My DD is 20 and she has been on sertraline for a year now - best thing she ever did she is a different person - she is so much more confident, able to go out the house without me, socialise with friends and not cry or lock herself in the toilets at work any more. She suffered with anxiety for several years before seeking help from the GP when the anxiety was particularly bad she has no appetite and often was actually sick. She has never been a small girl but she was probably around a size 14 before sertraline now she is on sertraline and has an appetite her weight has ballooned and she is probably more like an 18. I don't know how much she weighs but at a guess i would say about 14/15 stone. But she is so happy and she now has a massive appetite. Me and her went away a few weeks back so I saw her naked and in bikinis a few time and her whole body is full of stretch marks and flab. However she is so happy in herself now. Can sertraline make you put on weight? Or is it more the fact that she now has an appetite. She is in such a good place I don't know what to do as she honestly isn't bothered about her size. She doesn't eat particularly healthily or do any fitness although her anxiety is so much better she still spends alot of time in her room in her bed rather than being active.