Immune/NK cells pred thread #33

[Jecca88]

Hey Guys, starting a new thread as we have run out of space - hope i have included everyone and sending lots of love x

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Oh it’s very scheduled @Gizmo1983 we go to beckenham place park in south London and they have a lake there - it’s really nice esp when it’s hot outside.

yeh I was tempted too, also could fit it in with a trip to Athens 🥰

@Jecca88 I've been having scans and bloods every other day pretty much. Quite intense but I'm feeling okay generally! Egg collection is tentatively booked for next Wednesday, will confirm it on Monday. I'm quite scared but excited too.

I 100% agree I HATE it when people say 'as a mother' like come on, we're all capable of empathy. Its so annoying and excluding. I also find is so difficult around preg friends. My best friend and I were pregnant together and we were on holiday together in Spain and I miscarried and she carried on to full-term and now has a 10 month old. It still stings now despite how happy I am for her and how much I love her baby.

@Gizmo1983 Its not awful at all, its so normal and natural to feel like you want to protect your heart after everything you've been through. I would be the same. I also don't want to register with midwives again haha if it happens. After my ectopic surgery they phoned me twice a week apart asking me where I was for my 12 week appointment etc even though I'd cancelled all the appointments. You're not ungrateful you've just been burned by the MC grief a lot and are protecting yourself.

@Objectiontime well done for not testing - its so hard! Good luck with your betas this weekend and your scan next week, what DPO/weeks & days will you be?

@Jecca88 it sounds gorgeous I bet your lovely lakes in London are a bit warmer than our northern coast 😂😂😂
a trip to Athens sounds amazing it’s somewhere I’ve always wanted to go xxx

Yes, I think some are very lucky with the steroids while others aren't. With my two chemicals I have come to the conclusion that my body remembered how it wanted to behave towards an embryo and just set about attacking earlier. I agree re the MMC thing. That was my first and no idea how my immune system put an end to that one. The embryo was 6.2 and in fact when it was discovered at a scan six weeks later. It was just there. It hadnt reabsorbed or anything :(. Sonographer said she could see nothing wrong other than the fact that tiny person was no longer alive.

The research I read where they gave women with RPL low dose aspirin, progesterone, folate and prednisone showed really good results. The women had all been tested for various issues, including lupus, etc and the blind trial showed substantially better outcomes in the treated women than those given placebos. The report didnt say whether NK cells or high cytokine levels had been tested for so I have assumed not and I cant help wonder how many of the women participating would have been found to have high levels of either which the concoction helped.
I rather suspect you have read that report but if not, let me know and I will find the link.

You knowcwhenni had my MMC tge sonographer said "Dont worry, it wint happen again". As soon as I started my research I realised how wring she might be and made a mild complaint if I'm honest. I wrote to the department advising that this was not thr right thing to say to women in this situation!

@Hopeandfaith1990 - Will be thinking of you next week. Hoping everything goes really well for you x

Sorry, realised you have specified something fir my response - Thank you. Will report how the betas are going. Shoukd get a new number tomorrow or Sunday. I will be 5.6 at scan, if I get that far. Only got to exactly 5 weeks with the last two x

Thank you, you too. Crossing everything for you xx

You too hun x

Sorry @Hopeandfaith1990 we posted at the same time and I missed it 🤪. Wow isn’t it crazy how fast it all happens. Just keep doing what you’re doing xxx

The MMC thing is so interesting, now that so many of you are saying you've had them. When I saw the midwife for my second miscarriage, she also said that a miscarriage without pain and cramping is really rare and unlikely to happen a second time which gave me a bit of a false sense of security. The two miscarriages were so similar- 8 weeks, no heartbeat, I can't help but think there must be some sort of link with inflammation, blood flow etc. I also read that 8 weeks is when the placenta starts to take over and so there may be some sort of explanation there.

Hope everyone is doing well, I still have my fingers crossed for the two pregnancies @Gizmo1983 and@Objectiontime with hopefully lots more to come soon. Enjoy the weekend everyone xx

@Fletchasketch hhmmmm this is really interesting I’m nearly 42 so age doesn’t help. I was younger when I had the mcs I was 39 when I had my 1st loss
1st was a blighted ovum so told it was genetic that one I did bleed with this one
2nd was the 15 week loss a cystic hygroma was found week 10 it resolved but then I lost at 15 weeks on scan- had an autopsy and genetics checked as well as placenta all was normal
3rd ivf pgta tested a mosaic -16 these are known to self correct and mine did everything looked perfect. Dr edge told me she was genuinely shocked as everything looked so perfect- genetics were tested and all perfect
I only had the immune protocal on the last one, a few drs have said they think the 15 week loss was too late for natural killer cells but I will literally never know. Call it mothers instinct or not as I will never know but I always felt there was something wrong even after 12 weeks I wouldn’t let hubby tell anyone I was pregnant I just had this awful feeling something wasn’t right and when they said no heartbeat I just thought I knew it but your mind plays tricks doesn’t it, i honestly thought the ivf one would make it and she didnt so I was wrong with that one xxx
in about 50 years I bet they have all this solved and decoded they will know so much more xxx

Yes, I agree, there do seem to be a lot of us on the immune issue side who have had ar least 1 MMC. But worrying to be honest x hope you all have a good weekend too x

Yes, I think they are getting there with working it out. Lets hope it's in time for our generation to benefit x

Little update - With doubling time my hcg level should have reached 340 ish if tested this evening but I went last night instead and the level is 550 already. So happy currently. Trying to enjoy some good news while I can and praying things stay positive x

@Objectiontime that’s bloody fantastic news. Got arms legs and everything crossed. Xxx how are you feeling xxx

Amazing news @Objectiontime keeping everything crossed for you ❤️❤️

Hey, hope everyone’s well. So nice to read different people’s positive news!

