RESPONSE Trial for Recurrent Miscarriage - Thread 4

[Vicki272]

Thread for all ladies on the RESPONSE trial - all stages welcome, for a bit of well needed silliness and good old fashioned all round advice and support!

vicki, poor love, you must be worried sick. Have you done a hpt since your bfp? It might just give you some clarity even though it's hard. Or the repeat bloods as kazz suggested would definitely give you a clearer idea. Big hugs and hand holding xxx

size, I'm sooo glad to hear that you made it through the class and that everyone was nice to you. I sometimes think acknowledging what's happened by telling other people is the only way to start to reconcile it with yourself. Sounds like you've had some pretty shitty reactions from friends but hopefully through forcing yourself to be with other pregnant people and talking about it you can start to feel more 'normal'. Definitely think speaking to your midwife about more support would be a good idea xx

Sorry you feel that way little, certainly wasn't meant that way. Like size said it's the information/advice you have been given which has been so different to what others have been told that has worried us all. Best of luck to you x x

Again little sorry you feel like that. It's the trial Drs we are getting at, not you. The injection is to be taken on its iwn, that is the whole point of the trial. Like size said earlier your blood results if successful will either show placebo, drug, placebo+aspirin, drug+aspirin.
The trial is to test the DRUG not to take it in conjunction with something else.
Like MAS said, why not take it with progesterone too etc (what I was on for 5 of my 8 losses).
Good luck, and I'm sure I talk for everyone when I say we wish you an easy and successful pregnancy. Take care.

Cross post. Sorry you feel that way little, it's hard to know what to do when the advise is conflicting. I wish you all the best in your pregnancy

Thank you for those lovely words Little. I'm really sorry to hear you ate going to leave the thread and if you do decide this is the best move for you I wish you and your little bean all the best for a very easy pregnancy.

I was also under the impression that Aspirin was not allowed and was actually questioned as to the last time I had taken aspirin (had to be at least six weeks before). I would definitely query it with your trial doctors. As for this invalidating the trial - one individual will not invalidatell the trial and as long as your trial nurse has it noted they can take into account when they analyse the trial data. They will have to do in depth analysis of all other Meds taken.

I truly don't think anyone is having a go at you, just concerned about cross information. You're priority has got to be you and the baby and if my doctor told me to do something I also would.

Oh gosh I've missed a lot :s

When I went on the trial they had to check I was allowed to take codeine as I have it for my ibs so I'm confused aspirin has been allowed. Sorry you felt like that little and reading from the start I don't think anyone meant it personally !

Mas yes I had my scan yesterday (sorry Vicki that's why L wasn't around as she came with me ) and we can add another boy on to our stats :)
Sorry if I've missed anyone and hope everyone is ok ! Nice to hear from you size :) and glad your antenatal class went well and it's lovely some other ladies came up to you at the end. Xx

I've also got a low placenta so in a way hoping it doesn't move so I can have my c section haha xx

Another boy!! Massive congrats Louise! Is it all real now??

Kazz I think they tell you not to take anything, even as a single individual, due to them having to sift through all the results. I wasn't allowed to take iron supplements because if I WAS on the the drug, they want to know ify iron was low BECAUSE of the drug if that makes sense? I wasn't allowed afterwards for the same reason and to see if my iron would go back up, which it did.
If there is a pattern in the data collected that shows iron is low, then obvs that's to do with the injection.

Still waiting to hear from RESPONSE. The website is now 'closed' as such due to them not taking on any more study patients so maybe they're not checking emails at the moment.

How's things this morning Vicki?

Morning ladies, ugh I'm really struggling last night and today. I feel so moody and it's like now I'm pregnant, I'm no longer me.
I hope I don't upset anyone by sounding ungrateful, a baby is all I've ever wanted but I didn't expect to feel this way.
It's like I'm just a pregnant person and that's all. I'm always tired and irritable, low in energy, achey, bickering with dh about nothing and then feeling guilty for complaining. I'm just scared I've lost me - and the way I feel now, I can't see an end to it. Is this how I'm always going to feel for the rest of my life? What if I never get 'me' back?
I know it sounds silly I just don't know where else to turn. My oh is being great but I find any excuse to snap at him since I'm a moany cow and he gets off Scott free, to me, nothing really has changed for him so I feel very alone. Hormones play a huge part in this I guess.
I started feeling buzzing/flutters weeks ago and then Sunday night I thought I felt kicks, although I can't be sure. Since then I've not felt anything any I'm worrying something's happened - I just feel generally yak about everything.
Sorry again if I sound ungrateful, I know I'm blessed to finally be at this stage.
Hope everyone is ok x

My advice Choccy is mainly to reassure Little that if she takes it and down the line it's discovered she shouldn't have that a song so the doctors know it will know destroy the entire integrity of the trial. Although I appreciate it is concerning that people seem to be following different procedures. More than anyone i would be devastated if the trial was invalidated as I'm absolutely sure I had the placebo and move wouldn't be in the position I am had I had the drug.

Kazz are you going to ask what you had when the results come out next year?

Philippa so sorry you're feeling down sweetheart, part of the hormones settling will make you feel like this.
Once you hit the end of second tri you'll start to feel 'yourself' again hopefully and start to flourish. The first part is shit, no denying it!!

