I microdose psilocybin (mushrooms). I was diagnosed with Bipolar disorder and CPTSD around 18 years ago. Up until Jan last year when I had a full breakdown resulting in a three month inpatient stay, these conditions were relatively well managed with medication and very few episodes.
I've been microdosing now for around three months. No matter what combination of medication they tried, my depression just hadn't lifted and I was so anxious that I was housebound and unable to travel in the car etc.
Since I've been microdosing I've got my life back in a way I couldn't have imagined. My psych was incredibly wary of me trying microdosing and rightly so said they couldn't stand over my choice but agreed to have more regular appointments with me since I started it to monitor for any signs of psychosis returning.
I wouldn't jump into it blindly, it's not without its risks and you need to really research every credible piece of information you can find.
I don't regret starting it. I haven't had a panic attack since I started, my brain fog has lifted, my memory has improved and I've actually been able to leave my house to go and do things for the first time in nearly 18 months.
I haven't had any negative effects. At the correct dose you shouldn't feel any remotely "trippy" sensations. The ideal dose is sub perceptual.
It's with watching "How to change your mind" on Netflix. There's a lot of research to show that microdosing and mushrooms have been hugely beneficial for treatment resistant depression and also in improving quality of life in cancer patients.