Sheldon from big bang. In the show it’s funny but in real life he would have no friends whatsoever and after a while that starts to grate. He was vile.
Interesting this gets more than one mentioned here. It’s widely acknowledged that Sheldon (in fact, most of the characters) would probably score high if tested for Autism. The creators have said they’ve left it open to interpretation, but most would conclude it is the case. Calling him vile, and not worthy of having friends is what happens to many autistic people, but thankfully there are others who do see past the traits of autism and can see the person beyond that. The show is well written as nobody lets him get away with every terrible thing he does, they call him out often and his response is often to apologise and that’s that. When you view Sheldon through the lens of autism, I’d hope you’d have a different take on it.