Anyone else found that Mounjaro isn't really working for them?

[ThumbTowers]

After high hopes, I am really disappointed. Have been injecting 2.5mg for 4 weeks and now taken my second dose of 5mg. So on my 6th week altogether and have lost 2lbs. Basically nothing! I am so sad reading all of these stories about people losing a stone a month etc. And I know you need to control what you eat etc at the same time. But surely I can conclude that this just isn't a drug that's going to work for me?? I am not sure whether to bother moving up to 7.5mg to see if that makes a difference or just give up now....

Keep with it. 15 mg could be your therapeutic dose.

Apologies didn’t mean to quote!

You really need to read and be informed and avoid comparing your progress to anybody else's as it's almost certainly likely to lead to disappointment. I've seen videos where people have had substantial weight loss and stayed on 2.5 the entire time but also read how suppression doesn't kick in for a lot of people until they move up to the 10 milligrammes. If I hadn't have read that I would have been more disappointed with my slower weight loss .. My friend is on it it and she has lost weight by eating the same kind of foods that she was but just much smaller portions and cutting out snacks. whereas for me I have cut carbs. It really is very different for everyone And it does take some time to see what's best for you.

This makes no sense. Mounjaro was developed for users with T2.

Exactly

I think you have to trust the process and keep going. Different people have different sensitivities. It didn’t do much for me until I got to 12.5mg.

How does this make it a troll post. I feel the same. The point is we expected the mj to help with suppression so it made it easier to reduce the calorie intake otherwise what is the point?
I lost a lot of weight (4 stone) last year by counting calories. I put it all back on and then some. I didn’t have the motivation to do it again so I decided to try this. Others I know on it and those on this site are losing often large amounts from 2.5mg. I had zero suppression on the 2.5 and the 5mg. So doing it by just calorie counting was no different than doing it without mj, so therefore I was feeling what’s the point.

As it is op I am actually feeling suppression with the 7.5mg. Still no great weight loss yet. Only on my 2nd week of 7.5 though. I intend moving to 10 after.
Seeing people losing 2 stone etc in the early days of it (while happy for them) is frustrating in a why isn’t that happening to me way so I get it.

Thanks for understanding. Good to hear you are starting to notice a difference on 7.5.

20% of people are nonresponders to tirzepatide, but what's much more likely is that it's the dosage. It's why the dosage in the weight loss trials was 15mg. Many people need to go up to see weight loss.

I've just stopped taking Mounjaro 7.5 after 3 month's saw my GP he said it doesn't work for a lot of people and said it really should've worked by 3 months and not to bother continuing. It wasn't working for me only lost couple of llbs really gutted as cost's so much money!!!!! 😢 my hair was starting to fall out too. Really wasn't worth the money imo, but hear it can work great for others.

I'm prediabetic and found it much easier to lose once I got to 10mg. Before that I was strict calorie tracking and lost 1lb a week average but I did start at 13 stones. Obviously a person starting at a higher weight will lose much more quickly. Increasing protein, limiting carbs and drinking lots of water really does help. Tracking calories will make a difference too, work out your tdee first. I'm now 10st 9lbs but it took 7 months.

Because it’s the kind of thing trolls say about mounjaro “why not just count calories? Why do you need to take a drug?”

Although trolls also jump on threads and hijack them with a load of rubbish, so.....

My loss is very very slow - 6 weeks in (2 weeks on 5mg). 8lb down (and I weigh most days and it's very up and down). I had been on saxenda for 2 years prior and had stalled after a 2 stone loss (plenty more to lose, like 6 stone). I weight train 4 days a week and do other cardio - I'm struggling to get the balance right as the weeks I really track everything, 100g+ protein, fiber 25g, 3L water, eat clean and calorie count my loss is minimal - when I've given up and eaten too many carbs I get a big loss! Struggling if I do 16:8 to get enough protein etc and it's not touching my insane sugar cravings yet. Not quite getting on top of it but I think even slow progress is progress that I wasn't making otherwise - but it's disheartening hearing of people losing huge amounts. I'm going to give it 6 months on the 5mg as that's the plan with my doctor.

