Mounjaro disappointment :(

[Stars12]

I am 5 days into Mounjaro and feeling a bit disappointed! I AM STARVING! I did lots of reading and talking with other people on it before making the decision to start. Everyone I know has had appetite suppression almost immediately, no food noise, even D&V! I have had no change at all! I am literally relying on willpower alone and still want to eat everything! I’ve even checked the pen to make sure it actually went in 🤦🏽‍♀️. Please can anyone reassure me that this has been the same for them?!

Sorry I shudve explained better I lost a stone in the first 2 weeks then it’s just tailed off to 1 off stayed same then another 1 off so for a month it’s been not a lot ! I think I thought it wud be bigger losses per week because of the jab !

It's not actually possible to lose a stone of fat in 2 weeks. You will have lost some fat but also some water. Then over the next couple of weeks the water will have been replaced in your body making the scales go up, and if you lost fat at the same time it would show the scales staying more or less the same as it balances out.
it's really crazy to see a stone drop in 2 weeks and think it's going to continue like that - that's literally impossible. You can only lose the amount of fat that you make possible via a calorie deficit, the jabs don't melt fat away by magic.

For some MJ dosnt work until higher doses , personally it did work for me but only for about 2 days the first two weeks and week 3-4 not at all, I still lost loads of water weight first 2 weeks (8lb) so just because you don’t feel it dosnt mean it dosnt work

focus on protein and fiber and as PP water water water

MJ in your system will increase over time and the suppression /lack of food noise will increase and last longer the longer you on it. I’m on week 10 and dosing between 5mg and 7.5mg but effects is now 6-7 days . I lost more on 4 weeks 5mg than I did 4 weeks on 2.5 mg

be patient it will come and meanwhile focus on healthy food in calorie deficit

Do you know what I thought this was for help & support not judgement! I’m so sorry if I’ve offended ppl with my post I think Ile stick to support from friends & family instead of coming on here thanks

I didn't read judgement in this response, more a reminder of the science to help you reset your expectations. It's still very early days for you and you've lost a lot already, when you're only two weeks into a therapeutic dose. Try not to stress about it but I would suggest sticking around on this part of Mumsnet. I've found it an invaluable support over the last 6 months.

Hello, I'm new here but wanted to ask about people's experiences as I'm totally confused.

Been on Mounjaro since January. Just moved up to 7.5mg.

At no point have I had any appetite suppression, a perceived dampening down on food noise, feeling of fullness. I can eat and drink what I want. And I spend most of my life feeling hungry. This is very disappointing.

BUT I have still lost almost 2 stone in weight.

I lost a stone when I was on 2.5mg (but I was consciously dieting) and then a further stone very slowly since February.

I'm not concerned about the rate of loss. Slow and steady is good in my view - I have another 2 stone to lose. But I don't understand how it is happening because I swear I am not eating in a calorie deficit. Am I just deluded and there is some dampening down on my food noise which I am not noticing. Or could Mounjaro have changed my metabolism which means I am losing weight despite not trying? I had blood tests done recently and my blood sugar levels are massively down (I was pre-diabetic a few years ago and now I am way below that threshold) so the Mounjaro is presumably having an effect there?

Thanks and sorry for the essay!

PS. Have posted in Mounjaro disappointment thread because I am disappointed its not 'working' in the way I expected it to.

I would recommend you log your food and drink for a few days to find out how much you are eating and if you are in a deficit.

I assume you must be or you wouldn’t be losing weight.

Mounjaro does work on insulin levels, that’s its primary purpose so it will mean you are more efficiently handling glucose to reduce its propensity to be stored as fat, but actually losing weight requires a deficit.

Thank you.

Yes I suppose I could be in deficit in that I am feeling hungry all the time at the moment i.e. I must be snacking less than usual and I have ditched breakfast.

But then the question is, has Mounjaro enabled me to snack less or am I just exerting willpower (hence the constant sense of hunger). Because its very expensive to take the injections if Mounjaro doesn't really have much of an effect on me. But I think it must have some sort of effect because I am usually hopeless at dieting.

I just wish it had all been a bit more obvious (like how everyone else seems to describe their experience). Hoping that 10mg will be the point at which I feel the full benefit?!

I will try and track calories this week and see what I am averaging.

I had no suppression until 10 mg. Lost nearly 7 stone now. Be patient. I would give it six months and then decide if it works or not

I didn’t think it had made a different at first. But it did.
MJ at 2.5 and then 5. I have not yet gone higher.

I’ve lost on average half kilo per week since I started in February. Slow and steady wins the race.
you do need to make life style changes too
Lift weights.

Watch what you eat and drink.

see if you get to 10% loss in 3 months. That is the aim of the game.

good luck

@LillyD it can be both at the same time!!

This is great to hear and wow - well done

Not fully read this post but as others have said you need to give it time.
Come back if you still feel this way at 10mg but it is likely to kick in a lot soon than that.

