To think it will be revealed WLI cause physical aging

[Tuliptana]

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

That isn't ridiculous and it isn't what you said that caused me to call it ridiculous.

I do, however, attend a gym where two of the instructors "before" pictures show that they have made the change, sustained it and also been able to turn that into a career.

I don't understand you making a huge point about how few recovered obese peple there are, because people are putting the weight back on even faster when they stop using GLPs than when they stop dieting.

Yes, and also of keeping it off. Which for some obese people is the bigger problem!

Perhaps you could clarify then.

Do you think that diet and exercise constitute a drug free alternative for most people and if so, do you understand that in the majority of cases this eventually fails so they'll become obese again?

I haven't ever said people are jealous. If you want them, you can get them, so it's not envy in that sense. My issue is that people seem to think fat people shouldn't use them as they should suffer for thinness.

Regaining weight if you return to your initial state is obvious, surely. And a reminder to all that they aren't a magic cure. If you take blood pressure medication and come off it and your blood pressure rockets, no one (sane) is surprised, are they? I know that I need the medication to suppress my overwhelming urge to eat. Without it, I will return to bingeing, which is what got me here.

It's not a substitute for healthy eating is it? If you don't eat healthily, you won't lose weight. You can't override the suppression, gorge on cake and then expect to lose weight. Perhaps that's where the misunderstanding comes from? I don't know.

Personally, I lost 7 stone in 2020/21 and developed an incredibly unhealthy relationship with food from being so afraid to eat anything if I couldn't know the exact calories. I regained all the weight (and more) over the following few years before starting WLI's in 2025. This time, I can eat until I'm full, I crave healthy foods and water and have no desire to eat junk. I don't have to spend all day obsessing over what I eat (or what I can't eat), so yes it's 'easy' in that sense, but that doesn't mean my diet isn't better.

Smokers and drug addicts could both overcome their addictions without medication, but you'll be hard pushed to find a Mumsnet thread on the dangers of varenicline or methodone.

As far as I’m concerned I’m taking a legitimately prescribed drug, from a legitimate medical practitioner, for its legitimate purpose. No different to any other drug. I’ve had no side effects since the first couple of weeks, I’m eating healthily and I look and feel fantastic. End of story.

Other people’s health is no-one else’s business. So no need to be concerned about me.

I’m sure others will feel the same.

@MyLuckyHelper there are some ongoing trials on reducing alcohol use using GPI drugs
As up thread I only took them for a few weeks and I didn't fancy booze at all. My cousin who is alcohol dependent said the same.

Lots of obese people drink too much (the image of skinny alcoholics is far and few between). Alcohol daily is in the British diet and women are targeted with 'cheeky gins' etc.
Surely that is another benefit for the individual and their wider health?

There are plenty of people who have changed from being obese to being a healthy weight and stayed there.

There aren't though. According to studies, 90 or some studies claim even up to 99% of people who have lost weight by non-drug assisted means will regain it.

I’m not sure who’s meant by i understand users of these medicines are desperate for them to be risk free for anyone to use but if you’re meaning users of WLI are desperate for them to be risk free for anyone to use then all I can say is that you’ve just proved how ridiculous your opinions are.

Fact - I couldn’t care less about anyone else’s use of WLI though I have enjoyed the company of a few women in one of the threads here.

Do I spend time thinking about people misusing them? Absolutely not. I’m too busy getting on with an enjoying my own life.

Do I care if people use them and become ill because they’ve misused them? Absolutely not and as far as I’m concerned they’re numpties who deserve all they get.

Do I spend my time thinking about the opinions of people like yourself? No. Not all. The only attention you get from me is the length of time it takes to read your posts or reply to them. You see, you just don’t have the power you think you have when it comes to influencing me as a WLI user, and you certainly can’t read my mind so I’m at a loss as to how you think you can say what you did.

Fact - you have no relevance in, or influence on in my life whatsoever.

Hear hear.

we must have cross posted.

Yeah me too I’m not going to be less enthusiastic, I love I’m healthy, I love my blood test results are all now healthy, I love I feel energetic and look great, I love I’m in a fit and toned body, anyone who wants me to curb thay enthusiasm, tough. My prescriber, my gp, and my family are all happy and comfortable. And I’m a grown up,

netter than slowly killing your self with wine and cake as I’m fairly sure some folks the walking worried on here are doing.

so no curbing of enthusiasm, I will continue to say how wonderful it is. Don’t like it, look away.

Like most things, if a drug will help in any way, health wise, then it’s probably worth taking. If it’s just being taken for vanity, the it’s probably not being taken for the right reasons.

But, again, we all make choices.

@Imdunfer I'll make a new reply, as your edit was quite substantial.

You said 'I don't understand you making a huge point about how few recovered obese peple there are, because people are putting the weight back on even faster when they stop using GLPs than when they stop dieting'.

People putting the weight back on when they stop taking WLIs is a different point to the fact that ongoing WLI use is the only thing that's been shown to keep formerly obese people at a healthy BMI. All other methods have failed on a population level. Your two instructors are a minute sample size and don't refute the evidence we have in much larger cohorts. Genuinely, have you done any research at all on this or did you just think two people you know was sufficient evidence of anything at all?

