TTC no.2 after successful IVF for no.1

[Chocoholic85]

Hi,
I’m just after some advice and to see whether anyone is in the same boat!
Just found out that my 3rd FET failed.
We are very lucky to have DD who came from our first fresh transfer. We were also very fortunate to get 5 frozen embryos from that round so have been trying for a sibling. 1st FET was BFN, 2nd was a chemical pregnancy/early miscarriage and 3rd now is failed. Down to the last two and starting to feel the pressure and also wondering why on earth it isn’t working?!
We have unexplained infertility so nothing was ever found with our initial tests and I was 34 when we had out first IVF round so odds were in our favour. I read somewhere that at 34 around 50% of embryos are abnormal so I guess out our 6 maybe the last 3 were all abnormal. I’m also worried something has changed since I had to have a csection for DD. I did have an ultrasound which showed the scar had healed fine and there no niches, I’m wondering if there are adhesions that might not have been seen on the ultrasound though.
Would love to hear any advice for what to do next or from anyone else in a similar position. Thanks x

How is everyone doing?

They wouldn't let me go ahead with another transfer straight away, so am waiting on my period now and then prep for another transfer which I think will be mid month - this one will include the evorel patches from the start which I'm really hoping will help, and they also want me on prednisoline this time, as well as the baby aspirin, clexane, lubion and progesterone pessaries.

We have two day 5 embryos of grades 4AA and 3AA and 3 day 6 embryos of 6AA ,5AA, 4BB.

Have to keep reminding myself that it took four transfers to get our daughter, but I also had a chemical and a miscarriage on #2 and #3 before her so that felt more positive in a way.

SO hard to stay upbeat and also just continue trying to be a good wife, mother, daughter, sister, friend, and employee at the same time etc etc!

Hi ladies

Sorry I've been awol, just catching up on everything.

We did transfer #7 of trying for a sibling last week and tested this morning and bfn. We did down regulation for this one and everything went smoothly. I just can't believe it hasn't worked again. I don't know what more we can do.

I met with prof quenby in Coventry last week who basically said the protocol we were on was what she would recommend. We could do the deft testing for my lining with prof broadens which I think is our next step but that means doing a mock transfer cycle and probs no transfer before Christmas.

I'm just gutted, I really thought it would work this time. I don't want to stop but I don't know if I can keep putting us through this.

DD just asked me why I was crying in the bathroom. She talks so much about having a brother or sister and I'm so desperate. How is it right that people who don't want a child or mistreat them get pregnant and here we are giving absolutely everything including financially and nothing.

I just can't believe it.

@Eggling I'm so sorry your transfer wasn't a success. I know exactly what you mean about how unfair this whole process is and how hard it is to keep going. I went to my clinic yesterday to get started on our next FET. Got all my medication and when I got home received a phone call to say I couldn't proceed as my bloods showed an issue with my thyroid (this has never shown up before). So now I need a whole bunch of investigations with the GP and medication to bring my TSH down into range before we can transfer so it's looking like the new year for us too.

After my stillbirth in May this was the only thing getting me through and now I just feel at rock bottom again!

I'm sorry @Hopefullyonedaysoon. It's just shit upon shit isn't it.

I just wish we could find a reason.

I'm really sorry both. Tough news all round. @Eggling it must be so frustrating feeling like everything was optimised but it still didn't work. Seven transfers is so much to go through. I can understand the temptation to go with more testing etc but the delays must feel so difficult. The unintentional guilt trip from DD must feel so hard too. Ours went through a phase talking about it a lot last year and I found it really difficult when we were going through our failed cycles at the time. Nothing I can say to make it better really, just to say I hear you and I'm sorry xx

@Hopefullyonedaysoon how frustrating for you too. Especially when it's not been an issue until now. Is it a known potential complication from being on fertility treatment drugs? Or do they think it's unrelated? So sorry, what a pain to have yet more delay for you too.