Op I did monjora for 6 months, as did my bf. My friend did it 2. All very limited disappointing results. It’s over hyped.
I felt as you did on both 2.5mg and 5mg - literally nothing affected how I felt about food. I did feel very tired though like fighting off a cold. 7.5mg dose I started having 1 day of vomiting and feeling like flu every week. I started to lose some weight and I felt positive like it might be worth sacrificing a Sunday every week (bonkers in retrospect). By 10mg dose I felt like I was dying. I tried going back to 2.5mg but still felt like I was dying. I lost just shy of 10kg and have come off and started putting it back on. Exactly the same as every other diet I have been on except this one made me very ill. It’s not a miracle and will not work for everyone! I really suspect it also will not show any benefits long term!
My friend felt ill very early on and gave up.
My boyfriend found 5mg made him ill but had good 2-3kg weekly weight reduction and managed to stick to it till he got to target weight. He has gone off and likewise weight is going up… He could not do the suggested (expensive) people staying on 2.5mg forever as he felt too ill for it also. He was also concerned about unknown long term health consequences after seeing how ill it made me - told me I basically had to come off it as he’d rather me and him fat and trying to diet than too ill to ever enjoy a weekend.
All the way through my own 6 months I really couldn’t understand why I felt so tired - literally like I had a permanent cold - and yet I’d lose 1kg in a week. But when I look back for me it didn’t suppress food noise and by day 4 I’d start snacking. I also stopped going gym completely due to joint pains. All pains gone now and back at gym! Going back to normal calorie controlled diet for me!
So if it doesn’t work don’t persist endlessly as it just doesn’t work for everyone!
ps I’ve read trial reports and NICE evaluation and it’s clear it’s not some magic bullet but deffo worth a shot for people like me struggling with weight most of life

People are too impatient, you should take mounjaro long term, the first few months are to allow your body to adjust to the medication and slowly increase it until you get to the higher doses.

It should take atleast 6 months to increase to the full 15mg dose, which is where you will start seeing your bigger loses.

https://www.numan.com/weight-loss/medication/mounjaro-timeline-what-to-expect this site explains it a bit better.

I will caveat this by saying I did have some terrible side effects in the first few months, but by week 15/16 I could tell I had adjusted to the medication and the worse of the side effects went away.

Op, it can be frustrating when any medication we take doesn’t work the way we hoped it would but it’s very early days for you yet and you have to give it time.

And even then it could be that you never have the reaction to it that you hear of others having, for some it really is like a fat burning magic bullet, but I’d say those people are in the minority and most of us plod along day in and day out with enough help from the Mounjaro to make losing the weight possible whilst also having to work at it.

Suppression for eg, I barely know what it is but there are things going on for me with the medication that means I’ve lost 20.5kg in 9 months on a calorie I take of 1500 calories a day. It’s a number I won’t go under for various health and reality reasons and whilst my equivalent of a pound a week may not seem like much in the world of WLI, in real terms it’s huge.

Do I sometimes wonder how others in my MN forum group have managed to lose 30-35kg for eg in the same amount of time? Of course I do, and not just because the mechanics of how all of this works is really interesting. But I have learned the only person I should compare myself to is me over the same time frame and where I’d be now if I hadn’t started the Mounjaro.

Anyway, I have about another 7kgs to lose and that won’t even take me to the top of my healthy BMI range. I’ll be about a stone away from it which for me and my frame and the fact I’m muscular is the weight that’s best for me. And going forward? I’m not worried about that at all, I’ve not even considered maintenance doses of my Mounjaro because plodding away day in and day out these last 9 months has been the best thing for me to do.

Don’t give up Op, you need to give yourself time but you do also have to adjust how you’re thinking about Mounjaro.

edited to add - until 2 weeks ago I was still on 10mg and it’s only now I’m on 12.5 I can feel the appetite suppression people talk about but I’m still on my 1500 calories a day spread out over the day just a little bit differently.

Thank you very much. That’s really helpful. I’ve reflected on the last week and actually, even though I’m feeling hungry I have managed to stay in control, eat within my calories and make better choices. I suppose for the long game, that’s far more realistic than just never needing to eat! So I am feeling better about my journey now and will keep going. Congratulations on your weight loss. I hope it’s making you feel great!

That’s a great way of looking at it! Once you’ve lost the weight you will have already learnt to control your hunger instead of getting all the food noise back suddenly.

How are you getting on @Stars12

Hi, thanks for asking!
Im halfway through my second week. I’m still hungry but I’m finding I want to eat better food and not craving the sweet stuff I would usually go for. So I have lost weight but not through suppression, more making healthier choices and mindful eating which in the long run is better, I suppose! That said, I’m looking forward to going up a dose and hoping it helps a bit more with the ‘noise’ as I’m still thinking a lot about food throughout the day.

@Stars12 that’s exactly how it is for me and has been for 9 months. In fact I just posted about it in the August starters mounjaro thread. Have a read if you have time and don’t forget you’re doing just great!!!!!

I am slightly annoyed that I’m not one of those who can’t look at food if I’m being honest 😂 How have you found the last 9 months? What dose are you taking now? Have you had any other side effects as you’ve gone up the doses? I’ve felt fine on 2.5 so am apprehensive going up to 5 incase it makes me ill!

Ah OP, I could have written this myself but please keep going! I’m on day 3 of 2.5mg and yesterday I felt like I was permanently hungry. Thankfully I’d filled the fridge with good protein foods (cooked chicken etc) and whenever I felt hungry I just snacked a bit on that. I too checked to make sure I’d actually injected! 😂 But then later I did some more reading and realised it’s also quite common for it to take a while to kick in. Obviously we read all the ‘lost 10 stone overnight’ stories but the experience for many others will be very different. I’m confident to keep going and seeing what happens the further up I go.

Stay within a calorie deficit but don’t deprive yourself as that’ll likely tip you into giving up.
And if you need to eat a bit more in the first few weeks, do it. Be kind to yourself as your remarkable body is adjusting to a new way of existing.

We will get there, I’m sure of it!

Throwing motivation right back at you!
Ive managed to surround myself with lots of gorgeous, slim, gym loving friends so apart from my very supportive partner, no one else knows I’m jabbing! They just wouldn’t get it. It’s nice to hear from other people who understand! 🙂