I've been taking 15mg of Mirtazipine for about 8-9 months. No real issues with it. Recently I asked if I could increase the dosage as I was feeling extra anxious. The GP agreed and I've been on 30mg for the past month. I don't know whether its a coincidence but ever since upping my dose I've had chronic IBS but thought it was down to other things. I'm now convinced it's the higher dosage messing with my gut. It's really getting me down as it's painful and debilitating and I feel like I want to reduce the dose again. Has anyone experienced gut or digestive disturbances with Mirtazipine?