Ivf anyone starting stimms next week?

[naty1]

Im starting stimns next week for icsi(dependent on blood test)?
Anyone at the same time want to join.

Ive only had 3 day transfers, as did Dsis.
That must be so frustrating about the fertilisation rate.
My clinic seems to do day 3 if less than about 4 still going.
Both my sis 2 left over embies made it to day 5 to freeze.
I think its usually about 50% maybe. The adv of day 5 would be you would know how far they are getting and how they look at that stage so you have more info for another try if necessary.
My DD was conceived from 1 good embies and a not very good 1 that they just put back just in case so 1 definitely can work and what with the one at a time thing. Also here freezing is expensive.
Do you know the follicke sizes? Were they over mature or do you think it was just unlucky.

I missed taking a pill so made it up asap hoping it makes no difference.

Good luck

Glad you're not stressed about missing the pill.
Not sure why we have such a poor fertilisation rate
Some women on internet seem to have been told that addling LH could improve fertilisation rate.

My Dr actually suggested to up Menopur from 150 to 300 at start of cycle (to try to get more eggs; not to increase fertilisation rate). But I decided against it as I got the best quality embryo on 300 Puregon and 150 Menopur in the past and thought higher dose would just fry eggs.
Gave me hope that trying this next time will improve fertilisation - and hopefully get more eggs.
But now I look at my history, I got my best fertilisation rate when just on Puregon without any Menopur! Very confusing.
Of course, I hardly ever produce many eggs 3-6, so it's hard to know as I don't have a big sample of eggs each time to see and the fact that one or two more fertilised on just Puregon could be coincidence.
Going to do more Dr Googling as I think I will feel better if I have an answer and can fix it for next time.
Hubby and I decided we are going to do day 5.
All past transfers were day 2 so at least this time, we can see what's going on instead of never knowing when we get BFN.
Read that male genome kicks in on day 3 so if it is top quality and then goes downhill after day 3, will need to work on husbands diet!
Am just so drained off all this and the thought of going again is too much.
Always thought issue was DH's sperm.
But research I read shows poor fertilisation rate points to the egg.
Very disheartening as I can't produce new eggs like hubby can sperm!
Sorry for long rant - very emotional times!
Nurse will call today with update.

I think although it says its the egg. I also had low fert rates 25% and 50-75% (due to 1 abnormal).
I agree though as the numbers are small its difficult to draw a conclusion.
I think they should move towards all being blasts as it gives more info. However i was allowed to put 2 embies last time but would have only been allowed 1 blast i think maybe the 2 embies in that scenario are better chance.
Im now over 35 so not sure what the rules will be now., they were using it as a cut off.
Hope the embryo is growing nicely

So you've added the spray to your routine now.
Is that part of the down regging to purge your brain of its hormones?
Curious about other peoples protocols since mine never seems to work out very well.
Seems downregging is standard protocol in England as everyone on Mumsnet is doing it.
My embryo was at 5 cells yesterday (day 2) when I called.
They didn't mention the grading.
Haven't heard anything since.
They are supposed to call tomorrow (day 4) for time of day 5 transfer.
Suppose they would only call earlier if it's game over.
So perhaps no news is good news!
I read 80% of embryo's make it to day 3, but only 30-40% to day 5.
Today is only day 3, so there's still time for things to go wrong!

Well its great that its still growing.

I think they shouldnt use the long protocol, spray and pill so much because it is really draining - every 4 hrs , much worse than the injections. Also it takes so long
Day 19 pill (7days)
21 start spray (14 days before but continue till trigger)
Blood test
Start injections around 14 days
Op
So think 49 days to op , about 65 days in all to pg test for me.

Its so difficult to plan childcare and anything else so far in advance

Not been online for a while and I see it's all happening!

I can't wait to see how you both get on.

My donor has finally been found, I have a rare blood group which was hard to match but she has black wavy hair and green eyes just like me, I can't believe they managed it! I would have been happy with any colouring really but she's a perfect match. I just wish I could contact her and offer support during her journey.

But I have you two to follow and keep my fingers crossed for in the meantime :)

Suzy thats great sounds like a good match.
Will they just let you know the date she starts treatment?
Or would that be more an egg share?

So great to hear from you suzy
I've been thinking of you and wondering how you're getting on
She sounds like one in a million, your blood type, your hair, your eyes.
When does it all start happening?

My protocol is from day 20 nat.
It seems like a long time to get an answer.
But these 5 days and waiting for a telephone call each day to see if my embryo has survived another day have been the longest yet!
So last update was that my embryo was at 5 cells on day 2.
Got a call yesterday which was day 3.
My embryo was at 10 cells!
I forgot to ask about grading but I read an article online that said research shows the number of cells in a day 3 embryo is more indicative of a viable embryo than the grading.

It said the embryo should be 6-10 cells so that got me super excited with mine being in the top of the range at 10 cells
I can't help but be a little excited now and worry I am just going to come crashing down hard when this doesn't work out.

Great news.!