I've been led to believe that we won't ever be able to find out..I've never known a medical trial where you could (My degree is Biological / Biomedical science which involved a trial as part of my final year).

With it being an American trial they may do things differently. if I could I'm not sure... it will depend where I am at that stage. Hopefully I'll be happily pregnant and well on the way. In which case I'd want to know. If I'm not though I'm not sure. To find out I'd had the drug and it failed would be yet another blow.

Choccy no it still doesn't feel real yet ! L was really happy I'd finally taken the step to buying maternity jeans haha ! I've started prenatal yoga and feel about silly going if I'm honest !
I'm getting really strong kicks now but still not sunk in ! I've bought one little blue dog and we can't bring ourselves to buy anything else yet.
Xx

We've been told we can find out once all the data has been analysed and published :)

Phillipaa sorry your feeling like that :( I've been really low at the moment and like u I'm snapping at DH for anything. ... Mainly for breathing haha x

Louise glad you're feeling a bit more at ease and yey on the jeans!!
Love preggo yoga, however our class went from like 6 women to over 20 an growing a few weeks back. They've now put people on a waiting list, including me as inwasnt there the one bloody week you had to put your name down for the following week.
I've emailed them as I wasn't very happy about it as I'd been there from 14 weeks pregnant!!
S
They're on hols at the mo and back first week sept so hoping I can get back in for the final few weeks.
did you get the dog in Next?? Love that one (even though I though it was a rabbit!!) well done on getting something, that is such a huge leap xx

No I got it from the hospital it's got rainbow ears so it's even more perfect :) might be stero typical but I like the whole rainbow baby theme :)
Oh there's a limit of 13 in my sessions and they do 3 a week which is good.
Xx

• stereotypical

Awwww Louise he's gorgeous!! Yes love the rainbow theme too. Seems so fitting doesn't it? We're having a jungle theme nursery but blankets etc I'm trying to get rainbow stripes (failing miserably though!!)

Choccy that's exactly what we like :)
I'm going to try and crochet my own rainbow blanket ! Just got to get the wool I like and start ( I'm not very fast as it's taken me a long time to finish pillow case)
Crafty crochet on Facebook does made to order blankets if your struggling and they are lovely ! My sister has one :) x

Louise congratulations! Lovely news. I love that little dog too, perfect.

I'm still too scared to buy anything. I have graduated to briefly looking in the shops but still can't make that step towards an actual purchase!!

Hi ladies... Wow I have missed a lot in the day I've been absent...

Congrats louise on the great scan and little boy! The dog is very cute.

little if you are still looking, sorry you are leaving! Would have been nice to have my buddy! Wish you the best with everything.

I'm still struggling the whole being pregnant thing (as in I don't even believe that I am) I have no symptoms really. L keeps telling me it's early days but I really just can't even wrap my head around it. Today I have decided I need to really make a conscious effort to not stress out.

Easier said than done... The spotting has stopped for now but can't relax about it. L checked with the docs yesterday after I rang and they said that they were worried it could be ectopic so have to keep an eye for any pain or change in blood but if it stays as it is then they are quite happy that its nothing. Just one more thing to add in to the mix of worries.

Still getting the twinges... Quite low down and they come and go. Anyone else had that?

Backache from the injection was bad on Monday but not too bad yesterday and yet to surface today.

choccy I've done hpts and they come back as positive quite quickly but it does little to put my mind at rest really.

How are you all? Sorry for the long moan... I feel like in the aim to get pregnant I hadn't really considered how stressful it might be. I feel like it's been an eternity yet my initial appointment was only last Thursday. Not even a week ago. Xx

Sorry in advance, I'm in a total tizz so this is quite a self obsessed post... I had my midwife appointment today and I went in all prepared to be honest about how anxious I've been feeling and that I've had a real dip in mood recently and that I've got this horrible feeling things are still going to go wrong. I haven't seen my midwife since 22 weeks (7 weeks ago) so it's fekt like forever. But when I went in it was a student midwife and my midwife was just hovering in the background. I wasn't even asked if I minded, but actually I REALLY did. But fekt too wobbley to complain.
Anyway, I did open up and explain how I'm feeling and got a bit teary and the student just palmed me off with some shot about taking things each day at a time blah blah. Oh really, that's new, I hadn't thought of that new way of thinking, what a breakthrough! And I was really disappointed that my real midwife didn't step in.
Anyway it got worse as I'm measuring big for my dates so I'm being sent for a scan, so now I'm even more flipping anxious. Something new to worry about - just what I needed! And the midwife didn't call me back about my scan time do I need to call the scan line number tomorrow so will Durand all night worrying that I eint get seen tomorrow and maybe not even on Friday. Also there was glucose in my wee, and I'm measuring big so I've got wirries about gestational diabetes. But I'm a size 10 and have a really healthy diet and have literally done EVERYTHING possible to have the best pregnancy outcome. I'm so exhausted with functioning on this level of anxiety and when j try to seek help another blooming worry is unveiled.
Waaaaah, honestly it's just gets tougher and tougher.
I want to be one of those eomen who don't know they're pregnant until they give birth on the loo.
Waving to everyone and sorry for being a big self obsessed cow at the mo. I'll read back the thread and see his you're all getting on once I manage to wind myself down a bit.