TTC or pregnancy on prednisolone or similar part 13

[VillageMum]

This is a positive thread for all those diagnosed with High or Very High NK Cells and looking to start TTC or already pregnant on Prednisolone and/or Intralipid treatment.

Newcomers very much welcome!

Hello all! Well finally after being on this journey for some time our little rainbow baby has arrived. Mia was born by c section on the 4th and is gorgeous. She is a little Jaundice but the midwife says it's nowt to worry about.
My emotions are all over the place, we never thought we would get here but here she lies next to me sound asleep as I type this post.
Love and light to you all and will keep you posted. Xxx

Tum a huge congratulations to you and DH!
What a lovely name! Enjoy!
Xx

Congratulations tum thrilled to hear that Mia arrived safely!

Congratulations Tum, always lovely to hear this news! (and )

Massive congratulations Tum on the birth of Mia. Gorgeous name, so happy for you.

Huge congratulations tum!!

Tum just adding my congratulations too. Enjoy every minute with Mia, and hope you manage to get some sleep and the odd half hour to yourself!

it's so good to hear postivie news on this thrread, it gives us all hope.

After my AF no show last month, it turned up as normal this month so have been taking my letrozole for my SO, got my scan with DR S tomorrow so will be interesting to see what he says. Hopefully I'll be stating the pred next week too, so there will be 3 of us on it for the first time!

Thanks very much all for your kind words I'm glad this is of some motivation to those on this same or similar journeys. I remember when I joined this thread and saw that some people had had babies owing to prednisolone and other treatments for immune issues etc and I remember thinking god that seems like an impossible dream to get to have baby of my own. But yeah I'm proof along with so many others on this thread that there is hope. And with the knowledge and experiences of all of the outstanding women on this thread this information can help others hopefully in getting you to where you wanna be.. anyway not sure of I'm making sense but thanks again for your lovely comments. X

Huge congratulations Tum x

Hi all

Congrats tum!!

Just wanted to update that the mc I had on Dr S treatment turned out to be trisomy 22. So basically it wasn't the treatment that failed. Will try to speak to dr s to figure out next steps ....

Triple so sorry for your mc but I hope you're reassured that there was a reason and it wasn't the treatment. Did you have erpc with mr s? I do wish I had now as the hospital couldn't get a result so always wondering..

Hi Mel

No I had it via my NHS hospital - quite pleased actually with the service and at least I saved some money by going private.

Surprised that they couldn't test as you had a hb initially so there was definitely a foetus there. I imagine in the case of blighted ovum it would be different. It's easier said than done but please don't worry yourself over this and focus on what will come up next. Are you starting on ivf soon?

Aw bless you, that's right sorry memory is hopeless.
Yes they tested but it didn't grow so couldn't get result, it happens apparently.
Yes hoping to go to serum feb probably x

Tum just logged on during our holiday to see if there is news for you. That's so brilliant, huge congratulations. I'm in tears after all you went through. Well done thread buddy. Oh and gorgeous name too.

Done my first SO round - had my scan last week with 2 follicles - and dr s happy! Did the hcg trigger shot last night and start the ores tomorrow morning - exciting and scary at the same time!!

I know SO often takes 4-6 goes but really hoping its quicker!! Interested to see what side effects I get with the pred too!

sunny good luck for this cycle!

Thanks, took my first pred today, not noticed anyhting odd yet so assume it may take a few days to buold up in my system before showing any side effects.

Had a bit of an ache today in my womb area so hoping that is ovulation - don't normally feel it but guess 2 eggs are coming out so thats why i am noticing it (I would love to have twins so keep crossing my fingers that both eggs are fertilised!!)

Ooh good luck sunny. I'm 10 dpo today so will be doing so again next cycle to use up meds x

Hello all, I have been on the RMC thread for a while, and the lovely baking has pointed me in this direction as I am considering NK cell testing...

I have had 4 losses in 2 years, the last 3 within a year. I have 1 gorgeous DS, aged 3.5

1. MMC 12 wks, embryo measured 7.5
2. TFMR at 13 wks after 12 WK scan revealed many problems (9mm NT, fluid on abdomen and lungs, very fast heart rate) given 90% chance of death in utero - found to be chromosomally normal.
3. Anembryonic - discovered at 8+ wks - found to be T22
4. HB seen at around 7 wks, but slow, and gone by around 8 wks - found to be chromosomally normal.

