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novavax vaccine trial - anyone else?

996 replies

Frazzled2207 · 12/10/2020 14:39

Have just had the call and am going tomorrow. Very excited. Anyone else doing this?

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Daftapath · 13/11/2020 07:47

The One Show had Sarah Jarvis (the TV GP) doing a piece about taking part in the trial. Her husband also took part.

I noticed last night that the injection site has a small hard pink lump, like a mosquito bite. Pretty sure it wasn't there a couple of days ago. I'm only 11 days post first injection. This morning it's smaller, more like a pimple

Torvean32 · 13/11/2020 14:40

I had a small lump after the second one @Daftapath. It's weird the first injection really hurt and i had no bruise or swelling.
The second i barely felt and i had a lump and bruise.

Whoever mentioned that they took a photo of their injection syringe. How did you manage that? I wouldn't have thought that the study would be too happy with ppl doing it?

andadietcoke · 13/11/2020 18:09

@Torvean32

I had a small lump after the second one *@Daftapath*. It's weird the first injection really hurt and i had no bruise or swelling. The second i barely felt and i had a lump and bruise.

Whoever mentioned that they took a photo of their injection syringe. How did you manage that? I wouldn't have thought that the study would be too happy with ppl doing it?

@Torvean32 It was me. I asked if I could to show my children, she said yes. No drama! The liquid is covered with a label - you can't see the contents at all.
MrsHamlet · 13/11/2020 18:14

Tomorrow's the day! Phone call today to check I was still going and to warn me I'd have to wear a mask for the whole appointment... unlike when I had 32 teens breathing at me for two hours this morning, then!

GreenPlum · 13/11/2020 23:25

Has anyone had to defend their decision to take part in the trial?

To start off with I didn't tell anyone until I'd had the first injection. Then I told people slowly and really expected my friends and family to be polite about it. While I got a bit of praise and thanks and a few questions, the comments that said I was very brave etc. I interpreted as their disproval. Fine, they were, as I expected, polite at least.

Anyway, today a friend of a friend called who wasn't so tactful and told me I'm talk of the town and they're all very surprised I've done it and a doctor friend of theirs said I must be mad and what if I react badly and get really ill bla bla bla.

FFS! I just said "Why would I get ill? Nobody in the earlier phases of the trial became ill. I've done a lot of research and I know what I'm doing." That shut her up a bit, but I can't stop thinking about it.

Just wondered how you're all doing in this regard.

The comment that pisses me off the most on social media is that the vaccine (there are lots, but whatever!) has been rushed. I'm pretty good at attempting to debunk that opinion with a pre-scripted list!

I say "Obviously I did loads of research and read up on the results of phases 1&2 of the Novavax trial. Loads of doctors and a couple of the doctors I follow on Twitter are in trials which was very reassuring. So far there are no concerns over its safety. People’s main concern seems to be that it’s been rushed. The developers have got to this stage so quickly for a few reasons.

Firstly China shared their research and the DNA profile of the virus in January so other scientists around the world could get going straight away.

A lot of the ground work was done already with the sars and mers vaccine work. They had a massive head start.

Because of the nature of the pandemic and the impact it's had, they’ve been able to get the amount of volunteers by the 100,000s they need super fast. Unheard of before.

They haven’t had to spend years applying for funding. Governments and huge corporations are throwing money at them.

The regulatory bodies are putting all covid vaccine studies at the front of the queue so they’re not held up waiting in line for approval.

There’s (at risk) parallel production in place so they’ll get to market asap.

So, yes, a lot of short cuts have been made but none of them comprising on safety."

It seems people don't know much about it, which is fine. It's mega technical sciencey shit. But they're happy to spout and repeat whatever they hear, just so it looks like they know something. "Er, you won't catch me having that. It's not safe."

Fuck off! What do you know?!

Sorry! I'm just feeling very judged.

Everybody wants an end to this shitstorm. A vaccine is the only way out before more lives are lost, ruined. Our economy, our nhs are unrecognisable.

Someone has to fucking test it. At this stage it's more for efficacy than safety.