As suspected my 10dpo negative tests were Infact negative - shocker 😆. Now CD4 and hoping maybe the hydroxy just needed more time to build up.

It’s been 12 months this month since we started trying for #2. I know not long in the grand scheme but 3 x MC later and every single one of my close friends pregnant it’s feeling a little harder each month.

Hubby has booked a sperm test this week ahead of me starting pred & progesterone again the following week. I’m also going to test BBT for the first time this month. Usually I just do digital ovulation tests but I’m thinking maybe they aren’t giving me the most accurate days

@Gizmo1983 and @Jecca88 Thank you both. No more bloods now p, just the start of the dreaded scans. Got first at 5.5 weeks,. They hope to see gestational sac and yolk. It all just seems a lot to expect that things will continue to go well x

@SWMum9 So sorry for your negative. It is a horribly difficult journey for some of us and just giving you a virtual hug x

@Gizmo1983 you've been through so much, you have so much strength to even be showing up and TTC after all of your experiences. I agree, I think the rate of research and discovery is very promising for the future - maybe even some of us too.

@Objectiontime that's so wonderful, I'm so happy for you. A great sign for sure. The scanxiety is so real, there's nothing that can really help although I always ask for a midwife to either do the scan or be present due to my history so it isn't just me and the sonographer. Its helped in the past.

@SWMum9 so sorry it wasn't your month. A year is a long time on this journey especially with the losses. I feel you with the pregnant friends, its so hard I haven't even seen one of my preggo best friends for a while because I just find it so hard. We talk all the time but I just find it hard in person. It sounds like you're doing all the right things with the hydroxy, sperm test etc and BBT so fingers crossed for this cycle.xxx

Morning ladies,

@SWMum9 im sorry about your negative this cycle and 12 months feels like so much time in this space.

@Objectiontime really hope the scan goes well, the HCG levels are really positive.

Hoping collection goes well this week @Hopeandfaith1990 how are you feeling on these IVF drugs?

Just had a BFN on day 10DPO. I just need some advice really - shall i have another go one more 'natural' cycle with the immune protocol or shall i just crack on with the IVF? i will need to have some more consultations and potentially start the stims in mid July? My thinking is - if i go with natural on immunes there is still a risk of another Genetic issue (My lastest miscarriage was Trisomy 21 - the only genetic issue out of my 6 miscarriages)

Hi @Jecca88 Thank you! I'm feeling okay thanks, bloated af atm but I'm on day 9 of them so that's to be expected. Had my final follicle scan this morning, and egg collection is confirmed for Weds morning. Something else to be anxious about now!! Lol.

Re your decision. I know we aren't in the same boat (I think I've been trying with no success for longer than you?) but I do wish I had started IVF sooner. Just because I've had such a positive experience with it so far (I know this isn't the case for everyone). If you are going to do PGT-A testing / any genetic testing then it could well be worth just cracking on. But someone like @Gizmo1983 will probs have a better oversight as someone who's done both.

IVF is a lot - but so is naturally TTC. If you feel fed up with TTC then perhaps its time. Equally, there's no harm in just giving it one more cycle if you don't quite feel ready yet, I think this is what I ended up doing. xx

@SWMum9 hey sweet I’m so sorry this whole thing just totally sucks doesn’t it. I tried doing BBT and failed miserably then I found my I watch actually monitors it mind you the months I got pregnant ( 2 years ago) I didn’t get the dip so make of it what you will 🤪🤪🤪.
@Hopeandfaith1990 woohoo got everything crossed for Wednesday I’m defo getting good vibes it’s going to be a good harvest 😂😂😂.
@Objectiontime have got everything crossed for that scan xxx
@Jecca88 hey sweet it’s a totally personal choice I’ll be honest I found going into IVF a wonderful break I know that sounds nuts but it meant no waiting for ovulation no ov tests in fact everything was pretty much out of my control I just had to do what I was told and as hope and faith will tell h u are busy scanning and injecting so you feel like you are doing something a lot you’re not bored waiting around. It’s a completely personal choice. We gave it a year after our last loss of trying but that was my husbands choice not mine I would have jumped straight in. Xxx
afm hmmmm well after having a week of being happy feeling pretty sickly and shitty I woke up this morning feeling pretty good I’m gutted. My boobs are still sore but that exhaustedness and grotty ness has disappeared in anyone else I’d say do t worry it’s just your hormones they fluctuate but this is my reality. I tried to find a scan today as I feel that different but there’s none and I have a scan with the dr on Thursday but I’m really not feeling very optimistic I just pray the symptoms come back xxx

@Gizmo1983 sending a hand hold. I know it won't change how you feel, but with my two losses I had no symptoms, except bizarrely around the point that the 2nd pregnancy had already ended, everyone told me it was completely normal for symptoms to be non-existent or to come and go. I am keeping everything crossed for you and hope that scan puts your mind at ease. x

@Fletchasketch thank you so much for this a hand hold is exactly what I need as everyone is like oh it will be fine when sometimes it just isn’t xxx