I've not read all the replies so it might have already been asked but I hope I'm going to come at it from a different perspective to some.
There is clearly 'something' going on for her.
But it is true that this behaviour is extreme and would suggest to me an incapacity rather than just not caring.
If she works, she is clearly managing some aspects of 'normal life'.
I'd be curious to know what form the conversations have taken when you've previously spoken about them?
As a possible solution, I'd suggest sitting down and discussing as equals. Not as you asking her to be different or why she does or doesn't do x, y or z or telling her what she needs to do but suggesting a solution you are both part of. What shall.we do first today? I'm going to do X, what are you going to do? Set a timer - 30 mins with you both doing something that needs doing.
Establish a routine. Eg all bedlinen is stripped on a Saturday morning and washed. Make it a non negotiable. That will feel overwhelming and excessive to her to start with if she hasn't changed it since Christmas. So maybe aim for fortnightly to begin with.
Urine bottle is emptied out before work.
Whatever else is needed.
Make lists, tackle issues one at a time, make them specific (eg strip bed, empty bottle) rather than tidy/clean your bedroom. Don't try making or expecting big changes in one go.
Build in rewards (that she has chosen). Not because she's a child and needs incestivising like one but because we all feel better if we incentivise ourselves with rewards for little wins - mine is always a cup of tea in the garden when I've finished a task I didn't want to do! For some people it's a new book, lipstick, cake, a glass of wine, watching a favourite programme whatever.
Part of the problem is that when things become so big, it's hard to know where to start or even see the smaller incremental stuff.
I once worked with a woman who told.me she was in £35k of debt but she had just spent £3k on a sofa becaise she fell in love with it. I asked her why. She said that, when you're in that much debt, it just becomes numbers and what's the difference between £35k debt and £38k? (Er, £3k more debt?)
It didn't make sense to me at the time but I got home and looked at my kitchen table that was covered in crap. When the table is empty, one coffee cup stands out and has to be moved. But when the table is covered in crap, one coffee cup isn't even noticeable anymore.
There is a reason why she is like this though. Until you address that or find a way of working together to improve it, it isn't going to change.