Can't decide whether to move up dose

Mezzoprezzo · 2025-04-10T11:12:52+00:00

I'm just coming to the end of week 3 on mounjaro. Finding it amazing! I'm consciously dieting but have so little appetite and interest in food that sticking to a calorie deficit is pretty effortless. It makes sense to stick with 2.5 for another month and have pretty much decided I will. But I've got a nagging fear that half way through the month the effect will wear off and I'll regret not going up. Has anyone stuck at 2.5 and had the same suppression in month 2 as month 1?

Time4changeagain · 10/04/2025 12:46

The 2.5mg and 5mg pen are usually the same price, buy a 5mg pen but only take half a dose (30 clicks) That way you can titrate up if you need to at a later date rather than being stuck with a 2.5mg pen.

AnnaQuayInTheUk · 10/04/2025 12:49

I found I had really good suppression on 2.5 for the first month so stayed on it but by wk 6 it had very little effect.i moved up to 5mg and the same thing happened - it was really effective for the first few weeks but then all the food noise came back.

I'm currently on 7.5mg but will go up to 10mg for my next pen and am hoping that will be enough to stick at.

FattyBumBumNoMore · 10/04/2025 13:00

I’ll be taking my 13th dose tonight of 2.5mg. In the middle of that, I had two weeks off it for surgery and I still stayed fully suppressed. If it’s working stick with it IMO but also agree with the point up thread that you could always just order 5mg if you don’t want to risk it. But don’t stress that you have to move up and the narrative of the process; 2.5 offers everything for me at the moment and it might be the same for you. Good luck!

Original poster

Mezzoprezzo · 10/04/2025 14:31

FattyBumBumNoMore · 10/04/2025 13:00

I’ll be taking my 13th dose tonight of 2.5mg. In the middle of that, I had two weeks off it for surgery and I still stayed fully suppressed. If it’s working stick with it IMO but also agree with the point up thread that you could always just order 5mg if you don’t want to risk it. But don’t stress that you have to move up and the narrative of the process; 2.5 offers everything for me at the moment and it might be the same for you. Good luck!

Interesting. I think I'll give it a go staying with 2.5mg. I've got around 5 stone to lose so need plenty of time to move up the doses.

OP posts:

Username12284949 · 10/04/2025 20:08

I am on week 4 of 2.5 and have had very little effect from it this week. I had been planning to stay on 2.5 as the first 3 weeks have been great but ended up ordering 5. I would order 5 anyway as it’s the same price and then you can continue taking 2.5 from the new pen or move up to 5 if you feel the need.

myladyjane · 10/04/2025 20:32

I ordered 5 at your stage and then slowly moved up - couple of weeks at 3.75, 3 at a touch higher. I felt ok on week 3 at 2.5 but different at week 4 so the 5 gave me options

Fatmumslim01 · 10/04/2025 21:22

I'm also in the same position @Mezzoprezzo . Just coming to the end of week 3 on 2.5 and feel like I'm ready for something a bit higher but not sure. I'm going to order a 5mg then I have the option of counting clicks to either do 2.5, 3.75 or the full 5mg

ivegotthekeyivegotthesecret · 11/04/2025 06:41

I also intended to stay on 2.5mg for the second month but ending up increasing to 3.75 by week 6 meaning I had to buy my 3rd mj sooner than later. You have nothing to lose by doing so.

The price of the 2 5 and 5 is so similar. Buy the 5! Save yourself some money and give yourself the flexibility to move up in the month if you later decide to.

northerneast · 11/04/2025 06:46

I have done over 20 weeks on 2.5mg. No jeed to change if it works. For me it’s not as effective as it was at the very beginning but I hated that feeling of trying to force myself to eat so I’m happy with the appetite balance I have now.

HeavyHeidi · 11/04/2025 07:15

I've been on 2.5 since I started in January. No need to move up if it's working.

AskingChrissie · 11/04/2025 12:31

The point is to use WLI to REGULATE appetite - not suppress it, especially to the extent you can’t eat. Suppressing appetite unnecessarily will only cause problems - muscle loss, hair loss, side effects. Losing weight too fast could actually cause more metabolic damage. If 2.5 mg is working no need to go up. The Pharma companies, whilst they have created a brilliant drug/medicine, way over prescribe in terms of dosage for most people, including “starting” dose; they also underestimate side effects (I have found this to be the case for most medicines).

If it ain’t broke don’t fix it.

Original poster

Mezzoprezzo · 11/04/2025 19:51

AskingChrissie · 11/04/2025 12:31

The point is to use WLI to REGULATE appetite - not suppress it, especially to the extent you can’t eat. Suppressing appetite unnecessarily will only cause problems - muscle loss, hair loss, side effects. Losing weight too fast could actually cause more metabolic damage. If 2.5 mg is working no need to go up. The Pharma companies, whilst they have created a brilliant drug/medicine, way over prescribe in terms of dosage for most people, including “starting” dose; they also underestimate side effects (I have found this to be the case for most medicines).

If it ain’t broke don’t fix it.

This makes sense. I changed my mind 3 times but eventually decided to stick with 2.5mg. I'm liking the feeling of being good at dieting. I decide what to eat within my calorie deficit, eat it and get on with my day. Interesting to see how long 2.5mg lets me keep that up.

OP posts:

Laura992 · 12/04/2025 05:21

Hi everyone! I am in the US and not sure if our increases are similar to yours? My Tirzepatide is prescribed by my primay medical doctor, not through an online provider. I was started on 2.5mg x 4 weeks, lost about 7 lbs, then moved up to 5.0mg x 4 weeks and have lost 12 more, now moving to 7.5 mg tonite. Depending on my next 4 weeks, I may stay at 7.5 or move to 10.0, don't know. My goal is 125- 130 lbs, currently at 171.8