I have been watching the Handmaid's Tale while also re-reading a book I read as a teen, The Chrysalids by John Wyndham.
Lots of resonating themes, dystopian worlds in which an aggressive and oppressive extremist Christianity is a threat to the sympathetic characters.
In the Chrysalids there is a post-nuclear world in which any slight mutation is considered to be a mark of the devil and anyone with six toes, longer than usual arms, or whatever is sterilised and forced to live in the "fringes" a polluted and dangerous area like that depicted in the Handmaid's Tale.
I wondered whether anyone else had read the Chrysalids? It is a bit dated, the word "queer" pops up a lot to indicate strange things, but still an interesting story.