Hello silver, the best person to consult about chemo. would be your oncologist (I am assuming you are asking for yourself - apologies if your question is on behalf of someone else 
). Various factors will come into play - what type of chemo you are having, how many cycles, what your general health is like, and how you react.
I know people who have worked while on chemo, - sometimes at a reduced level (fewer days etc.), sometimes they have had part time jobs anyway. I didn't work while on chemo - because I was quite ill while on it, - but I was on fairly intense chemo - with close together cycles.
There is a reasonable chance you will be able to work going on the experience of people I know. But you should be aware that you can't really plan for this to be the case. The effect of chemo tends to be cumulative, so you may find as you go through the course, it becomes more difficult.
The other major factor to consider is the risk of infection, at a certain period during your chemo cycle (approx. 7-10 days IIRC) you are very vulnerable to infection, and an infection would put you in hospital. So you need to bear that in mind, depending on what your work is, - whether you come into contact with lots of other people or children for example. If say you are self employed and can regulate what you do according to when you feel well, - I would think working would be very doable.
I hope that's helped a little bit. Everyone has different experiences, - there is a lot of individual variation in how people cope with chemo, so it's hard to give any kind of definitive yes or no regarding work.
Good luck with your treatment, - and do ask about anything you think we might be able to help with