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Original poster

High risk screening - Normal NT but high hCG, Low PAPP-A

453 replies

SoozyWoozy · 15/01/2012 21:06

Hello everyone,
I'm new to this board, so apologies if I'm posting in the wrong place!

I'm 13w pregnant with my 4th baby (6th pregnancy, first two were ectopic & mc). My other pregnancies went without a hitch, other than the dreaded SPD.

With the other 3 I just had a Nuchal as screening, and all were very low risk. My hospital now does combined screening so this time I had bloods done as well. My scan was apparently OK and the Nuchal measurement was within normal range but my bloods made me high risk with a 1:78 chance of a baby with Downs / other Trisomies. My BhCG was double what it should be and my PAPP-A was half, apparently can be an indication of trisomies, but even with no chromosome problems this can lead to other problems in pregnancy such as IUGR, preeclampsia to mention just a couple!

I guess what I would like to know is this - has anyone been in a similar situation and come out the other side?! I have an amnio booked for 16w, but the waiting is driving me crazy and giving me too much time to think about the what ifs and if I am doing the right thing having the amnio at all!

Any words of wisdom would be gratefully received.

Suzy

OP posts:
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Msarg95 · 05/09/2025 08:08

@Travtev what was your outcome if you don’t mind me asking?

TillyDLN · 05/09/2025 14:16

Msarg95 · 05/09/2025 07:37

I had a call yesterday that my cubs screening gave me a 1 in 109 change of T21 making me high risk and I am beside myself with worry. I am 30 years old, fit and healthy with an overweight bmi as am very muscular and exercise a lot. I am 13 weeks and this is my first pregnancy and I think I just wasn’t expecting this call it’s shocked me a lot.

NT was 2.3mm
Papp A was 0.42
HCG was 1.98

All within normal range with my bloods just is what the midwife said and the high hcg and low Papp a is what’s put me in this risk. I had the NITP bloods yesterday and have to wait a whole week. I just can’t stop thinking about a high risk outcome and am just making myself sick with worry. My boyfriend is positive which is good but I just can’t believe I have to wait a whole week.

Edited

It is such a worrying time. No matter how many statistics you read or how many positive stories people tell you, until you get your result you will naturally worry. Hopefully some of the posts on here and hearing others stories may go some way at reassuring you, but it will never fully take away the worry

Msarg95 · 11/09/2025 21:06

Thank you @TillyDLN got the call today of my NIPT results to say all 3 trisomy’s low risk. Honestly the most anxious week ever we are so relieved I couldn’t relax until today.

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