Thanks, that's useful to know. I agree, slow progress is better than nothing.

Hi, interested to see you're T2D. Low(er) carb inc no sweet tasting food may be where you are already. When i started MJ I thought I'd need three months for the loss I wanted. I had a few events due but otherwise I had to be zero alcohol. Soda water with lemon and ice in a large tumbler down the pub never looked do good.

I was good with intermittent fasting (Jason Fung books mentioned above, also Prof Tim Spector Zoe group as help) / time restricted eating. I got used to 16 or 18 hours inc sleep. For me no breakfast. Nothing before 2pm. Nothing after 9pm. Roughly.

Compared with stories I read here I've been lucky with side effects. Constipation but psyllium husk capsules from H+B help.

Never occurred to stop increasing the dose so I've gone 2.5, 5, 7.5 and 10. Purchased syringes, to get 5th shot from the pen

I am a fan of Keto and higher fat diet ok. And protein. But avoid carbs. Uncomfortable first 72 hours scaling back carbs.

Beyond that, no snacking! Ever. "I'll wait for the meal in 2 hrs etc" Not having cakes sweets biscuits crisps even fruit around wasn't too bad for me.

My crutch is black coffee. That's breakfast and more. Near zero carbs or calories. Had to scale back cups of tea. Don't like black tea. Don't buy milk but an occasional during the day coffee or tea with single cream feature. Costa will sell you a coffee with pouring cream. Yum.

Beyond that, no bread, pasta, potatoes, chips/fries, pizza, rice. Just don't buy or eat. No ketchup or sugary sauces.

I buy lots of broccoli and cauliflower. Yum. Or salad. Taken the place of chips, mash, etc. Prof Tim speaks well of sauerkraut and it's cheap. Goes with meals fairly regularly. Small amounts of full fat yoghurt. Kefir. Nice treat. Yoghurt goes with salad.

I'm single, children long since moved on so easier for me. I didn't calorie count. MJ and I dropped 50 lbs from SW just under 200.

I did really well in a health MoT. Was taking MJ at the time but the prescription comes from a pharmacy not the GP. My call to leave GP out of this detail,I admit. Due to BMI coming down weight had no issues for the first time in years. Great BP. Blood sugars good after overnight fast (but that's what i do!).

Sorry but my point is to stay with it and go up in your doses. Good luck!

It’s not a magic drug. It is scientifically impossible to lose weight unless you are in a calorie deficit. Weight loss drugs are a tool to weight loss, you still have to put the work in. Count your calories, weigh your food and exercise. Weightloss drugs will make you feel full quicker and stop food noise. If you are still eating over your calorie maintenance then you will gain not lose.
I’ve been on it since February and have lost 3 stone, I track my food, lift weights and do my steps. You still have to put the work in

The 2.5mg is to get your body used to the medication with minimal side effects.

How much weight you lose and how fast depends on your beginning weight, your diet and exercise.

1200 calories for instance could be too low. Use an app like Nutra Check to get a profile of how many calories along with macros - like protein - which is really important.

Good luck with your weight loss x

Try not to worry - I put on the first 2 weeks and was ready to give up but then lost that the 3rd week and then it kicked in once I was on the 2nd or 3rd dose of 5pm. I lost over 2 stone and got to goal in 3 months after the first month of little change. So not super fast but it worked. Once I was on 10mg I could barely eat at all and was ready to stop though. I had a month off and am now on a low 2.5mg maintenance dose which isn’t really curbing my appetite which has well and truly returned so I think 5mg will probably be right for me to avoid weight gain.

I dont have any medical evidence to back this up, just from what i have seen professionally as a nurse, and through my own experiences of using mounjaro. However, the weight loss does appear to be slower, and a higher dose needed for those with type 2 diabetes. I spoke with a medic regarding this, and they theorised a higher dose was needed as type 2 diabetics required more correction of the GIP hormone than those not diabetic. This is just opinion not fact, could well be wrong, could well be far to generalised. But we see a lot of people on mounjaro and know alot of people taking it.

