Immune /natural killer cell treatment when ttc or pregnant (aka the 17th pred thread!)

[Hula2]

This is a thread for those diagnosed with high or very high natural killer cells and trying to concieve or are pregnant and taking steroids/intralipids etc

Newcomers very welcome

Ps with regards to soerm Dna fragmention is important and we really wanted it done but we can't as dh doesn't have enough sperm to do it. It's an exp test but v good evdience it's relevant

Thanks Trying! Ugh I don't know what do :( Carry on with SO? Do ivf?

give SO a go I'm sure u will catch soon, u don't have any reason to do ivf really......in USA they do it for rpl coz they push pgd but i was told success is no better vs natural conception. not sure how thats possible though!
I'm doing ivf coz i have to...and yes i suppose for early losses it means ill have ivig/intralipids in me before i get preg and I'm hoping that helps....but then they say all the stimulation meds make ur uterus HOSTILE and ur immunes get messed up!!! WHO KNOWS! there is no rhyme nor reason. i still don't know how i got a bfp. I'm sure the urologist will think i had a faulty test and ask if i got a blood one done!

u and me are impatient and always changing things to hope it leads to success!

I've realised with this last bfp that when its meant to happen, and when its going to it just does and i can't do anything to control this part of my life. so I'm hoping to be a bit more laid back about it all.........partly coz the thought of having had 5mc make my heart literally sink and instead I'm going into detail and complete submission to ARGC

denial not detaial

Ah Trying you're right- I try so hard to be in control of this situation. In the end, I agree that when it's going to work it just does... But at the back of my mind I think if I can just find that one 'thing' that's causing everything, then it'll work next time :(

Your BFP is another example that shows fertility is so far from being fully understood. Giving yourself over to the ARGC and letting them do the thinking is a good way of decreasing stress.

Not giving up has got to count for something!!!

Came across this really well done research study on recurrent miscarriage that made me feel a lot better. Basically explained how even after a number of losses, the odds of having a live birth are still very good AND that it's important for women to know this so they can feel better about their situation.

After 4 losses, chances of overall eventual success are 76%.

After 5 losses, chances of overall eventual success are 73.3%.

fuiku.jp/report/data_21k/21k_07.pdf

Interesting

Except after 6 and 7 u fall off the edge and rates r much lower. To be fair in sure that's partly also coz people just stop trying because not everyone could take that many to be fair....(it's what I'll tell myself)

I read in another study that people do tend to give up after that and it contributes towards numbers dropping. Considering that, still having a 20% chance after 7 losses is much better than 0%. When older women do ivf there's odds of conceiving (not to mention miscarriage) are well below 10% yet seeing them succeed is not unusual.

On the bright side... Even after 6 losses you're more likely than not to have a live birth at some point!

Ugh advice needed! I've got a positive opk this morning and I've not done my trigger shot... Having my follicle scan today. Is it too late for a trigger now?

Hula or any other SO girls?

Hi Drttc
I'd wait for your scan. I think the positive opks can be 2 days before ovulation? It's good that your scan is today - maybe you won't need a trigger? I've always been a bit unsure why that's necessary?
Trying how are you doing? Have you had any advice on moving forward?

Oh I have no idea drttcc. Try pm hula and sunny hopefully they will get back to u? Or try Louise? But I think as u can surge for 2/3 day it might be ok. I usually surge for 2 days...

Billy as my tnf was 47!!! When I magically got my bfp I need to take my second round of humira. If it comes down I'm on the ivf rollercoaster end of Jan. If it's still high I'll need 2 rounds of intralipids with testing after each one to make sure it's below 30 before they let me cycle so means end of Feb for a start. I have a review appt in Jan so will go armed with a millions questions. Am doing ok, mainly in denial. It's hit dh like a tonne of lead bricks he's Talking about selling our home etc....anyways for now booked an amazing holiday over Xmas and new year! How r u doing? Have u see mr shehata since ur last loss?

Oh god that sounds complicated! Can you try naturally in the mean time? What do they say about you getting preg with high tnf? I'm sorry to hear dh is struggling. It's good that you've booked a holiday, you bloody deserve it!
I'm ok with this one some how! Think it's because we weren't really trying and I'd only known a few days. Not seen dr s but Louise says to just carry on as we were. Every time I wonder if there's something else we should have checked! This time I've been thinking bout hair analysis! But a big part of me feels so tired and tired of it all that I feel like I can't be bothered! Which sounds terrible!! Then I feel guilty!

Thanks ladies! I've emailed Louise... I had also emailed her yesterday to say it looked like I was going to surge today but got no response :( Don't know if this means I won't be able to trigger now... Which the entire point of my doing SO was to try to release more than one egg. So bloody upset. Why do I ovulate so early?!? This may be me written off for the year after once again spending hundreds of pounds trying to improve this cycle. Last week I almost changed my appointment to cycle day 9 (instead of 10) but decided to trust my gut and leave it. So much for my gut. Really upset now :(

Where'd you book your holiday for Trying?

I know wot u mean billy. Some days I just want to give in and stop! I've been eating so much shit this last week I really need to stop I'm sure I've put on like a stone!!

We can try but this bfp is literally not meant to have happened with dh sperm count. Tmrw I'm sure the urologist will think I'm lying to him! It's not medically possible but obviously as long as there is one sperm I suppose it is! So we will not try but we not using protection either...I'm clearly bloody fertile but for some reason can't keep them.

