently.

notenoughhere · 25/05/2025 18:30

Kittyloulou · 25/05/2025 16:48

If you have to diet and exercise with this drug what is the point? You’d lose weight doing that alone. I already know it would never work for me. I don’t eat because I’m hungry, I eat out of bordem and I just love the taste of food. I eat when I’m not hungry. Calorie counting is the only thing that works for me. Costs s lot less than all these injections

It’s helped me lose weight whilst dieting and exercising. It’s made it manageable, alongside taking this I am working hard on eating 3 healthy meals a day. I have an appetite and I still get hungry, both of these are normal human behaviours though so I don’t want to take higher doses and eliminate these. 2.5mg has done me for over 6 months and I have lost over 5 stone. If I was able to just do that with diet and exercise alone I would have done it 20 years ago, obviously. There is a level of alteration in the brain and body with MJ that just makes the first and exercise manageable rather then difficult and that’s why success

knitnerd90 · 25/05/2025 19:13

There's simply no way I could have cut my intake this much without the medication, and I think there's other effects beyond just making you less hungry (the diabetes benefits, of course!) When your brain and stomach are telling you you ate hungry, even if your metabolism can't use the calories, the odds of you not listening are low. We're supposed to listen to those signals and eat when we feel hungry. When your brain lies to you, the entire feedback loop is broken.

Mysticmaiden · 25/05/2025 20:49

@Kittyloulou it does a lot more than make you feel fuller and remove food noise and help you hit your calorie goals, it reduces inflammation immensely, there is a lot of published data on its impact on systemic inflammation, cancer, heart disease and it will soon be approved to treat these conditions.
Myself I was prediabetic and have ibs and sensitive, reactive skin and it has resolved these. It's like reversing 15 years of my life and being as healthy as i was back to how I was in my 20s. Most of us have saved the money we have spent on our health, it costs approx £20-35 a week which is easily spent on junk food, takeaways, eating out etc. my supermarket food shopping has gone from £150 a month to £85 a month mainly due to the reduced volume of food and less treats. If you don't have or need any of this then that's fine and good luck to you.

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