To wonder if there will be any fall out from skinny jabs?

[TheLemonGuide]

Everyone I know is now suddenly very slim. Okay, im exaggerating slightly, but genuinely, most of my friends who were previously overweight are all now slim thanks to skinny jabs. I am delighted for them! It seems unbelievable to think that a jab can cure this obesity crisis, but I am so pleased my friends and a couple of family members are able to live a healthier life thanks to this.

My only slight concern is, is this something that is going to be too good to be true? Do you think there will be any long term repercussions, or are we right to just celebrate this medication as a cure for something that so many have been battling for so long?

So not concern about the medications themselves then, but concerns about misuse of prescription meds.

The massive usage globally has already revealed an unforseen side-effect in use for weightloss - NAION, which results in sudden and irreversible blindness.

That's a really interesting article thanks.

There is a correlation between having a very high BMI along with non-alcoholic fatty liver disease and osteoporosis, but for the vast majority of people it is linked with a low BMI.

Do you think we should stop people getting paracetamol in case an extremely small number of people don't really have headaches and are going to misuse the drug?

@icecreamflowers NAION is not a proven side effect of GLP1s. A possible correlation has been noted in some data sets. No one on any of the clinical trials ever has experienced NAION. It is and it remains a very very rare side effect of weight loss itself. The possible correlation showed that the very very tiny risk of NAION when losing weight became an ever so slightly less very very tiny risk. There needs to be a lot of work done before you could say it’s an actual side effect and happens at a higher rate for those losing weight on GLP1s compared to those losing weight without GLP1s.

I know people like to drop it into threads because it sounds terrifying and is likely to scare people who are taking GLP1s currently or who are thinking about it. It’s never mentioned with any actual stats or references explaining about the risk level.

Thinking about this honestly, I’m pondering which is worse, my prognosis when I was 20 stone or losing my sight.

@measuringtaep if you look at the risk factors for NAION a lot of them correlate with obesity. So high BP, high cholesterol, diabetes, sleep apnoea, and so on. So once you have lost the weight and those factors have improved then overall your individual risk for NAION is likely to be much lower.

That is because it is emerging observationally and being noted by opthalmologists. It is a recognised association according to this mob:

Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) - EyeWiki

or as reported here:

Risk of NAION Higher in Patients on GLP-1 Drugs for Diabetes or Weight Loss

Clinnical trials which are limited in both time and numbers can't always throw up all possibilities - that's why drugs pass their trials and are approved for market use and then mass usage reveals further upsides, alternate uses; and also further downsides - which is what this thread is attempting to discuss.

It is and it remains a very very rare side effect of weight loss itself.

I don't know where you get that from.

Apologies, that is an inaccurate statement, it is a very very rare condition, and incidences are very unlikely to occur regardless of whether you’re taking a GLP1 or not.

There is no definitive proof of causation, or that it’s not connected to confounding characteristics. It’s already very rare. It might, possibly, be shown to be ever so slightly less rare for some GLP1s. I’m sure that at some point there will be a more accurate picture of whether there’s actually a causal connection.

Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) - EyeWiki

"GLP-1 Receptor Agonists
A matched cohort study of 16827 patients suggested a relationship between semaglutide and NAIONs. Out of the 16,827 patient, 710 had type 2 diabetes mellitus and 979 were obese or overweight. Of those who had T2DM or were overweight, 194 and 361 were prescribed semaglutide respectively. In the T2DM group, 17 patients developed a NAION while taking semaglutide where as 6 developed an NAION in the non-GLP group. Within the overweight cohort, 20 NAIONs were observed in the semaglutide group compared to the 3 in the non-GLP1 group. The cumulative incidence of NAIONs within the T2DM and overweight group was 6.7% compared to 0.8% of the non-GLP1 group. [32] The AAO and NANOS released a joint statement, addressing the study and the potential link between GLP1s and NAIONS. They recommended that patients do not stop their semaglutide based on this study and to discuss with their PCP if GLP-1 agonists are right for them. [33]"

There are also the 100 cases of NAION in the USA who have lawsuits pending.

