Anyone been on higher than 225mg? been on venlafaxine for about 10 months, gradually increased to 225mg. The most recent increase was in Feb from 150-225. I find the increases helpful and then I flatten out again. This last 6 weeks I have been really, really struggling. I'm reluctant to increase again as Ive read they are so hard to come off. Would a 37.5mg increase make any difference? I've really nose dived with depression and anxiety. Lost my beloved pet of 12years last month and it's really hit me hard. Or should I try ride it out? (sighs)