novavax vaccine trial - anyone else?

[Frazzled2207]

Have just had the call and am going tomorrow. Very excited. Anyone else doing this?

[Potter53]

@Frazzled2207When I threatened to just go and get the jab that my doctor was asking me to go for the man who was telling me that I couldn't be unblinded decided that he would ask a doctor to call me. When the doctor called he took seconds to actually unblocked me so it does not take long if you actual l get someone who knows what they are doing.
I have an appointment this morning so I am going to report this because experiences like this could be a reason that some people are dropping out of the trial.

[Frazzled2207]

sorry ,you're welcome too!

[PleaseReferToMeAsBritneySpears]

I've name changed so didn't get a mention 😂

[Frazzled2207]

New thread alert!!!!
see you there
@andadietcoke
@Daftapath
@Torvean
@Vargas
@Potter53
@Torvean32
@BG2015
...and everyone else welcome of course

www.mumsnet.com/Talk/coronavirus/4162058-Novavax-vaccine-trial-part-2

[Frazzled2207]

will sort!!!!

[Daftapath]

@Frazzled2207 we are nearly out of space!

[Frazzled2207]

oh dear @Potter53 that sounds very wrong. We were told as @andadietcoke suggested no problem with unblinding and in fact they seemed to recommend it if we got called up for Pfizer/AZ in the next few weeks (most of the people there when I was there were in their 60s and a bit anxious about this).

[Daftapath]

They have a separate team for unblinding as all the medics working face to face with us 'trialees' (lead consultant, doctors and nurses) are all blind too. Hence a double blind study.

[andadietcoke]

I was told last week that they can unblind within an hour - the example given was that if your GP surgery rang and offered you a last minute appointment.

[Torvean]

I dont know how long it takes to unblind somebody. But i think tbe Dr on call would have to do it. K dont think tbey were exoecting to do it due to volunteers or ppl getting leftover doses. They expected it to be planned NHS appts.
The talk of Novovax isnt confirmed but its April at the latest as far as i know.

[Daftapath]

I was told at my appointment yesterday that I should call them if I was offered an nhs vaccine before the next trial injections. So they know that some people will need to unblind in the meantime. Odd that the person you spoke to in the phone got it wrong

[BG2015]

So how do they unblind you then? Especially if time is of the essence and you're called because of left over vaccine?

If I get a call before the second round of injections and they refuse to unblind me I won't be happy at all.

I'm a 52 year old asthmatic teacher. I want the vaccine if it's offered to me,

[Torvean]

I got told the rules over unblinding ppl over the phone has changed. So no idea if that's why the volunteer got it wrong.

Ive always thought i got it as i had side effects. It'll be embarassing if i had the placebo and this time i get worse/ or no effects.

Im happy to continue as I'd prefer Novovax over Pfizer or Oxford. 2 more injections not so much fun.

Im assuming they'll call as my next blood appt is not til June

[Potter53]

Novavax did not want to unblind me when I rang this morning, the man on the phone to!d me that I could not be unbounded until the end of the study. I said that in that case I would simply leave the study and take up my doctor's invitation to have the jab because I heard on the tv that having 2 different vaccines would not cause harm. He then said he would get a doctor to call me to tell me what my options were. The doctor did call me and unblind me over the phone. I will still go to my appointment tomorrow because I know that they need to keep checking blood to see how long the antibodies last. I am not sure if I would do this again in the future after my experience today.

[Potter53]

I did think that I might have had it because on the way home after the second jab I became very shivery and my arm was so sore that every time I lay on that side in bed it woke me up.

[andadietcoke]

@Frazzled2207 no concerns at all - happy to help, and gives me full confidence that I will actually have had the active vaccine at some point. Excited to stay in the trial and hopefully stay involved in some of the sub-groups they have planned for the autumn.

[Frazzled2207]

@andadietcoke
me too!
How do you feel about being jabbed again given that you are fairly certain you had the real stuff?

[andadietcoke]

@Frazzled2207 I'm really excited to compare and contrast 'v2' reactions with those from the autumn.

[Frazzled2207]

@Potter53
Good to hear - did you suspect either way? I am convinced I had the placebo as I had zero side effects, not even a sore arm.

[Potter53]

I have been unblinded because I was called to go for my first dose of whatever the doctor is giving and I was given the Novavax vaccine not the placebo. I will continue with the trial because they obviously need to see how long the antibodies last

[Vargas]

This is all so interesting, thanks so much to those sharing info. I have my next appt in 2 days so will let you know if I hear anything different from what has been said here about the crossover.

[Torvean]

Im just back from my blood test appointment.

They've made more changes so more paper work.

The interesting thing is Novovax are talking about giving the vaccination to those who had placebo. But they still want to keep it blind. So 2 mire injections for everyone.

When the volunteers newsletter came out it said they had to unblind a lot as there was a high level of health care professionals involved.

[PleaseReferToMeAsBritneySpears]

Thanks for the feedback. Great news!

[Daftapath]

Just returned from my appointment. They confirmed that the protocol is changing to a crossover study and anyone who has not been unblinded already will be asked to take part. I signed my new paperwork so ready to go when they are.

The new protocols are still going through the ethics process. They hope to know more by the end of March but obviously to call before if I get offered a different vaccine in the meantime. Next appointment is early May but she suggested I call them at the end of March if I hadn't heard anything about the vaccine appointment .

She confirmed that we would get some sort of certificate, they would contact our GPs about us getting the vaccine and that the next injections would also be three weeks apart as per the first ones.

So exciting!

[ItsSnowJokes]

I really really hope we all get the vaccine soon (if we haven't already had it). I am back on the 8th March for my next blood test, hoping they have news then.