I'm starting to wonder if mounjaro is making me feel depressed

[mjcausingthis]

I started about 10th September I think, I've just had to go back down to 2.5mg as I couldn't cope with not being able to eat enough on the 5mg.
Anyway, I do suffer from anxiety which I take medication for and usually it comes and goes. But the last few weeks I am so incredibly down in the dumps, I've never been depressed, it's always anxiety with me so this is new and seemingly out of the blue. I'm starting to wonder if it's mounjaro, has anyone else's who's been on it a good couple of months felt this way ?
I have literally fuck all motivation, I barely leave the house these days. Everything feels like a massive effort, I feel really, meh. Just feel shit and not myself at all!

Are you managing to maintain a healthy balanced diet? Lack of nutrition can be a cause of lack of motivation, feeling shit etc.

I try too, eat healthy meals each night, drink protein drinks throughout the day. I know I wasn't eating enough on the 5mg I physically couldn't so that's why I've gone back down now

When I order through Med Express there is a bit about MJ possibly causing depression, so I would say yes, it’s possibly that.

I am at the start of week 2 and I wouldn’t say I feel depressed as such. I some tears yesterday watching a sad TV programme - but I think I needed them (ironic).

However I do have a weird kind of fatigue. Could be caused by the end of a cold. Or it could be mounjara. I’m not sure.

For me your post is a reminder to me to stay at as low a dose as possible as long as it’s working. I will stay at 2.5 as long as I can, as long as it’s working. Maybe even go lower than that. Also, keeping up food intake i assume is important. I ate a very reasonable amount of food and still lost weight.

However, I do feel more fatigued; happy to lie in bed doing nothing which is a change but if I wasn’t retired might be a problem. I might do a post separately about fatigue at some point.

Moujaro has turned me from Tigger to Eeyore. It has flatlined all my emotions good or bad, happy or sad. The good thing is that I know it is MJ, not depression. Sadly it is a known side effect in some people🙁
I am sticking with MJ as it is working well for me, I have been on it since August, but I am on less than 5mg and plan to stay on as low a dose as possible.
Getting outside for a walk really helps with a mood lift for me.
Good luck🙂

Same here. I wonder whether it's a combination of of low blood sugar because I'm eating less and the lack of sunlight as the weather has been so appalling. I've upped my multivitamins (especially vitamin D) but I'm really struggling with motivation to do any exercise (which I used to enjoy 3 times a week). I also feel cold all the time. I just want to hibernate until spring!

I feel like the lack of ‘nice’ food is almost a bereavement that has left me feeling empty. The nice stuff that comforted me has gone and I need to find things to replace it.

I’m not in any way depressed because I’m excited about the things to come, but I can see how that could easily flip into depression.

I suffer from depression (not medicated atm but probably should be) and MJ did make it worse. But I am not sure if that’s a side affect of the meds or now not getting such a dopamine hit from food or using it for comfort.

Now 4 months in and the depression has waned a bit. It’s still there. I have less bad days but do generally have a lack of joy / can’t be bothered attitude. Need to exercise but have little motivation.

Oh gosh I'm about to start this and with 10stone to lose will be on it a while. I don't want to be depressed as I have those tenancies anyway 😬

I was wondering exactly the same. I often can’t be arsed to do much and often feel sorry for myself when really I know I’ve got lots to be happy about. On holiday in sunny Barbados and need to get a grip and enjoy the new slimmer me.

Oh gosh 😩. I have cfs so already struggle with fatigue but hoped weight loss would help.

Sorry I don't mean to scare anyone off mj, especially when it's needed for our health ! As I've said, I already have my own mental health issues which may make me more susceptible? I don't know. My mum has been on it too and she seems absolutely fine mood wise, but not alot bothers her anyway!

A couple of posters have hit the nail on the head for me, a lack of joy and motivation. And feeling flat. I need to exercise as I know it will help my mental health but Jesus, the thought of it is just ridiculous effort !! I don't feel myself, I'm not as happy, I'm irritable, I don't do much as I can't be bothered. I only have two injections left now and then I'm done, I can't go on feeling this way. I'm 10.4 now I'd like to shift that extra 4lbs but if I don't, I don't.

I started in September as well and just gone back down to 2.5 after 3.75. Was feeling a complete lack of motivation and classic depression symptoms of not finding joy in the usual things. I feel better on 2.5mg but weight loss was slowing on 3.75 and obviously even slower on 2.5mg so it's a balancing act. I've 10lbs to go until I'm a healthy weight so I'm hoping that one more pen (after my current) will get me there and then I'll just have to try and get to my goal weight by myself.

It's a listed side effect of the drug so we're not alone.

“A couple of posters have hit the nail on the head for me, a lack of joy and motivation. And feeling flat.”

This is a good summary of how I feel, not depressed but flat and fatigued.

However I don’t see a realistic alternative for losing weight for me and it’s a health priority, so sticking with it for now.

I wouldn't say I felt depressed but it did feel tired, unmotivated and just flat. It evened out the highs and lows which was good in a way as I think I used to be a bit manic and stressy but when I went up to 5mg is was too exhausted to do anything. I was lucky that I was only on it for 6 months and in that time detoxed sugar so overall feel much better since I stopped.

Lacklustre.

😬😭.
I need to lose 10 stone. I can't be more fatigued than I am for a few years 😬😭😲.

Was having this last week, it smacks your dopamine settings. It's made me massively meh about Xmas. Still enjoying stuff, but.....I've decided short term pain for long term gain right now. But not sure I'll be going higher than 5mg.

I promise that when you start losing weight it does help ease fatigue in one way- at least it has with me. Just having 3 stone less bulk to haul around make a huge difference,

It’s more of a sense of feeling ‘flat’ if anyone else can relate. I usually love the build up to Christmas but can’t seem to muster any of the usual excitement that comes naturally most years and feel a slight edge of unhappiness most of the time even though I know I’m extremely fortunate compared to many.

I don’t regret being on MJ despite the fatigue and flat mood. I’ve been losing a steady 3kg a month since September and that’s really important healthwise.

Don’t be deterred, you can always stop if you don’t like it. Like pp I’ll be sticking at the 5mg dose.

Yep, I also usually love Christmas and this year I'm like, eugh... that's so not me.
Another thing is I can't get up in the morning ! I am a morning person, always have been, I'm snoozing for an hour every morning !!

That sounds really tough !!

After another morning of feeling horribly depressed I've decided I'm not going to do my last 2 injections. I've done 12 weeks and lost 2.5stone, that's good enough for me. I now need to concentrate on keeping up the healthy eating and trying to get exercising. I can't go on feeling this way it's awful and isn't worth trying to lose the extra 8 pounds I wanted to lose.

I feel the opposite. I feel really healthy and motivated and absolutely love looking at new clothes and fitting into them.

I do find some things have changed eg if I have put on a tiny amount it really doesn't bother me when it would've been devastating on a normal diet. It's helped me gain a real perspective.

I know a few people taking it, not including people on here, and don't know anyone who had a problem with depression.

I think if you are a comfort eater especially if you have anxiety diets are very hard on you. If I felt bad my go to was cake or sweets and I'd feel better but now I can't do that so have had to find other things to do like crafts, decorating, exercise. It's a bit like giving up smoking or drugs. I really do think it's as simple as that. I have to have extra naps to cope.