That said, the science in relation to those obese people who did use WLIs then stopped is less settled than the science in relation to those who lost weight through diet and exercise. We already know, cast iron, not remotely a matter of opinion that diet and exercise usually doesn't work in the long term when a person is already obese. Whereas the recent BMJ review that found users regained at a faster weight (and also that they were still lighter than dieters at the end of the period!) said more research needed to be done. Because most of the studies they reviewed were from older rather than newer generation WLI drugs.

So we don't actually know what the newer data will say yet. Maybe it'll give better long term outcomes than diet, I don't know. Seems pretty unlikely it'll work as well as long term WLIs though. Which are the most effective tool we have.

Why isn’t it thr right reason. Have you been fat? I can tell you it’s demoralising for most. It has a huge impact on mental health.

feeling guilty for eating, but wanting to eat, constant dieting and regaining, hiding your body in your clothing choices solely purchased to hide the rolls, feeling too hot in summer, your thighs chafing. Wanting it to be winter or autumn so you can hide behind thick clothes and tights, Not wanting to expose any skin.

Constant, daily discomfort for all those things. So if someone wants to lose the weight, for cosmetic or vanity reasons, and are eligible, I’m all for it. Just liking your appearance again, feeling confident, is a huge improvement to mental health.

and I’d thoroughly recommend them to any one eligible who may not have any weight related health issues but is uncomfortable with their appearance. For me. Thays not a wrong reason. It’s another good choice.

No drug is risk free. You always have to balance side effects against benefits. I can get painkillers delivered in my shopping order that I also have to use responsibly and in line with the guidance. A paracetamol overdose is lethal. Ibuprofen can wreck your stomach lining. Codeine is addictive. I'm always thoughtful about what medication I use and am not responsible for people who use them in ways that aren't recommended.

Based on the increasing evidence that glp1s reduce inflammation and decrease risks of a range of life limiting diseases beyond that of normal weight loss we may well all be microdosing in 20 years time. Or maybe despite every indication otherwise they'll have killed mr and I won't be around to hear 'I told you so'. I'll watch where the evidence takes me and listen to my body and prescriber.

These drugs have the potential to save more lives than any other I can think of except vaccines and antibiotics. They mean the people I love could be with me and healthy for longer. That's something to celebrate and just the thought of it makes me happy.

I never planned to stay on WLI forever. It has only ever been about getting off them (four weeks from now) and living every day for the rest of my life as someone for whom being a healthy weight has to be a priority. My life will be lived around prioritising my health and weight. I know I can’t live forever, but I’m certainly going to give living to a ripe old age a really good go. I’m 68 now, and the longer I’m on this earth, the longer I want to be on it with my beautiful children and grandchildren.

Am I bothered by the fact that most people who lose weight on any kind of diet regain it? No, not at all. In fact, I don’t even give it a thought. The only person who matters in my life when it comes to my health and weight is me, and there is absolutely no way I’m going to let other peoples weight gain scupper me.

The word vanity is incredibly moralistic isnt it.

As I said upthread, I took the pill for reducing my facial hair. Vanity in other words.

And someone who is overweight taking this medication is taking it for a medical reason, its not ok to be overweight no matter how people might try to spin it. If they think they look better after losing weight thats also great.

I’ve done loads for vanity, I dye my hair. I wear make up. Now I’m slim I chose clothes I like and feel I look good in. Vanity, otherwise I’d shave my head and walk about in a pair of old joggers.

vanity is a moralistic word, it is used to indicate a failing of some sort in the person, like you’re committing a sin, or self engrossed or self indulgent.

im staying on wli, primarily for health, physical, but also mental. Im confident in my appearance, I enjoy getting dressed in the morning, I enjoy picking clothes to wear, the injections helps me keep that, I know I won’t gain weight, I don’t have the daily struggle any more. My clothes today will fit me next month and next year, I don’t need to struggle for that to happen.

so if part of it is vanity, then sure call me guilty, am happy to put my hand up and own it. All day. Every day.

😱

The risks and benefits of WLIs will be the same regardless of why a person is taking them. One's feelings about fatness and gallstones don't actually make two shits of difference.

Just a quickie - my vulval Lichen Sclerosus has vanished since I’ve been on WLI and I no longer use my steroid cream to treat it. And I’m told by my specialist that if they didn’t know I have it, they wouldn’t know. So whilst I have no plans to use WLI for maintenance, if after a few months off Mounjaro my LS comes back I’ll certainly reconsider microdosing to see if it keeps my LS at bay.

Love this post!

That's actually a very good point. 😄

What a great point! Well said.

??? I merely shared my observation. Classy of you to suggest I need psychological intervention for sharing my opinion

I think maybe it’s more you think your sils skin has come away from her facial muscles following about a stone and a half loss, and think the same of others. It does feel like it’s not rooted in reality.

I don’t think it’s an insult, everyone needs help sometimes.