@loulamay how are you getting on? It is such a struggle managing the fertility stuff plus life. Totally overwhelming at times. Hope you're okay

@Faith2024 hope your scan went okay x

I am so sorry @Eggling . I can’t imagine how hard it is. You are doing the best and the most you can. Is there anyway you can do something just for you until your transfer? May not do anything but just a thought.

Hi @SErunner . I had my 12 weeks scan last week and all looked good. I did have a slightly worrying result from the combined screening even though it was ‘low risk’ the Down syndrome was 1 out of 152. The cut off point was 150. I called my clinic and the consultant called me back, she was confident in the PGT-A but said no science was 100. It was probably fine but I could do NIPT for a peace of mind, which I did late last week. I got results today of low probability, 1 in 10 000 for all 3 so I am feeling reassured. Nothing is 💯 but it’s the best news for now.

I hope all is going well with your pregnancy.

@SErunner apparently nothing to do with the fertility stuff, no one seems to know what has caused it but can occur after pregnancy, GP has given medication but had no interest in finding the cause...there's a surprise!

I know the thread is very quiet but just wanted to share a little bit of hopeful news - had my first scan yesterday at 7w3d and baby looking perfect with a nice strong heartbeat. I know we have a very long way to go but it was lovely to get some good news for a change! x

@loulamay congrats!! This is such lovely news after such an arduous journey 💕I’m so happy for you!

Congratulations @loulamay !! It’s amazing news. Wishing you a safe & happy pregnancy from here onwards.

Such lovely news to hear @loulamay ❤️ that's a huge hurdle to have got over. Really hope things continue well for you. Was this one of your DE embryos? Hope everyone else is okay?

Hello everyone, just thought I’d drop in and see how everyone is doing? @loulamay@Faith2024I hope things have continued well for you?

@Eggling@Hopefullyonedaysoon@Edfthinking of you all and hoping there has been some positive steps since your last updates?

I hope it is okay to share that we welcomed our son in March. We’ve had some ups and downs but are of course incredibly grateful he is here safely.

Lovely to hear from you @SErunner and huge congratulations! How is it being a family of four?

I'm 32 weeks and have a planned c-section booked at 39 weeks so the countdown is on! We're having another little girl. Just started digging out the baby clothes and muslins etc and my house looks like a launderette 😂

Has been a bit of a rollercoaster pregnancy to be honest - high NT reading at 12 week scan which led to a CVS test and two fetal echos - luckily all fine! Then some weird blood results showing I have antibodies in my blood from a past transfusion, luckily low level but bit of a worry while we waited for results, and then 28 week scan had her on the 10th percentile so they got me back in a few weeks later - happily she'd had a growth spurt and is now sitting around the 50th. Quite looking forward to it all being over and her being here safely. Would love to never have to think about IVF or pregnancy ever again. 😜

Hi @loulamay & @SErunner. Lovely to hear things are going well for the both of you. Congratulations @SErunner on the birth of your son. What beautiful news.

I also had some ups & downs with a few hospital visits during and after but all worked out in the end..We had our baby girl in early April. She arrived via scheduled C section at bang 39 weeks. Surgery went very smooth and peaceful, a healing experience compared to the emergency C section I’ve had 3 years ago. However recovery has been slow & I am just starting to feel OK.

@loulamay the prep is the exciting part. Enjoy it. We are also done with having kids and are very grateful for our two.

glad your birth was so great @Faith2024 but sorry recovery has been slow! Any reason in particular that you're comfortable sharing?

@loulamay I had unexpected high blood pressure a day after giving birth which they thought might have been preeclampsia but wasnt. And it was hard to manage the blood pressure as none of the meds they prescribed worked. I never had blood pressure issues my whole life nor am I overweight or have any of the risk factors for it. Anyway I spent 5 days post c section at hospital and then nearly every day at triage the following week. Finally one surgeon on call in triage prescribed 1 pill that did it. And because of stress/lack of rest I still had a lot of pain around incision & some gaps in stitches and GP was worried it may be infected which meant more meds.

It’s all behind me now. My baby smile lights up my day. And my c section experience itself was peaceful and beautiful and that’s what I will remember.

Wishing you a really positive experience x