Been successfully taking Citalopram for many years, which generally seems to be the initial first line med. nowadays. Of late it hasn't seemed quite so effective. Have previously tried a number of other SSRIs. GP's view is that, as we age, meds' effectiveness may also change - sounds reasonable to me.
GP has now switched me to Efexor XL (Venlafaxine) - SSNI class.
Not seen any posts on this drug here. Would welcome thoughts, but so far it seems very good (been taking for 1 month, 75mg, straight switch-over from Citalopram 40mg).