Mounjaro 7.5 side effects

[loudbatperson]

Has anyone else found moving up to 7.5 really difficult?

I took my first 7.5 dose yesterday morning. Within 2 hours I started feeling really sick. In the evening I tried to eat a piece of toast but it came back up not long after.

Today I have not been able to even think about food, but tonight I figured I had to try to eat something, I made a chicken breast with a side salad (basic lettuce, tomato and cucumber no dressing). I managed maybe half a salad plates worth of salad, tried to eat chicken but I couldn't swallow the first bite. That was a couple of hours ago and since then I have been fighting to not be sick.

I was completely fine on 2.5 and 5. The last two weeks on 5 I had really great suppression, and if I hadn't had already ordered the 7.5 pen I think I would have stayed on 5 for another 4 weeks.

It would be great to know if anyone else has had a really severe reaction when moving to 7.5, and if they found it did get better in subsequent weeks, or if I would be better to just move back down to 5 at next dose?

I am struggling to even drink water, but can just about manage a small sip every half hour or so.

I just wrote a post about this today that has no replies!
I tool 7.5mg on Monday and haven’t been able to look at food since. First 2 days I could hardly drink either. It’s been dreadful. And I’ve been on 5mg for 2 months.
No solution but much sympathy.

Oh no I hope you feel better soon! This is awful isn't it?

I wasn't worried about moving up as the other doses have been fine.

Do you think you'll continue with the 7.5?

I just felt sooo tired on 7.5. Just like a slug!

I feel a good bit better. Nausea seems to have eased. I think 72 hrs is when the peak of a dose is reached, so that’s over 72 hrs now.
I don’t know whether to plow on and do 7.5 again. Not sure I can face it. Maybe a 6?

I got an extra box of needles with my first 5 pen this month. I chose to only do a 3/4 dose for the first time to see how I got on. Could you try that? Do half or 3/4 doses until the pen runs out?

I plan to stay on the lowest dose possible for as long as I am getting good suppression and no side effects. I am on Pen 1 / 4th dose of 2.5mg, suppression is good at the beginning of the week but tails off in the last couple of days. If I am getting suppression at a lower dose is there any additional benefits to moving up as that is all the medication is meant to do?

40 clicks on the 7.5mg pen will give you 5mg next week if you want to go back using the same pen.

NewDigOwner I am thinking of doing 5.5 or 6mg next dose? I have 1ml needle and syringe so can draw up what I need. Don’t think I can face another 72hrs like that. I prob ate 1000cal over 3 days. If even! Grim.
Maybe best to work up to 7.5mg. I’ve 20lbs max to lose, think I’ve knocked a few of those off the last days, haven’t weighed myself. Have lost 35lbs since April, so the weigh loss is great for me. I think I can get to goal on 7:5mg, and then stay on a maintenance dose. Deffo don’t think I could go any higher.
Thanks.
(Also apologies for ‘plow’, didn’t have my glasses on!)

I’m due to go up to 7.5 next week. I did 3 weeks at 5mg but I’ve been on holiday the last to weeks so dropped it to 3.75. I’m still getting good suppression but feeling like a slug 😂 for a couple of days afterwards so I might stick with that for a bit longer. I need to keep my wits about me as I don’t thing I’ve been performing too well at work! 😳

I seem to be turning the corner a little today, I managed a glass of Slimfast for lunch, and I definitely feel less tired and headachy at least for it.

The last two weeks on 5mg were so good for me appetite wise, I think I will move back to 5mg. It's just a shame I had already ordered the 7.5 pen before I settled on 5mg or I would have stuck there, but I will just extract 2 thirds of a dose each time from the 7.5mg.

Does anyone know if there is a timeframe the pen must be finished in after taking the first dose? I keep it in the fridge so not impacted by the 30 days unrefridgerated. I just want to check I can use my 7.5 for smaller doses until it runs out.

And thanks everyone for sharing! It is comforting in a weird way that others have issues with 7.5, although I do wish you all didn't feel so terrible.

Ginger tea or pills.
Electrolytes.
Peppermint oil pills.
Take a trip to Holland and Barret.
My daughter was same when moved to.7.5.. but wore off when she started on the above.

@loudbatperson pen should be used by 30 days out fridge or 30 days from first use whichever is earliest. You should be able to get 5 doses out of it in 30 days.

I am finding 7.5 horrendous! I can't finish anything I eat but in the morning every day I am vomiting lots and bring up the completely undigested food I had 14 hours ago!

I would go back down to 5 mg, or at least less than 7.5 mg next time. Click count to (5/7.5 x 60) 40.

I've been watching a lot of YT videos from America - the key takeaway for me is to go up the doses slow, and only when necessary. I'm currently doing a slow transition up to 5 mg (3.2 mg, 4.2 mg - intend to stay on 4.2 next week) - I may take a month to do it. Then my plan is to stay at 5 mg for as long as I can.

The antibacterial agent in the multi-dose vial in the pen is only good for 30 days from first puncture. So, you can get five weekly doses out of it. I wouldn't risk it past that even though chances are if you've been good with the hygiene (washing hands/wipes etc) if will be fine (especially as stored in fridge) it just isn't worth the risk for me. I see it as buying a pen with 5 doses and if I need to write-off some at the end of the pen, to be safe, then that is fine.