I probably got fucking saline anybloodyway.

It's late! Thank you for getting this far! x

Frazzled2207 · 13/11/2020 23:32

Of course you’re right and I suspect most of us on here have similar thoughts!

I haven’t had anything like that but have only told a few people, not including my mother who would likely freak out (but she freaks out about quite a lot tbh). A few people haven’t said anything but but most have said “ooh so good of you to volunteer” or similar. I honestly don’t see it as a big deal, I get possibly 50% chance of having immunity over the winter, what’s not to like ?!

I worry about so many people refusing to have the vaccine and saying it’s rushed etc. I accept it’s not 100% safe but is probably safer than getting covid. And society will be depending on as many as possible of us to get vaccinated as soon as we possibly can in order to beat this. I have little patience with the anti-vax brigade and will probably not be terribly polite next time I come across one of their kind.

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Daftapath · 14/11/2020 00:37

I have had pretty good responses generally from those who know. One friend on FB had posted something about not touching a vaccine with a barge pole. I think his wife is a GP so not sure what her reaction is. I didn't engage.

I thought my parents would freak so didn't tell them until afterwards. My dad was a complete surprise and said it was marvellous and he would do it too if he could as it was so important. A couple of friends have said that they could never do it (think they have health anxiety) most have just said well done or thankyou.

I have never signed up for anything like this before and when a friend signed up for another vaccine trial earlier in the year, I thought I couldn't do it as my kids would have no one if I wasn't around ie if something went wrong. With this one though, I decided we are quite far down the line of testing so it seemed fairly safe (fingers crossed!) and this has affected so many of us in many ways

Noranorav · 14/11/2020 08:37

I hadn't thought about the reactions of others but it became clear that some people though I was bonkers! I did alot of explaining about Stage 3 trials (because I had done a lot of research!) and the safety of them - because I think it's important people understand! My close friends were so lovely and said very brave (don't think it was - informed decision on my part) some of them have gone onto to have a trial vaccine themselves. There are people that won't participate and I completely get that, to each their own and it's clearly individual risk etc but for me it's about wanting a return to some kind of normal life and a vaccine is part of that - we just can't without it whilst people getting it can overwhelm our health system! I'm pretty healthy so it felt like the right decision.

BG2015 · 14/11/2020 09:08

I told a few people after I'd had the first injection. Colleagues were very interested and supportive.

My parents knew as they had signed up for the trial too but not heard anything. My uncle is a bio chemist so has a bit of knowledge about drugs/vaccines etc and he explained a bit about how this vaccine works which made my parents put their names forward. They're both really disappointed they haven't got onto it.

My DP was a bit worried but he knows I'm my own person and won't have done it without researching and thinking it through!

I'm proud to have done it even though I've just spent 48 hours with obvious side affects. But woke up this morning feeling fine.

Small price to pay.

MrsHamlet · 14/11/2020 12:40

First appointment done.
My aunt knows as do some friends but I've not told my parents or my sister. My mum would worry, and my stepmother would go even more hysterical - dad doesn't need that stress!

andadietcoke · 14/11/2020 13:27

I told immediate family but I also made it clear that I'd done my research. I work in healthcare research so I think that reassured them too. I've had a few people thank me or say I'm brave when it's come up but I haven't really broadcasted that I'm doing it. Most of my close friends are medics and find it hilarious that I still think my side effects could be down to the placebo effect and a tiny amount of saline.

Vargas · 14/11/2020 17:25

My friends have all been supportive, but DH's work colleagues think I'm bonkers and he is bonkers for 'letting' me do the trial. Hello feminism. My DM (despite very sciencey background) said she hopes I got the placebo 'just in case'.

My second appointment is now confirmed for next week. I will try very hard to determine the colour of the liquid Grin.