My advice would be dont be disheartened. Stick with it for a few months and see if a higher dose works for you if the cost is something you can easily justify. In the mean time, make the best choices possible for you. Thats easier said than done i know otherwise we wouldnt be needing the medication. But stick with it. 2.5 didnt work for me, 5 worked a bit, but 7.5 onwards i found great and went up to 12.5mg. Im 41kg/6.5stone down and at a healthy weight a year after starting. Its not, despite what social media would have you believe, a quick fix, its an investment into yourself, and it takes time

I’m on wegovy. I was on ozempic and it didn’t work for me at all after 4 months. Switched to wegovy. Lost a lb in the first month. Am now on month 6 and the highest dose and am nearly at my goal weight and 3 stone down. Appetite reduced on dose 2.

On another point My husband is a diabetic. He lost weight on ozempic and blood sugars stabilised but He was switched to monjaro due to supply issues. His blood sugars are amazing but he has not lost any weight at all. Like zero lbs. So different drugs work for different people. Give it a couple of months and if you feel like your appetite has reduced you will be ok the track to lose weight xx

good luck xxx

I’m sure pp have already said this, but the 2.5mg is just a loading dose, it’s getting your body used to the drug.

id give it another 4 weeks on 5mg and see how you get on. Don’t forget it won’t ‘melt’ fat, it should just enable you to be in a calorie deficit.

I think there are a lot of people that don’t lose in the first month and have healthy slow losses, but these aren’t the people that shout about it. I’ve been on MJ for 8 months and lost 2.5 stone. It’s been a struggle sometimes, but a lot easier than willpower alone. Just think of it like nicotine patches, or vapes. It’s a massive help, but you still need to adjust your lifestyle

@ThumbTowers with all due respect and I say this from a place of love and with my own new found knowledge, watching what you eat is just not enough. You absolutely MUST track every single morsel that passes your lips. It’s so so easy to make “healthier choices” without actually knowing the calories. Some salads can be 1200. Some burgers with fries only 800. If you do not track you won’t win either way. Mounjaro is a tool, it’s not a magic wand. Although I do agree once you hit those higher doses it should help with your suppression. I would highly recommend looking at Team RH they have an app that you can track everything and it only costs £8 a month with support for GLP-1 users built in. You will have to weigh all your food, with or without mounjaro you would need to do this, and it won’t be forever it’s just until you learn the true calories of things and make better choices. You need to focus on protein and fibre to keep you full. They have a team you can contact for help. But my god if you don’t track, they will be down your neck 🤣 you cannot lose weight if you don’t know what you are consuming. Feel free to message me if you like. You can do this!!! Don’t be disheartened xx

I've just gone up to 5mg from 2.5, I am checking weight on the scales weekly although I'm trying not to take much notice of it really because weight can change really fast due to other factors like water weight. I maintained last week which is fine, I still know I've lost 8 pounds and my stomach has started reducing in size. I'm type 2 diabetic with PCOS, so I don't think my weightloss is going to be as dramatic as anybody else.

It doesn’t sound like you are controlling what you eat! It’s not a magic drug that does all the work. You still need to calorie count and make sure you are in deficit and exercise. If you do t exercise you will loose muscle which you will never get back!Personally I’m not sure you’re in the right mindset for this at present. I’ve been on both Wygovy and now mournjaro and have lost 3 stone in the last 18 months, not the quickest loss but I’m happy and 4 dress sizes smaller.

Hi OP, I was the same. I was so despondent after going through 2.5mg, 5mg, 7.5mg (yep!) until the effects finally kicked in at 10mg. My friend however lost 6lbs on the first dose! It’s different for everyone. I’m now down 2 stone and finally feeling the effects that everyone has described (both good and bad!) Hope it goes well for you.