Starting first injections of Buserelin, anyone else?

[Wispin]

Did my first needle tonight was so nervous was about to inject myself when I dropped the needle, had to get it ready again, then I just paused when I had to inject myself hovering the needle over my stomach, I couldn't mentally do it, it was like being in a dream where you cant run any faster, I held my breath and did it, I didnt feel a thing, not even when I pushed the liquid in. Will keep posting how it all goes, would love to hear from other people..

otd official test day
dp days past
et egg transfer

its over for us. 10 mature eggs. Zero fertilisation.

Ahh bean hunter I'm so sorry...did they say why?...was sperm mobility ok?Maybe next time they will try isci ..We are here for you xx

Aw beanhunter so sorry to hear that 😟

Husbands sample was fine. Going to see consultant now. Not sure why at all.

Ah thats not nice. So sorry beanhunter, nothing i can say will make u feel any better.

I hope they can shred some light on what the problem may have been.

Sperm numbers or mobility may have been poor in this sample despite showing as ok on original semen analysis.

Perhaps they will discover the eggs were too tough for the sperm to penetrate and recommend ICSI for you.

Will you be able to do this all again?

His sample was fine. They analyse it on the day to check anyway.
There's a 1% chance some may have fertilised and they are just ahead of schedule but they think that's not likely because all of them look the same. I'm heartbroken. I knew we wouldn't necessarily get a baby out of this but I didn't expect not to get to transfer after going through stims and ec is devastating.
They would only do it again if we had icsi. We can manage to finance it but I have to think if emotionally we can afford it.

It seems so odd that none fertilised.

Did you have Embryoscope so they look at the footage frame by frame?

I suppose we all take for granted that we'll get an ET like you said.

When i had ICSI i assumed that they would all fertilise seeing as they were injecting each egg. I was wrong, as the egg can just chose not to divide cells and multiple!

Some believe the process of injecting the egg is to harsh and the egg will fail as a result.

So much contradicting information it is difficult to know what is best.

They don't go into the embryos cope until after proven fertilisation at my clinic. We were hoping to have it.

What exactly dos your comsultant say?

I'm sincerely gutted for you.

How have you and tour partner taken the news?

:( I was hoping that embryscope may tell you if the sperm died off really quickly or whether they were just desperately trying to get into the outerzone of the egg and just failed.

I so like answers to these type of things, what was the hurdle!

Or whether some made it through but the eggs and sperm unfortunately then just didnt do its thing.

No really answers. Met the consultant and the senior embryologist. Went through cycle and they can't pinpoint anything they would particularly change other than we would only be allowed icsi if we went again. They will send some samples of culture medium and sperm off to make sure no infection - that's their policy with failed fertilisation.

Eggs are apparently "oval" and they feel maybe look a little tired this morning. Sperm looked good when went it - they said based on numbers they would never have contemplated icsi upfront. Sperm have got through the cumulus but no evidence of binding to zp at all.

Only thoughts are that if we go again to have icsi and consider having short protocol to minimise risk of ohss and to make it a less drawn out process psychologically. They wouldn't want to go again Until at least July period.

They said they can't rule out lab failure but they didn't change any culture medium or procedures and everyone else from last 48hrs has had good fertilisation.

So will be phones first thing tomorrow and if by any miracle there's one or two then they will go back tomorrow.

We are beyond devastated. We have conceived twice before (we have a nearly 4 year old) and so fertilisation was never anticipated to be out problem. I can't stop crying.

Ahh bless

I would be no different if i was you.

It is soooo tough going through this process and my last two failures left us both in disbelief, shock and a sense of hopelessness.

However I'm pleased they have given you a breadown of the sperm making it through despite not binding. I say this because hopefully this means they can look a sperm fragmentation or whatever it is called.

Hopefully now investigate whether the eggs were genetically ok.

:(

Ok so 9 are still totally crap. The 10th is now 2 cells but the embryologist thinks it might have just been the egg dividing spontaneously rather than fertilisation. Senior will review it at 9 but I think they want to see what it does and aren't hopeful.

Day 5 on stimms (gonal f), went for first scan today. They want me to increase dose to 375 as i have lots that are quite small and 4 described as good size.

I would normally ask measurements but he was struggling to see my left ovary and was pressing down on the cervix, which was painful.

Back for another scan Monday.

Feel so sleepy today, probably just the weather and the car journey to and from the clinic.

Plus getting up early and then going to work after.

On way for my nxt scan and bloods x

Another 3 days of stims- go back on monday- ec hopefully wed or fri nxt week x

What size are the follicles now smurfy? And how many now? Xx

Good luck stimming ladies, hoping for nice juicy follies

I started stims on Weds! And even weirder, my baseline follicle count has gone waaay up and has a PCO appearance - so consultant has put me on a mild dose of Gonal-F (150iu - compared to the sledgehammer dose of 450iu I was on before when I had a piddly few follicles)

And he got me to start Cetrotide the same day (instead of starting a few days into stims as usual) because he didn't want my ovaries to go off like rockets

Terrified of being on such a piddly dose that it won't do anything. Even though my ovaries now seem to be full of follies. Consultant seems confident with a baseline of about 15-20 follicles we should get a decent crop of eggs. But who the hell knows with my body

I was PCOS
Then all my eggs dried up
Now I seem to be PCO again

Never bloody know with my body!

bean thinking of you xx

There were about 11-12 and ranging from 9mm-15mm x so staying on bemfola 225 until
Monday and see whats what then x

Wispin how are u getting along?

Test day for you on 16th Monday, have you resisted the temptation to test early?

Yes I have resisted....I have a on off slight pain in my lower right groin sort of area...I dread wipping myself I won't look and just flush it away....I've had some little bubbly butterfly sensations....I'm drinking water like a tap is connected to my mouth...I'm trying to do nothing just sit or lie down ...

Oh god i know that feeling of not wanting look when you wipe.

First failed icsi cycle i started to spot/bleed with still a week to go before official test day.

Proper bleed didn't occur until after i stopped taking pessaries.

On my frozen cycle i didn't bleed or spot or anything, so really thought it had worked. Obviously it didn't but the point is .. not bleeding wasn't a sign that i was pregnant like i expected.

I have had a lot of clear mucus, the amount i would expect during 3-5 days leading to ovulation. I called the nurse and she said it was just the drugs. Still a little worrying that come EC i will have nothing there. This process makes you crazy I'm sure.

Hyland EWCM is a really really good sign

It means the ovaries are producing lots of oestrogen which means the eggs are getting lovely and mature, and your lining will be thickening up

It is a very very good sign

The Cetrotide stops the oestrogen from triggering the LH surge so you absolutely cannot ovulate!

I think i was just worried the perhaps the dose wasn't high enough.

The dose of Cetrotide isn't variable. It's fast acting to prevent ovulation. It's used in PCOS women where levels of oestrogen go through the roof and it still prevents ovulation

You absolutely will not ovulate on Cetrotide