GLP-1 Lawsuit & NAION Vision Loss - New 2026 Case Updates

"Several peer-reviewed studies have confirmed an increased risk of NAION in patients taking GLP-1 drugs:

1. Harvard Medical School & Mass General Brigham Study (JAMA Ophthalmology, 2024)
2. 9% of diabetic patients taking semaglutide developed NAION, compared to 1.8% on other diabetes drugs (a 4-fold increased risk).
3. For overweight patients, the risk was greater than 7.6 times higher compared with other medications.
4. Danish Nationwide Study (2024)
5. Examined 424,152 Type 2 diabetes patients over five years.
6. Found a 2.19 times higher risk of developing NAION for patients prescribed weekly semaglutide (Ozempic, Wegovy).
7. JAMA Case Series Study (2025)
8. Identified seven cases of NAION linked to GLP-1 medications, with rapid progression to blindness in some cases."

Gosh it’s got even more desperate now. I’m not sure you understand how to quantify risk. A multiplier of a tiny percentage is still a tiny percentage.

Identified seven cases of NAION linked to GLP-1 medications, with rapid progression to blindness in some cases

Of 424k diabetic patients. The term linked and directly caused by have very different meanings.

Depends on bmi, tiny risk of naiod, even smaller risk of going blind from it.

I assume you have other health conditions, ie diabetes, sleep apnea, high blood pressure, which causes your concern,

so I’d correlate it against your risk of cancer, heart attack and stroke due to your weight. So for example you’ve a 17 percent higher chance of getting cancer and dying due to your obesity than if you’re a healthy weight. 60 percent higher chance of a heart attack. And a 65 percent higher chance of a stroke.

so you really need to do the risk assessment. Of course if you can lose the weight and keep it off without meds it’s better, but I’d have guessed if you could you’d already have done this?

also then correlate it with the improved health outcomes of the drugs, so for example improved cardio vascular, liver and kidney disease, reduced cancers etc, and then make your decision. Good luck.

Depends on bmi, tiny risk of naiod, even smaller risk of going blind from it.

I assume you have other health conditions, ie diabetes, sleep apnea, high blood pressure, which causes your concern,

so I’d correlate it against your risk of cancer, heart attack and stroke due to your weight. So for example you’ve a 17 percent higher chance of getting cancer and dying due to your obesity than if you’re a healthy weight. 60 percent higher chance of a heart attack. And a 65 percent higher chance of a stroke.

so you really need to do the risk assessment. Of course if you can lose the weight and keep it off without meds it’s better, but I’d have guessed if you could you’d already have done this?

also then correlate it with the improved health outcomes of the drugs, so for example improved cardio vascular, liver and kidney disease, reduced cancers etc, and then make your decision. Good luck.

My optician says the blindness correlation is bollocks..

Exactly.

The PP seems to be ignoring that the first condition linked is sleep apnea, which is often related to being obese. But let's just blame the WLIs instead of obesity!

Well I have a consultant appointment on Friday to decide if it’s time to start having regular injections into my eyes to address diabetic maculopathy as a result of years of undiagnosed and untreated diabetes damage, so I’ll take the minuscule risk if NAION rather than the almost certain blindness as a result of nerve and circulation damage from high blood sugar.

Changes in paracetamol has already changed. People used to take overdoses of paracetamol deliberately, so now you’re limited to small pack sizes, and only allowed to purchase a small total quantity. It’s greatly reduced the percentage of paracetamol overdose suicide attempts.

It’s exactly this. Who would they feel superior to then?

I bought a pack of 84 from the pharmacy last week. The limit appears only to apply to supermarkets. It’s pointless anyway because you can buy several packs from different outlets if you’re determined.

Because there's only one shop you can get paracetamol from and you can't just wander over to another shop and get another lot. 🤔

Nurofen kills 2000 people a year, correctly used. I am yet to see a thread of people concerning themselves over the risks of nurofen.

wonder why that is..

Um you can go to multiple shops ..

I didn’t say it eradicated paracetamol suicide attempts completely, and if someone is determined, they will find a way. However, it has reduced the number of attempts and accidental
overdoses by an estimated 40+ % .