Was all packed for transfer today when I got a phone call.
Embryo arrested overnight.
I said to Dr at start of cycle I wanted to do everything my way so if it fails, I can at least have peace that I gave it my all and move on.
But now all I want to do is work out why fertilisation rate was so pathetic so I can fix it and try again.
I just can't let go.

Oh no!
So it made it to over 4 days. Then stopped.
What size was it still cells or a morula?
Does that mean its the sperm issue or that it just falls into the percentage that dont make it.
Could assisted hatching help.

You do know something though - no need to worry about implantation issues or what you did or didnt do after transfer. (Also no taking the progesterone)

Oh I'm so sorry I don't know what to say :(

I'm just really upset for you x

Thanks suzy. You're right. There's really nothing that can be said.

Nat, I was told it was 12 cells and compacting.
Not sure if it was a sperm issue, an egg issue, or just bad luck.
Will make an appointment with my IVF dr and see what the embryologist notes say.
Have to get answers as to why only 1 in 5 fertilised.
Feel I need to correct that for next IVF to up my odds.
Of course, it leaves me wondering would the embryo have survived better inside me rather than a petri-dish and did I do the right thing waiting for day 5 transfer instead of day 3.
On the other hand, if it was going to happen anyway, I am glad it happened in the lab where I can know exactly what went wrong rather than have it inside me and be hopeful until my period arrived.
I would have been left wondering if it was a lining issue or what went wrong, where as now I know the answer.

sorry sorry shellster xx

*so sorry shellster xx

Thanks so much bessie.
I've got an appt with my fantastic IVF Dr tomorrow.
Hopefully she will have some ideas on what to change next IVF for better fertilisation instead of just one, and I can walk away from that appointment feeling more positive for next IVF instead of dwelling on this failed one.

im so pleased your feeling positive shellster - thats a good thing, i hope you get the answers your looking for hun xx

I hope your appointment goes well and you find out more.

If they recommend using a donor are you open to the idea? I am worried about how far you will go with this Shellster

Thanks bess.

I have decided that donor is definitely not for me suzy.
Don't worry. I have a stop point.
In my mind, I have decided I will keep trying until age 40.
Just pushing hard in the meantime as I know how quick fertility drops in these last couple of years before 40.
Don't want to look back with regret and say I didn't give it my all.

YOU ARE SOOOOOOOOOOOOOOOOOO STRONG (not to mention, must be loaded) YOU sooooooooooooooo deserve that BFP.... blooming heck girl, good on you.

its great that you know you have a stopping point. you are definately giving it your all. good luck with you appt today xxx

Thanks bess
Not sure if it's strength, but more just the fact that I can't handle no for an answer! The pain of saying 'I quit and I'll never hold my baby in my arms' is more than the pain of saying 'How could I improve on this IVF for next round'.
Not really loaded either! My husband is paying our mortgage and I am working hard to pay off the credit card from this IVF and save for the next one.
Ended up working today so had to re-schedule my appt to next Thursday. A bit disappointed as I was keen to walking out of there with a plan for my next IVF. But I suppose the extra time to reflect might allow me time to come up with more questions and suggestions to put to my Dr.
Forgive me bes if I've spoken to you before about your story, but if I have, I can't remember. Do you mind if I ask what brings you to the infertility thread?

aaahh your a fighter, you sound like you have enough fight in you and you deserve the very best outcome. the time til next thursday will definately help. i wish you all the best.

i havent spoke to you before, altho "seen" you about on the infertility board. i have pcos, my hubby has low count/morph ect ect. ttc for 3 years, 1 miscarriage last year, nothing since. we are starting IUI next month. i want to try every avenue and not jump in with both feet. so many docs appear to just push ivf, but he suggested iui first. we shall see. im very hopeful (on good days) so i cannot simply imagine going thru what you have. sending big SQUEEEEEZES x

Can't imagine the devastation of miscarriage after it taking so long to conceive. Keep me posted on your IUI. Today is day 25 of my failed IVF cycle. I would like to have a one cycle break and then try IVF again. I have just turned 37 and have seen the stats on how quickly fertility declines between 35 and 40 so don't want to waste any time. Will see if the Dr agrees. We too have been trying for 3 years.

Are you on a high dose of stims? Could that affect quality?
Also you said ideally you didnt want to go to the monday for EC because of something dropping do you think that made a difference.
I hope you get some explanations

How is everything Nat. Where are you at with your cycle?

Thanks for thinking of me and trying to come up with solutions for me. I have recently realized what MIGHT be the cause:

First two cycles:
Mature Eggs Retrieved Eggs Fertilized
1 1
4 3

Second two cycles:
Mature Eggs Retrieved Eggs Fertilized
3 1
5 1

So the first two, I had 4 of 5 fertilize and the second two, only 2 of 8. The one difference being that I took Puregon only the first two cycles and a Menopur and Puregon combination the second two. So it seems logical that this could be the reason. Will see my IVF Dr next week and hoping she is happy to put me on Puregon alone next IVF. At least it will give me some hope of improvement next cycle. My period is due any day so by the time I see my Dr, I will be in to next cycle. Hopefully I can start IVF again the following cycle as I am not getting any younger!