Hi. We have to go look at houses tonight, so I'll get back to you tomorrow, I promise.
SF to Portland isn't my idea of a road trip. I think the journey is around 10 hours or so, the traffic in SF is horrible, depending on what time you're there, and the freeway in California has to be about the most boring stretch of road I've ever been on in America. And while we don't drive to a lot of destinations, we usually fly and then get a car and put a lot of miles on it.
If you wanted to take several days and go up highway 1, it is pretty and there are some cute little towns, but the road is pretty windy and adds a lot of time to the trip. For me, even if I did that, it wouldn't be worth it. There really isn't much you're missing except for a view.