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Vortioxetine - experiences?

15 replies

EmmaEmerald · 21/08/2023 19:08

Hi all
I have been on fluoxetine for years but switching to this now, the fluoxetine probably stopped being effective a while ago.

does anyone have any experience of it? Quite nervous re nausea etc.

OP posts:
EmmaEmerald · 21/08/2023 22:12

Bump for evening folk

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EmmaEmerald · 23/08/2023 00:25

Another bump for the late night crowd?

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broccolibush · 23/08/2023 00:37

Changed my life immeasurably. I had tried almost everything out there for hideous depression and I started taking this in November last year after a psychiatrist recommended it. I’ve gone from being mostly non-functioning to being able to do stuff. I still don’t lead a normal life by any stretch of the imagination but I am streets ahead of where I was in my ability to care for myself, engage with others, manage basic daily activities etc.

The only side effect I’ve had is an increase in sweating, which is pretty grim when it’s hot. But I’ll take that over the intense suicidal ideation I was experiencing any day and twice on Sundays.

I literally can’t sing the praises of this drug enough. It’s probably saved my life.

EmmaEmerald · 23/08/2023 01:20

Thanks broccoli

sorry you had such a hard time though. Doctor mentioned sweating. But going online, the main report seemed to be nausea, which worries me.

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broccolibush · 23/08/2023 01:27

Obviously I’m only a sample of one but I didn’t get any nausea, and I have terrible tummy issues (former anorexic) so if any side effects were likely for me I’d have thought it would be that.

EmmaEmerald · 23/08/2023 10:01

Thanks broccoli

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Springcat · 26/03/2024 14:48

Hi ,guys , hopefully you might see my message on this thread
I've just been prescribed this ,and I'm wondering whether to take it or not
How are you finding it

EmmaEmerald · 26/03/2024 17:29

Hi @Springcat

I couldn't tolerate it. I had really bizarre joint pain and it went on for ages - over a month I think.

First I woke up feeling as if I'd lifted heavy weights. Then it extended down my shoulders to my elbows to my wrists, and almost as if I had repetitive strain injury or something. Of course the GP told me it couldn't possibly be causing that 🙄

The leaflet made it very clear that joint pain was a potential issue.

The main concern the GP had - he said people experienced excessive sweating.

I took it in the few hot days we had last summer, but even those days, didn't have that problem.

I finally gave up on it because after it built up in my system, I had a run of a few days where I burst into tears within a couple of hours of taking it. It was complex because I wasn't in a good state but sometimes you can tell what's an emotional reaction and what is caused by a pill.

And I had been perfectly fine when I woke up in the morning on all those days.

I wouldn't let my one experience put you off. It is just one experience, obviously plenty of people take it and find it really helpful. It does work differently than other SSRIs.

I think the difference is in how it affects dopamine? My GP did say it was one of the lesser known medications.

I actually requested it, but I now can't remember why.

I can see I posted on here about nausea - no issues with that.

it might work for you as well as it has for others. Is there anything in particular that worries you?

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Pierrederesistance · 06/10/2026 09:00

I know this is a relatively old post but it's the most recent I could find about vortioxetine.

I have horrendous health anxiety and I'm due to start this at the end of the week (for treatment resistant depression but hopefully a knock on effect with the anxiety).

I had been told it would be venlafaxine and I got so many great responses when I started a thread on that, but have now been told vortioxetine would be better.

I'm so nervous about the dizziness, the nausea and vomiting, all things I suffer from anyway.

Is anyone currently on it?

Yorkshireteaalwayswins · 06/10/2026 16:49

Pierrederesistance · 06/10/2026 09:00

I know this is a relatively old post but it's the most recent I could find about vortioxetine.

I have horrendous health anxiety and I'm due to start this at the end of the week (for treatment resistant depression but hopefully a knock on effect with the anxiety).

I had been told it would be venlafaxine and I got so many great responses when I started a thread on that, but have now been told vortioxetine would be better.

I'm so nervous about the dizziness, the nausea and vomiting, all things I suffer from anyway.

Is anyone currently on it?

Hi @Pierrederesistance I tried vortioxetine in July this year and I was really hopeful. The doctor recommended it for me as sertraline had killed my libido. Reddit was really helpful for me; I get the feeling this medication is bigger in America than here as no one I mentioned it to had heard of it. It gets loads of praise on Reddit and I really wanted it to work but sadly it didn't for me. Not the positive post you want, I know, but remember its different for everyone and there's no reason that it wouldn't work for you.

Pierrederesistance · 06/10/2026 18:01

Yorkshireteaalwayswins · 06/10/2026 16:49

Hi @Pierrederesistance I tried vortioxetine in July this year and I was really hopeful. The doctor recommended it for me as sertraline had killed my libido. Reddit was really helpful for me; I get the feeling this medication is bigger in America than here as no one I mentioned it to had heard of it. It gets loads of praise on Reddit and I really wanted it to work but sadly it didn't for me. Not the positive post you want, I know, but remember its different for everyone and there's no reason that it wouldn't work for you.

Thanks so much for replying - was it the side effects that made you stop?

Yorkshireteaalwayswins · 06/10/2026 19:37

Pierrederesistance · 06/10/2026 18:01

Thanks so much for replying - was it the side effects that made you stop?

It just didn’t work for me at all, I never improved. I only had a little bit of nausea so I can echo that side effects don’t affect everyone the same. It’s worth giving it a try, as I said the Reddit site was useful though it’s called Trintellix on there as that’s the American name.

Pierrederesistance · 06/10/2026 20:44

Yorkshireteaalwayswins · 06/10/2026 19:37

It just didn’t work for me at all, I never improved. I only had a little bit of nausea so I can echo that side effects don’t affect everyone the same. It’s worth giving it a try, as I said the Reddit site was useful though it’s called Trintellix on there as that’s the American name.

You're absolutely right, it does seem to be much more popular in the US. I'm a bit wary of going down the Reddit rabbit hole as my health anxiety is so awful. I'm sorry it didn't work for you and hope you've found something that is a bit better.

Ultimatemurdermystery · 09/10/2026 21:28

Did absolutely nothing for me.

started low and tritiated to max dose and absolutely no positive effect on me.

started on lithium and my life changed.

psyche drugs affect people so individually and there is no rhyme nor reason why some work for some people and not for others!

frustratingly you just have to give them a go and see how they do / don’t work for you.

Pierrederesistance · 19/10/2026 15:38

Yes, you're absolutely right - different for everyone. I have started it now but to be honest, I'm really scared of side effects. Seeing GP tomorrow 🤞

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