To think it will be revealed WLI cause physical aging

[Tuliptana]

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

A neutral observation rarely starts with "I don't mean to be harsh but..." and ends in "no offence when to be honest, the content is both harsh and offensive. Women are not there to be objects attractive to your eye. If your observation is correct and weight loss injections turn us into 'very strange looking' 'saggy' humans at least we're healthy strange looking saggy women.

And what 'help' is that commentary offering?

I have this said to me a few times by those so concerned 🙄

I really couldn’t give a fuck I am healthier and look far better my big moon puffy face certainly puffed out my lines now they show a bit more

Kelly Osbourne is grieving in the public eye she really doesn’t need false concern over how she now looks older

Incidentally (probably because I’ve been looking at this thread) the algorithm threw up a side profile picture of Kelly on stage at the Brits and she looks fine - very slim, yes, but fine. I’d love to go for a drink with her and Sharon, I bet they’d be a hoot and have fantastic stories to tell.

Im very happy to stand by what I said, and I think you would really benefit from reading the other replies to your post quoted above as others have also picked up on your observations.

Just to clarify, PrEP prevents HIV being contracted, however is not a barrier contraceptive.
I'm unsure what you mean by detriment to health overall or risks of taking it long term. HIV meds (including those in PrEP) are generally well tolerated nowadays and blood tests are done to monitor in case of an negative impact on the kidneys or liver. There are also new treatments being developed - the latest being a twice yearly injection to prevent HIV (also not a contraception)

It is a change of use.

Prior to a few years ago they were only prescribed for type 2 diabetes.

It is a change in use yes, but this doesn’t mean they don’t understand the full impacts on the human body for people without diabetes, since they started using glp’s in trials over 40 years ago.

I do wonder if people think the previous data said nothing and all the global health authorities went ah fuck it, let’s just approve it and hope for the best, fuck data and protocols, let’s just run with it lads.😂

I don’t understand why anyone would be even remotely concerned about total strangers looking old. Surely no one actually cares about what people they don’t know look like.

I lost 7 stone and have kept it off for a year but didn’t use wli, not because I am a martyr to non injectable weight loss but because wli weren’t really a thing back then. If they had been then I would have taken them, however I don’t feel any envy or anger at people taking them now and that they may have it ’easier’ than I did, I don’t care what they do.

I do know that at 50 and 9st 7 (5’5) my health has significantly improved for losing weight. I also look damn good and, even with a slightly saggier face, much younger.

The poster I was replying to said it was not a change of use.

She then went on to write: Do you know much about them?

While not being aware it was a change of use.

The end.

Right just trying to work out the relevance. As quite frankly there is none.

They arent a change of use, they do the same thing for the type 2 diabetic, who may or may not be fat, as they do for the non diabetic

They regulate blood sugars, they control hormones and they facilitate weight loss

My OH ha been on them for nearly 20 years, possibly around 17 I think it is, the nurses made clear from the outside, its to help manage his diabeties and to support weight loss.

A hayfever tablet manages symptoms of histamine reaction. The change of use in MH is that they lower anxiety and help sleep.

It's true that there is no long term data on the effects though. I suspect it's net positive but it's a risk. And there have been problems relating to kidney injury

She looks malnourished and sick, like pictures of people suffering with aids in the 90s

Are you talking about KO?

Its not weight loss, its surgery on her cheeks, in combination with the big lips.

There's twenty years of data.

there is 20 years of real life data. 15 years of trial data before that and ongoing trial data since then, trust me, all the world health regulators really say fuck it, we’ve no idea of the long term let’s just permit it anyway,

are people really this ignorant on how meds come to market and what’s required. Do they go to their docs and when the doc prescribes something do they say how many years of data do you have, 40, no I can’t have that, it’s not long term enough for me,

however the point remains, if the risk profile is too high for you, stand down, no one is asking you to take em.😂

Relevance to fucking what?

The National Kidney Foundation state "GLP-1 medications, known for helping with weight loss, offer surprising benefits for people with kidney disease". But what would they know? They probably want more clients https://www.kidney.org/news-stories/what-to-know-about-glp-1-medications-if-you-have-kidney-disease

They are a change of use, prescribed off-label, and it is a different dosage in a different patient population with different (or non-existant in some cases) risk profiles.

They are not off label. Here's the approval for use for weight loss https://www.gov.uk/government/publications/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know/glp-1-medicines-for-weight-loss-and-diabetes-what-you-need-to-know

Anything..

Huh? Are you Ill informed or did you make it up in your head, and again. You can’t genuinely think all the world health authorities approved this, and have no idea if the impact on the human body, the long term effects, that the data doesn’t cross over.

and again, you don’t need to take them, stand down, ain’t no one rushing at you with a syringe, you can calm down and going back to watching the telly and eating crisps, 😂

I am really unsure why you are so aggressively reacting to basic statements of facts - given you are one who only reads "the scientific papers", I would have thought you would have been all over the basics.

I’ll say it again. It’s a prescribed medication, prescribed by licensed medical professionals, for a medically approved purpose. Why does anyone have a problem with this? It’s no different to any other medication.