All my St. Mary's tests have come back normal.

I wonder if I could pick your brains?

I know the chromosomally normal part and death after HB is suggestive of possible NK cell issues. But does anyone know if my second loss, with survival until 13 weeks (don't know how much longer it would have survived) and the issues mentioned, could have been NK cell related?

Also I know people tend to go to Coventry or London, and am I right in saying only Coventry does the uterine biopsy / scratch for NK cells? And that London clinics tend to prescribe more 'aggressive' medications? (Or am I simplifying things too much) Can I ask why people chose Coventry or London? I live in London but am not sure which clinic I would feel most comfortable with. The thought of any medication in pregnancy terrifies me, but I am reading success stories on here (congrats tum!) and presume given a choice you would all rather not be on meds either, but sometimes has to be done.

Do people only find out they have high NK cells due to RMC?

Sorry for all the questions, and replies really appreciated.

Oh, and I'm aged 40

Hi Bootles
I'm no way at all an expert compared to the lovely ladies on here and I'm just in my second cycle of shehata plan.

I wasn't sure who to go to either and was changing my mind every day for about a month!

In the end I went with shehata - I got/have it in my head that I need steriods! Weather they treat nk cells or something we don't know there is too much anecdotal evidence on the Internet of women who go on pred and succeed (also many who don't have have to find other routes) but a lot do.

I didn't want to go to quenby and be told ur nk cells r normal and go back and try against not get tx.

I suppose I wanted some form
Of treatment and most who see shehata seem to get high nk diagnosis and get pred. Maybe as he tests peripheral blood while quenby does the uterine levels.

I'm a medic..and i feel quenby is prob more evidence based (more evidence that nk cells in uterus are what's imp not peripheral blood) and quenby has done trials which i have read/seen results of conferences. i still went with shehata who I'm not sure has published his results...but I may be wrong. He also does intralipds and ivig which quenby doesn't (I'm not sure what I think of these tx but I'm going with the intralipds anyways!) it's an area with minimal research and so I've used a lot of mumsnet and babycenter to help me decide who to go to.

It's a hard choice! I hope I went with the right one. Either way many sucess stories with both and other women who have gone a totally diff route. I'm going to work my way through each of them till I finally make it!

Hope that doesn't confuse u more. The other ladies will prob be more helpful!

Add message | Report | Message poster cornflakes30 Fri 19-Sep-14 17:25:49
Hi everyone I hope you don't mind if I join this thread. Iam in need of support and advice.
I'm 44 next week and have TTC for 5 years and have had 10 miscarriages.. I have an under active thyroid, blood clotting when pregnant, v high NK cells and now high TNF alpha.
All my miscarriages have been within the first 10 weeks.
I am at the end of my tether and don't know what to do I'm not getting any younger I have tried treatment of Steriods, fragmin, hydrocloxocloroquine, aspirin, I had intreplids on one pregnancy as well and now I have just don't two Humera injections only to get the results back as they are gone up and not down. My endocrinologist is concern about humera and the thyroid causing Hughes disease in the future..
I just don't know what to do. My husband says I should stop and not take the next two humera injections but to name that means giving up..
Has anyone got any experiences similar.
Thankyou

trying, thank you. I have a medical background, but am way out of my depth with this stuff. It's really helpful to hear your reasoning, and it's exactly the sort of thing that helps me decide - ultimately its probably not that one is better or worse, just that individual women have differing perspectives. I'm very reluctant to take pred (because I have convinced myself I dont need it!), so only want to if I really really think its necessary, and so that pushes me towards Coventry.

Good luck with your journey, very much hoping your next pregnancy is the sticky one.

cornflake I just posted you a reply on the RMC thread, but I didn't have anything useful to say in terms of meds I'm afraid (someone here will though, I'm sure)

Hopender and Iggy how are you? I'm also in Edinburgh. Just about to start first cycle. Very nervous and emotional. Does anyone get lucky first time ? Happy weekend everyone. Best of luck