TTC Super Ovulation part 3

[Arianrhod]

Hey ladies -

There are a few of us who are ttc after mc's, however there will be ladies out there who are also ttc for the first time or second or third without success. If anyone is on, considering or had success on a super ovulation programme then do join us. How long did it take ? Did you try IUI with it.. ? Did you have PCOS?

Kicking this off and hoping some of you will join....

part 1 here:
//www.mumsnet.com/Talk/conception/1385998-TTC-Super-Ovulation

Part 2 here:
www.mumsnet.com/Talk/conception/1475108-TTC-Super-Ovulation-part-2?pg=1

[Mel3062]

Pebbles that's great news! I hope I get offered that too.
Evil witch came today :( a mix of disappointment yet relief that its here and I can get on with gonal f. Going Harley st on the 12th never been there before.
Waves to all xx

[Pebbles73]

Ari I stopped taking the starflower but I was on cyclogest last month to combsy the spotting so maybe that gas made my lining thicker. I haven't footed for two months now so maybe the lining has been able to build up better. I trigger in the morning and 'sex' Friday & Saturday, prefer it when he says intercourse! [hblush]

I know what you mean lemon, if I thought I would be posting about when I was going to have sex I would have thought that was mad!! How are you feeling by the way?

Sorry about af Mel but at least you can get onto your next cycle.

Thanks for all your positive vibes ladies and wish everyone a lovely weekend.

[duggs1976]

Good news pebbles, good news! Were you on 7.5mg letrozole this time? I am this cycle - scan on Monday at Harley street...hello everyone

[Pebbles73]

Yes 7.5mg Duggs , hopefully will work well for you too. Good luck.

[duggs1976]

Ohh first time at 7.5mg pebbles?

[Arianrhod]

Did we ever get a list of where everyone is at with their SO cycles? Are there a few of us now on our fifth/sixth cycle? pebbles and duggs, you are, aren't you? And me, of course. I'm just curious, I like stats :) And duggs, crossing fingers for your scan on Monday, do let us know how you get on!

Waiting patiently for AF to show her face so I can get on with my sixth cycle; I made a mistake thinking it's due tomorrow, it's not due until Tuesday. Oddly this cycle my bbs aren't hurting at all, which they always do almost straight after ovulation, so I'm wondering if I did even ovulate this month? I got an LH surge, double lines on my CBFM monitor stick and 'peak' reading, but just getting that surge doesn't guarantee of course that you will ovulate. Usually I would feel it, but I have had gastroenteritis so wouldn't notice a few extra cramps or pains in that region! Or of course it could be that this is my first full month of not taking agnus castus in a very long time, and of course that boosts progesterone, so perhaps the lack of that boost is why. Who knows, I wish I did?!

[Mel3062]

Month 6 for me starting gonal f tonight ....

[Pebbles73]

Yes first time in this dose Duggs and Ari this is cycle 6!

It's all a bit of a mystery if you ask me Ari!

[duggs1976]

Yes cycle 6 for me too! Oh I wonder if I get as good reaction as you pebbles?

[brownstag]

I am on my 5th cycle of SO, but that's 3 on Clomid and 2 on Letrozole, and non-consecutive (over a year). I totally regret taking Clomid this month. I thought the DHEA would counteract the side effects of Clomid and would make me like a young person taking it, but sadly not. So no hope at all of anything happening this month.
Also, just an observation about surges which don't lead to ovulation. I have now been charting for 2 years and I've never had a surge that wasn't followed by a temperature shift (although some cycles had short luteal phases) so based on that I would say that it's extremely likely that you did ovulate. I've also noticed that since having my last SO with Mr S, I no longer feel ovulation. I always used to and on that last SO cycle, ovulation was extremely painful.
Good luck everyone with this cycle!

[Pebbles73]

Good luck for today Duggs hope you get a good result. Let us know.

Sorry to hear the chlomid didn't work for you Brownstag, funny you should mention ovulation pains as I had terrible stomach ache Saturday morning and afternoon which I assume was ovulation.

[Arianrhod]

Interesting brown, I've found the complete opposite - SO has had no effect on my ovulation pains at all, it's only this month since I stopped the agnus castus that I didn't feel anything. I await this next cycle of SO with interest :)

Do you know for definite that the Clomid hasn't had the right effect this month brown?

Best of luck duggs, let us know how you get on.

[Mel3062]

Aw good luck duggs x

[duggs1976]

Well just seen dr s at Harley st. CD11 and 3 follies - not sure if they are "good size" or not as I usually have fewer but larger. They were all 14mm so he said to trigger on Wednesday CD 13. 10mm lining so he said he was pleased. He talked to me about TNF alpha (awkward.com) as I've had with dr g but I managed to get around it with a few huffs and puffs at patients "trusting" him etc. oh well we will see. Just paid £40 something for my ovitrelle ahh can I pre order it somewhere less expensive? How is everyone else ? Any testers lurking?

