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Mirtazapine

11 replies

LuckyManifestations · 02/09/2026 03:11

Has anyone else had side effects from taking Mirtazapine that are not listed in the leaflet?

I have been taking it for 8 weeks now, and after the initial side effects of being absolutely wiped out, sleeping all night and most of the day wore off, I am now what I can only described as being 'wired'. I can function better than I have for years, never need to nap in the day, rarely feel tired before bedtime and am so much sharper over all.

I also have lost over a stone as very few foods now appeal to me, my food noise has gone so I am able to make better food choices.

Lastly, I feel like I have had a personality transplant 😵
I have never been a naturally empathetic person and I have struggled understanding other people's feelings all my life. I now seem to have clarity and understanding in these areas, and genuinely care much more about other people.

I have read at length about this medication and haven't found any links to any of the above.

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GarlicSomething · 02/09/2026 03:19

No, but I'm envious! I've been on it for years and sometimes take a double dose if I'm unduly anxious. It's never been anything but soporific and calming for me. I gained weight after starting it - that wore off, but it hasn't made me lose any.

I'd love the side effects you describe! In fact, are they side effects or just effects?

LuckyManifestations · 02/09/2026 03:25

GarlicSomething · 02/09/2026 03:19

No, but I'm envious! I've been on it for years and sometimes take a double dose if I'm unduly anxious. It's never been anything but soporific and calming for me. I gained weight after starting it - that wore off, but it hasn't made me lose any.

I'd love the side effects you describe! In fact, are they side effects or just effects?

Its funny you should ask that becase a quick chat with Chat GPT has said the same thing - that the feelings I describe are the medication working, not side effects. I hadn't thought of it like that.

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Comeonbabylightmyaga · 02/09/2026 06:30

I loved mitazipine. Because I was finally sleeping everything else in my life was better.
I did put on weight but needed to and it was because I finally had an appetite.
Mentally it saved my life.

Superscientist · 03/09/2026 08:41

Have a look at hypomania and see if that fits with what you are experiencing.

I'm bipolar and without mood stabilisers antidepressants cause my mood to switch from depression into hypomania/mania

kookieCrumbles · 03/09/2026 08:46

I had a similar experience. Felt wonderful, had energy etc.
Turns out I have bipolar disorder and antidepressants had induced mania.

ClassActress · 03/09/2026 17:06

Maybe it depends on the individual, your personality etc. but I have been on mirtazapine a very long time and this doesn’t fit with anything I’ve ever heard about it. The first thing I thought of reading this was hypomania. Maybe it is just it working but I would go back and get this checked out with the doctor who prescribed it.
Mirtazapine is notorious for being sedative and causing weight gain/ increased appetite. It doesn’t always do this but I have discussed being on it with dozens of people over the years and literally never heard of anyone experiencing weight loss and increased energy levels on it.
When ADs work, you just feel like your regular self before you got ill. You shouldn’t feel like your personality has changed or your energy/ mood levels are higher than what’s baseline for you.

FreddoBRIDGE · 03/09/2026 21:13

Superscientist · 03/09/2026 08:41

Have a look at hypomania and see if that fits with what you are experiencing.

I'm bipolar and without mood stabilisers antidepressants cause my mood to switch from depression into hypomania/mania

That was my first thought too

BunkBedsArePeopleShelves · 03/09/2026 21:28

I hated mirtazapine. I put on two stone and didn't even sleep much better. Still regretting the six months on it, two years later.

LuckyManifestations · 03/09/2026 23:21

Superscientist · 03/09/2026 08:41

Have a look at hypomania and see if that fits with what you are experiencing.

I'm bipolar and without mood stabilisers antidepressants cause my mood to switch from depression into hypomania/mania

I looked it up after reading the comments on this thread. It doesn't seem to fit. I am being very productive, sleeping very well for between 7 and 9 hours each night. But definitely not manic or restless or irritable.
I will mention it at my next review though.

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LuckyManifestations · 03/09/2026 23:23

Im sorry to hear that.
Its odd isnt it that we all experience medications differently.

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LuckyManifestations · 03/09/2026 23:28

ClassActress · 03/09/2026 17:06

Maybe it depends on the individual, your personality etc. but I have been on mirtazapine a very long time and this doesn’t fit with anything I’ve ever heard about it. The first thing I thought of reading this was hypomania. Maybe it is just it working but I would go back and get this checked out with the doctor who prescribed it.
Mirtazapine is notorious for being sedative and causing weight gain/ increased appetite. It doesn’t always do this but I have discussed being on it with dozens of people over the years and literally never heard of anyone experiencing weight loss and increased energy levels on it.
When ADs work, you just feel like your regular self before you got ill. You shouldn’t feel like your personality has changed or your energy/ mood levels are higher than what’s baseline for you.

I hear you. Ive read about extensively, and only just found a brief article about a very small percentage of people who experience loss of appetite and/or changes to personality.

I have been on and off various medication for anxiety and depression my whole adult life with varying degrees of success, but nothing has worked for me like Mirtazapine has.
I can't ever remember feeling this well.

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