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Combining mirtazpine and sertraline together.

2 replies

Universitydilema · 10/09/2026 18:45

My mum has been suffering from extreme anxiety for the last 3 months. My dad has terminal cancer and obviously this is an incredibly difficult time for her. She was prescribed mirtazapine by a very unsympathetic GP and told her it was just tough if it doesn’t work. We’ve been backwards and forwards 3 times over the last 10 weeks to the GP. She has been on mirtazapine for 9 weeks and she has seen no improvement. The GP suggested stopping mirtazpine with immediate effect (basically going cold turkey) but I was worried about her doing this so in shear desperation I booked an appointment with an online Psychiatrist. He was the first person to really listen to my mum and took alot of time listening to all her symptoms - I know she was paying but he instantly put her at ease. He was horrified that a GP suggested stopping mirtazpine and told her to continue taking mirtazpine (15mg)but to add sertraline (25mg) too. Has anyone tried this combo ? Should she worried about serotonin syndrome combining 2?

OP posts:
redsky21 · 10/09/2026 18:48

I have been taking 200mg sertraline and 30mg mirtazapine for 7 years. Works brilliantly for me where other antidepressants didn't.

JojoButBetter · 10/09/2026 18:54

Hello, sorry your mum is suffering.

I was on Venlafaxine & Mirtazipine together. I am now on 150mg Venlafaxine taken in AM and 30mg Mirtazipine along with Promethazine in PM. I sleep so well, and sleep really help's when going through such a bad time.

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