[Mel3062]

Well that's good hun. How come ovitrelle isn't £20?! X

[lemonsherbet]

think it is the difference between NLC and Harley street

[Pebbles73]

Sounds good to me Duggs, I had two at 14, one at 21 and one at 18.i didn't know you could buy it at Harley St and had a nightmare finding it at a chemist last month!
If you don't mind me asking was your tnf alpha result ok?

[Mel3062]

Aw I was hoping to get a £20 one :( ill have to get it at central homecare with my gold dust gonal f ( have to inject myself for first time tonight argh!)
is the scan and consultation still £210 the same??
X

[duggs1976]

Yes I got it at local chemist wellbeck on Devonshire street near marleybone high street was expensive though! My TNF a result was 27.7 so upper end but as long as under 30 then is ok... Yes he is at Harley street Mondays which is more convenient for me.

[lemonsherbet]

I not sure you can buy it at Harley street. Never been to Harley street but I remember being told you can buy it at NLC but think you have to get it yourself at Harley Street.

[brownstag]

I initially bought it via Mr S, and he told me it was cheaper to order it in advance from this company they were using. Can't remember the name but it wasn't cheap, £35 maybe?
ari, I haven't ovulated yet on the Clomid so I can't say for sure it hasn't worked. I'm sure there's a veritable clutch of eggs ripening in there but I can't see any sperm being able to navigate the primordial sludge that is my CM.
Good luck with all those follies everyone!

[Havingkittens]

Hello, not been around on this thread for a while but just wanted to respond to the Ovitrelle question. It's £20 from NLC, but you need to check they have it in stock before you pick it up. It's also £20 from Central Homecare, where Mr S can send a prescription but they charge £14 for delivery to London, so it still works out cheaper than a lot of chemists, even with delivery. They do free delivery with a minimum spend (can't remember what it is though), which works out if you are on Gonal F - so good for you Mel, but otherwise you're stuck with the delivery cost.

Good luck with your 3 follies Duggs. 14mm sounds good. He says they need to be bigger than 12mm before he knows they will be viable.

Best of luck to you all. xx

[brownstag]

Having kittens, that must be the same one I had. I didn't realise it was the delivery that made it so expensive.
Mmm, I've just been reading about DQ-alpha matching. I've read the webpage several times and I understand the genetics of it now (I think). Has anyone had the K-562 target cell test? Now, I have already had one child by my husband. As I understand it, that doesn't necessarily mean we don't have matching DQa's? Is that right? Yet I also do have high natural killer cells. Is it possible to have alloimmune and autoimmune problems? Is Mr S interested in this aspect and does he test for it?

The following para I found of possible relevance to my own case, but I don't want to be going on a wild goose chase ... :

'Such NK cell activity will initially often be limited and accordingly TH-cytokine production will wax and wane (in between exposures), allowing .early implantation (albeit with a damaged embryo) to proceed and even proceed for a limited period of time, only to abort in the first trimester. Ultimately, over time following repeated and successive exposures to DQa-?matching? embryos, NK cell activation will become a permanent feature. Once this happens uterine NK cell activation (as measured by the K-562 target cell test) will exacerbate to the point that as soon as the embryo reaches the uterus implantation will be thwarted and the woman will be considered as being ?infertile? when in reality she is experiencing a very early, preclinical miscarriage.'

Sorry if you've already covered this somewhere. I'm a bit out of date.

[Arianrhod]

duggs follies sound good to me, know what you mean about the cost of Ovitrelle. As kittens mentions I get mine from Central Homecare at the same time as my gonal-f, which makes it £20, or from NLC if I go there for my scan.

brown Get yourself some pre-seed, for those primordial sludge days ;)

Well AF hasn't shown her head this morning and probably should have done, but I'm not holding my breath since post-mc anything could happen. Nope, I'm not testing since I don't believe in any way there could be surviving wrigglies after 4 days (I know it happens for some ladies, but I just don't believe it would happen for me!) plus even without steroids I feel in no way pregnant at all. AF is just ... well ... out on the town, I guess, flying around on her broomstick :)

/waves to everyone

[Arianrhod]

brown I've not had that specific test but absolutely yes it is possible to have both alloimmune and autoimmune problems - I have both. And yes you could have one child with your DH and still have DQa problems. My OH and I are 100% matched for DQa (we are both 0201,0303) and this means that any embryo has a 50% chance of being a direct match with me, meaning my body would kill it off as not being 'different' enough to me. But equally that means any embryo has a 50% chance of NOT being a match, and so (theoretically) would be ok.

To explain a little, if this doesn't make sense, since an embryo takes one marker from each parent, it could end up being one of the four following possibles:

0201,0201 (one from me, one from OH)
0303,0303 (ditto)
0201,0303 (exact match for me)
0303,0201 (ditto)

So in the first two cases the embryo would survive, since it is sufficiently different to me, but in the last two cases it would be destroyed.

Hope that helps, a little!