Anyone else found that Mounjaro isn't really working for them?

[ThumbTowers]

After high hopes, I am really disappointed. Have been injecting 2.5mg for 4 weeks and now taken my second dose of 5mg. So on my 6th week altogether and have lost 2lbs. Basically nothing! I am so sad reading all of these stories about people losing a stone a month etc. And I know you need to control what you eat etc at the same time. But surely I can conclude that this just isn't a drug that's going to work for me?? I am not sure whether to bother moving up to 7.5mg to see if that makes a difference or just give up now....

I love this analogy @sharplily!

I’m exactly the same and my sugar / food addicted monster is dead!

I no longer need to count calories.

I’m just take it and lose weight because I eat less food and mkre healthy food and well balanced food. Basically is have a normal
healthy low calorie diet!

The clinical dose starts from 7.5, the previous doses are to help your body get accustomed to the MJ.

Incorrect.

2.5 is a sub clinical dose so if you have type 2 you might not see results until you up the dose. (2.5 isn’t enough to reduce blood sugar)

Yes as a prediabetic HBA1C of 45, it took to 10mg to correct my unstable blood sugars with symptoms of feeling ravenous, shaky, dizzy, shaking hands, headaches, feeling faint when doses wore off before 10mg and when not eating regularly enough. I'm now on 12.5mg now I can finally do intermittent fasting, couldn't do this before due to my symptoms. The losses were easier from 10mg too, before I was strict with my calorie deficit 1200 to lose 1lb a week.

The jab doesn't make you loose weight, the jab is meant to help your mentally not want to eat as much. So you still need to be in a calorie deficit and eat well.

So someone with those symptoms,but never been tested for diabetes
Finding the mj ,not really having much effect
Could be pre diabetic,and need the higher dose??
Is that possible or am I putting 2 and 2 together and getting 5

Could be, but could also not be. Not a good way to test for diabetes!

I am T2 diabetic and finding a lot of suppression and loss even on 2.5 and now 5mg.

Yes but as T2 you would be on diabetes medication already so your blood sugars will be managed by it. Those of us who are prediabetic or insulin resistance don't have any medication for it, my HBA1C was 45, if I was 48 I'd be diagnosed diabetic, i was literally 3 under the cut off and had symptoms, maybe on another day it would have hit 48 or more. This was 2 years ago and my GP never mentioned it, i only found out via the app 2 weeks ago when I switched GPs and got all my results. A lot of people are prediabetic and insulin resistant and either don't have any symptoms or have mild ones. With my symptoms I definitely needed medication but was told my test was fine. Even those who have pcos have insulin resistance so they don't produce enough insulin which is why mounjaro works for us when nothing else does because it corrects our insulin levels. Which is why we need higher doses for management.

You could ask for a HBA1C blood test to find out. I am also 43 and perimenopausal. Either way if a lower dose is wearing off, then you could try the next dose up. There's no point spwnding money and staying on a lower dose to be ravenous and it not being effective for you. I've not had side effects either other than being cold, so going up was no issue for me.

Blunt assertion. For another view, try
https://uncertaintyprinciples.substack.com/p/why-do-we-lose-weight-on-glp-1-drugs?utm_source=post-banner&utm_medium=web&utm_campaign=posts-open-in-app&triedRedirect=true

Very interesting read, thank you 😊

Definitely getting 5 from your 2 + 2

I have done 6 months in 2.5mg and reversed T2

Yes, but they only prescribe MJ if your blood sugars AREN’T effectively being managed. My HbA1C was at 79, on a super high dose of metformin, and another drug. If your blood sugars are normal on metformin, you’re going to have to do a lot of persuasion to get MJ.

What @bridgetreilly said. I was only prescribed MJ because insulin and metformin combined wasn’t bringing blood sugars down to normal levels, NICE guidelines are that MJ is almost a method of last resort and you need to have failed to achieve control with 2 or more other medications first.

@RelishingGrpSupport that is fascinating, thank you. I get very frustrated by the ‘tricking your brain into feeling full’ line. The reality seems to me much more ‘my brain actually noticing when I am full rather than ignoring it completely so I keep eating’. And that hypothesis about fuel-partitioning really makes my point about the limitations of calories in/calories out. Bodies are not simple machines, but incredibly complicated biological organisms with any number of ways of using, storing and expending energy.

No but you could get it prescribed privately like anyone else who is obese, I'm not talking about mj via nhs, I'm talking about private as I know a few who are on metformin and using mj too for better weight losses. In that case you would be like a normal responder to a low dose as you are being managed by metformin for sugars

When you said ‘you’, it sounded like you meant me, because you were responding to my experience. But apparently not.

By the way I'm T2 as well. Diabetics have better weight loss overall but seem to require higher doses. I've also never tracked a single calorie and have lost over 5 stone. So the posts insisting you must track? No. I have to take 10mg to keep my blood sugar where it should be. The American guidance (and I think Canadian) is now to use a GLP-1 before insulin because of the improvements in overall outcomes including cardiovascular.

By the way my last A1c was 5.2% (33 in UK measures). The most important thing here is your glucose.

Have you stopped it now? Just interested to here peoples experiences of what to do once they reach their target weight. I am on 7.5mg not too far off my target weight lost 65% of what I aim to loose. What happens when you reach your target weight. I am worried of a rebound effect when stop it, envisaging raging hunger as over the months my body has adapted to it.

It has been amazing stopping the food noise. I think it has other beneficial effects not all yet apparent like alhemiers risk decrease, adhd symptoms improved, alcohol cravings reduces. Game changer for obesity which is a major problem in the West, particularly. I wonder what all the biscuit, cake, ice cream and sweet makers are thinking. Are their profits decreasing?

I plan to stay on it long term, stopping isn’t really an option for me.

I have started feeling full more easily on 7.5 mg so you have plenty of time to see if it works for you. Use this time to think about and implement your strategy for reducing calorie intake .It will happen.

I don't know your experience, you never said you were prescribed mounjaro via the nhs in your previous comments. I was generalising and it was based on comments I've seen in last 8 months since I've been on mj. There are a lot of people who don't respond to lower doses due to insulin resistance, underactive thyroid, menopause etc. Everyone won't fit into that category but it may help someone who is struggling and wondering why it's not working for them.

Same for me 10mg before I felt the difference in my symptoms. Good to know about the new guidance too.

I lost 45 kg and got to my goal of BMI 22. (From 34) in November. I started on 2.5 x 4 weeks and went up the doses every 4 weeks. No real suppression until 3rd week on 7.5mg. My will power is none existent so no real weight loss due to my ‘see-food and eat it diet’.. but once I was on the higher dosages ( carried on up to 15mg) I never had to track calories as simply not hungry. In fact had to set reminders on my phone to eat. ! So although I was on it for weight loss for 9 months about 43 of the 45kg loss was achieved in 6.5 months and only about 2 kg in the first 10 weeks.

I also have an underactive thyroid and pretty obviously insulin resistant. I have been a yo-yo dieter for years , which is one of the greatest causes of insulin resistance especially when the weight regain is made up of visceral fat around the stomach. I literally looked 7 months pregnant.

I maintain on 7 mg now. Will almost certainly remain on MJ for life (or its subsequent reincarnations. )

If you have to diet and exercise with this drug what is the point? You’d lose weight doing that alone. I already know it would never work for me. I don’t eat because I’m hungry, I eat out of bordem and I just love the taste of food. I eat when I’m not hungry. Calorie counting is the only thing that works for me. Costs s lot less than all these injections