MrsHamlet · 14/11/2020 17:34

I didn't look. I'm convinced I got the real one because something made me fancy a cycle ride this afternoon - that's not normal and must be a side effect 🤣

Daftapath · 14/11/2020 19:33

@MrsHamlet

I didn't look. I'm convinced I got the real one because something made me fancy a cycle ride this afternoon - that's not normal and must be a side effect 🤣
GrinGrinGrin
Torvean32 · 14/11/2020 21:14

Thanks @andadietcoke, our was realky secretive. Like the tray was put out of sight. Then the nurse confirmed details. Then she went behind you to do the injection, so I saw nothing.
Initially i only told closest family and friends. Then i put minimal stuff on fb encouraging ppl to sign up to the registry vacaccine. Upon this I got some interesting messages from certain family members. I ignored these as usual..
I enjoy hanging out in vaccine and science groups in FB, you get the craziest anti-vaxxers there.

Bearsbearsbears40 · 15/11/2020 17:00

I had my first jab on Friday morning. The overall process was pretty smooth, the swab wasn’t fun but wasn’t as bad as I’d imagined. All the staff were lovely. I got a negative test result by text at 6am this morning! I have felt slightly off this weekend, nothing you could call COVID, I don’t think, but I’ve felt quite fatigued and just a bit...not 100%. It a bit mind blowing to think I may have actually had the real one!

ramblingsonthego · 16/11/2020 11:54

I have just had my first vaccine. All went well until the medical and the dr thought she heard an irregular heartbeat. So an ecg and more tests but all ok in the end. Phew!

So thats me and my husband both in the trial. He has had 2nd vaccine already so is way in front of me.

Frazzled2207 · 16/11/2020 13:29

@ramblingsonthego
Gosh! I guess you got the real thing. Pleased all is ok now.

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ramblingsonthego · 16/11/2020 13:34

[quote Frazzled2207]@ramblingsonthego
Gosh! I guess you got the real thing. Pleased all is ok now.[/quote]
Thanks Frazzled, we are both glad to be doing a small thing to help. We did try and get us on different vaccine trials but no others in our area recruiting, just to spread the chance of one of us getting a good vaccine.

The only bad thing was I didn't get a thermometer or a ruler! I feel screwed. And definitely no biscuits or tea down here.

Daftapath · 16/11/2020 14:47

@ramblingsonthego was the heart murmur thought to be heard after the vaccine/placebo was given?

I didn't get a ruler or thermometer either and must try to remember to ask when I go back next week!

Torvean32 · 16/11/2020 19:04

@Daftapath are you doing the sub-study where you record any reaction via an app?

My physical exam was intense i got referred and have had an abdominal ultra-sound. I had a load of bloods. I need one more test and ive been referred to a couple of ppl.

I've been asking my GP for this test for over 4 years and been refused. It's not even an expensive test, and i dont need a hospital stay. It would answer so many symptoms.

I'm so greatful for the consultant ( at the vaccine clinic,) i saw him once has listened to me , and thinks it's worth testing. The Gp had told me they could not provide the test. 1 letter from a Consultant and suddenly they've worked out they can, and i can pick up the stuff any time.

Daftapath · 16/11/2020 20:58

My sub study is testing immune response and just involves extra bloods.

I had very high bp when there and they had to keep retesting to get it within their accepted range. The consultant came in the end and looked at the readings I get at home and agreed that I have white coat syndrome and was happy. I have taken it again a few times so I can show them next week as, no doubt, it will be high again! Hmm

Daftapath · 16/11/2020 20:59

@Torvean32 I'm glad that you have now been referred on for your tests. If nothing else, signing up for the study must have been worth it for that!

Torvean32 · 17/11/2020 15:35

It's great @Daftapath my Gp refused me something last week. Now a consultant asked for it and they've already arranged for it.
I've had bad care from my Gp service so signing up has unexpectedly helped me Smile

Vargas · 17/11/2020 17:13

That's great news @Torvean32! Shame about your GP.

@ramblingsonthego - I have a heart murmur but the doc couldn't hear it, she tried and tried. Glad to hear your ecg was fine.

I'm so thrilled the other vaccine trials are working out well, sounds like there will be plenty of vaccines to choose from and hopefully plenty for everybody, not just rich western countries.