The tnf was only 33 pre humira and I don't know if it was my pregnancy which I didn't know about (it was rechecked the day before my bfp) or the humira which made it flare (as it can sometimes happen). Either way it's a bad environment for the embryo! So need to wait to do ivf until it's ready!

Drttcc sorry :( it's pants. Don't despair rem we said we can't control everything.

Well numbers are in... To follicles measuring at 19.5 and 19.7, and one piddly one at 10.5. Happy with that! Lining was called 'exemplary' for implantation which isn't the first time I've been told that... But then why haven't I ever implanted correctly?! Well conditions are perfect, will hopefully be told to trigger now, and then (as you reminded me Trying) it's out of ours hands. Well except for the shagging!

Oh god I'm knackered by all that worrying!

Meltdown/over.

Yeah great news drttc! I'm a bit thick, that means you can still use your trigger yes?

trying a lovely holiday is just what you deserve. Where are you off to? Is it possible your tnf flared because of the pregnancy and testing now would be more accurate?

hula big hugs, I respect your decision and I think your an amazing mother. Like trying I really hope you're one of those ladies who has their miracle baby. On a selfish note, don't abandon us here!

Third intralipids tomorrow. I still haven't told anyone, don't know what's wrong with me. Sometimes I just hide in the toilet at work and look at the scan photos. My sister in law is a week overdue as well.

Hey Snoopy! Actually Louise just explained to me that it's the average of the follicle size so they're both just under 18mm. So she said to trigger shot tomorrow! Even if one of my eggs ovulated before I trigger that the shot will set the second egg to release. Also said I had a really good response for such a low dosage. Gosh I was so stressed out!

Have you not told some family yet? How many weeks are you?

Oh wow drttc, I know I'm getting ahead of myself but in my head I'm imagining you with little non identical twins

Going by scan dates, I'm 15+3. I've told my mum, but I always tell her as soon as I get pregnant anyway.

Snoopy I can understand why you've kept it to yourself... It's going to be kind of funny when find out at you're already 6 months pregnant though Is there a date you have in mind or are you just not thinking about it?

It's great that you've responded well to a low dose. So I guess we'll be waiting for good news in about eleven twelve days?

I know I've sort of justified it in my head by saying I won't tell brother and sister in law because I don't want to steal their thunder. A friend emailed me at work today and in the middle of the conversation asked about 'the baby situation' so I just never replied. And I don't really know how to tell my colleagues, I've only known them for three weeks.

I keep putting it off, saying after the next appointment, after the next milestone but then they arrive and I just keep quiet.

Lol! That's the hope...!

Actually that's a good justification for the bro and sis in law I suppose... But once they hear how far long you are it'll be obvious you've not jumped the gun to steal the attention! No harm in keeping it to yourself until a little bit after their baby is born. As for your friend, reply when you're ready... I'm sure it'll feel really good!

Wouldn't worry about the work colleagues. I doubt they'll feel you owe them anything! I'm sure they'll be very pleased for you whenever they find out. In my department I never know someone's pregnant until they're properly waddling around and I whisper to someone 'Is... She?'. Always worried they may have just put on a few pounds!

Just seen your stress about the SO drttc!

I must admit I never used ovulation sticks at anytime but wouldn't suggest you use them with SO - the trigger shot timing is all to do with the size of your follicles. i generally always went for scan on day 10 and a few times I had one ready to pop, but like louise said the trigger will release the other(s). Also we continued to DTD a couple if dats before the scan and beyond the two days they tell you to do it just in case, and if I had one ready to pop then we would try to get an extra one in!

Looks like you had a good response though, I used to hate the scans - I was always worried how many I would have and how big they would be! Also the odds of twins etc us very low on letrazole!

Hey Dryttc - sorry you had a stressful day, if u ever need advice quickly then do try sending me a pm as i check my email quite often but usually only get on here in the eve if i m working. I ve had the same situation (tho my pos opk was the night b4 and i had already ovulated on the scan) but it sounds like you ve had a great response for the first cycle. The trigger is really for timing bd but without you would ovulate by yourself just less prescisely timed. They usually tell you to bd every day for the next two days after the trigger but if as you are already getting your own surge i would get to it straight away ! Also femara does tend to push ov earlier so i always tended to bk the scan on the earlier rather than late side. Fingers crossed you have a lovely bfp in 10 days.

Trying - how are you holding up ? I can understand how this time must be really hard on your dh as well. I think it can be a really diffuicult for them sometimes. Yay for a nice hol over xmas, sounds like just what you need.

Snoopy - glad to hear you are doing well, that must have been your last IL, are you off everything else now ? Tell people when you feel ready (or when you can no longer hide it, tho i did manage to smuggle myself 28wks pregnant with ds onto a ryanair flight by wearing a big hoody so i guess you ve got a few months yet !!).

Billy - how are you doing after your chemical ? What s the next step for you, are you ttc naturally and doing steroids, sorry can t remember.

Sunny - how s things with the GD, hope its not causing any issues.

Rosa - hope everything went well and you and bubs are fine.

Afm - weird not 'doing' anything, no drugs, no poas and no schedule for dh , gonna be hard to ignore ov signs when they come but gonna just try and keep busy (not hard at the the moment) and leave it to fate now......

Waves to everyone else.