Yes. New clothes have formaldehyde in them. The stuff used to preserve dead bodies. It stinks and it’s bad for health. It helps prevent the clothes from becoming wrinkled. There’s also antifungal and anti microbial treatments on the clothes, and dye excess. I wash new clothes and towels etc because of the stink, the chemical coating feel of the fabric, the health risks and I have sensitive skin that gets itchy from new clothes. Also goodness knows who else has tried on the clothes and what was on their body. All new clothes and towels, sheets, etc are washed a minimum of two times before using and put outside in the sunshine to dry and air out.
If something was dry clean only I wouldn’t buy it. If it was an absolutely important item to have like a suit jacket I’d hang it outside in the sunshine for a day to help reduce the smell.
I wouldn’t buy something that needs ironing to look good, like a heavily pleated skirt, so no I wouldn’t wear something like that without washing it.