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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

To think it will be revealed WLI cause physical aging

830 replies

Tuliptana · 02/03/2026 07:14

Obviously the pictures of Kelly Osbourne are both sad and terrifying.

But a few women i know have also used this method for weight loss and their skin has lost elasticity. They look at least 10 years older. Is this side effect being under played?

OP posts:
Thread gallery
18
Midsommermadness · 04/03/2026 22:43

EatMoreChocolate44 · 02/03/2026 07:20

Any extreme weight loss will age your face, that's why so many celebrities get fillers and have that 'pillow' look. Ozempic face is a thing apparently. Personally I think as you get older people look better with a little bit of weight on but everyone is different.

Post menopausal women are supposed to have a little more weight on them to protect their bones, think weight training.

Midsommermadness · 04/03/2026 22:50

This reply has been deleted

This has been deleted by MNHQ for breaking our Talk Guidelines.

Couldn’t agree more

Katey83 · 04/03/2026 23:33

SilenceInside · 04/03/2026 17:56

@Katey83 can you say why people like me wouldn’t be objective about the long term risks of WLI? Can you say what the risks are that people like me might be minimising or ignoring or similar? Just to note, I have not at any point mentioned jealousy or any other motivation for why people like to think that looking awful after using WLI is inevitable or common, or something to be concerned about.

If you have a medical need and are taking it for that, then it is obviously going to benefit your health, and is a good thing. For me, it is the people taking it who do not have a medical need who are taking unwise risks. By that I mean: people who are not significantly overweight, people who lie to prescribers to access the drugs, people who buy them off the back market, people who take them and double-dose to lose more weight more quickly etc. I know several of these people and half of them look awful, the other half admittedly look thinner than before and not noticably aged/ill. But beyond looks, which really who cares, there are side effects of these meds (some serious, such as stomach paralysis, thyroid cancer, pancreatitis and kidney damage) that it is ridiculous imo to risk simply to lose a stone or two, if there is not a medical need. If you are better because you have medication that solves a health issue that is great. It is simply obvious to many of us that these drugs are being used way beyond that as a more general miracle weightloss cure, and they were not trailled for that and so are not clinically safe for it.

Katey83 · 04/03/2026 23:39

Notsosweetcaroline · 04/03/2026 18:54

I don’t think anyone is suggesting that, when the conversation was about Kelly the comments were th4 woman is no longer on wli, hasn’t been for some time and mentally is struggling so people should leave her alone.

the jealoosy is over other women, women they don’t even know and can’t see, being able to be slim in what is perceived in an effortless way. No one is really buying all this faux concern and the ageing thing is laughable.

'lots of people are using a prescription drug for purposes it wasn't tested for, and some of them look unwell. It's worrying' = 'I am jealous of the idea of other people being thin.' Can you not see how warped that is? I would align it with ED thinking, honestly 'everyone is jealous, no one is actually worried about my weight' is exactly what my anorexic sister used to say all the time.

PfizerFan · 04/03/2026 23:50

Tuliptana · 02/03/2026 07:48

Sorry but no if it starts a discussion and stops young women abusing weight loss medication that was never developed for them , then it might just save a few lives.

Its almost as if no one wamts to talk about the elephant in the room..

Source: trust me, Debs

Soontobesingles · 05/03/2026 00:02

@Passingthrough123 "There is overwhelming evidence that these drugs improve heart health, reduce cancer risk etc."

That evidence is only for those who are/were at increased risk because of being very overweight in the first place. There is no evidence at all it has these effects in the general population. If you are not seriously overweight and are taking the meds as a weight-loss quick fix, you are increasing your risk of cancer (because the drug has risks associated with it), not reducing it.

bittertwisted · 05/03/2026 02:00

I was just thinking the 2 favourite judgy threads of recent times are about WLI or tax dodging selfish degenerates who deserve to die in Dubai
no surprise OP is loving the comeuppance of Dubai residents on various other threads

Sartre · 05/03/2026 06:20

I think sudden weight loss past a certain age ages most people. Some people actually look younger and more attractive when they’re a little plumper. It’s always been this way, even before WLI. Also doesn’t help that lots of people don’t work out alongside the jabs so they lose muscle mass quickly and don’t look toned.

Notsosweetcaroline · 05/03/2026 06:22

Calliopespa · 04/03/2026 22:21

I think you are feeling "got at" by this discussion, and I don't think there is any need for you to.

It seems to me you had genuine obesity issues that it was sensible to act to remedy, and have done so in a way that has made you healthier, not less so.

I don't think those are the people that are targeted by the misgivings.

Genuinely i don’t, and am surprised you interpret it that way, I’d have thought enough comedic/sarcastic/explanatory to show otherwise. I am fascinated by it. These threads are constant, every week there is another one, and it’s a hamster wheel of the same comments, I honestly don’t get it.

dor example the poster who came on to say after loosing 20lbs her sil looked like her skin seperated from her muscles, now sure we all laughed and rolled our eyes, but what fascinates me is why. All I can’t think is she’s venting on line, throwing out insults about her, maybe it makes her feel better in that moment, but the reality is, her sil will still become slim, she will still be on the meds, and the poster still won’t be able to get their hands on them,

and I do think that’s mainly what’s behind these silly posts. Posters making bizzare comments about it aging you, I mean cmon, we all know it’s bullshit. So what’s the point, is it just they feel better for saying something negative, even though we all know it’s not true, because ultimately at the end of the day, they still aren’t going to get their hands on th4 drugs, and they aren’t going to stop anyone on them,

it just seems bizzare in the extreme.

CreamolaFoam26 · 05/03/2026 06:34

Laskey · 04/03/2026 21:52

I don’t wish to be harsh but everyone I know who have been on them look like they’ve been to hell and back. To me it looks worse than normal weight loss. I know there’s not evidence to suggest this but even bit SIL who is only 30 and only lost 20 or so pounds looks very strange. Her skin seems to have become extremely saggy. Almost like it’s separated from her muscle/fat. I know a few people have take it and genuinely think they ALL have aged well beyond what would be normal with non-WLI fat loss. Just my observation. No offence intended whatsoever

I think the problem lies with you. I think you’ve jaundiced yourself with regards to WLI, and it runs so deep that you can only see what you want to see.

It’s not healthy to be so obsessed with something that you are losing a grasp of reality, and you’d probably do well to step back from all things WLI for a while. Maybe even see someone, because you do seem to be obsessed with them to the point of not seeing clearly.

No offence intended. Just an observation based on your contribution to the thread.

JennyWrenSeven · 05/03/2026 06:40

My personal opinion regarding The Osbournes.

People keep stating about grief being the reason for the complete face change. Weight loss I could understand but not the face. The older sister looks similar too. As a pp mentioned, there’s this bucal (sp) fat removal which many stars have had, which looks like, with the extreme weight loss, might be the reason for such a dramatic difference in the faces of all of the Osbournes (except Jack).

Peony1985 · 05/03/2026 06:53

Soontobesingles · 05/03/2026 00:02

@Passingthrough123 "There is overwhelming evidence that these drugs improve heart health, reduce cancer risk etc."

That evidence is only for those who are/were at increased risk because of being very overweight in the first place. There is no evidence at all it has these effects in the general population. If you are not seriously overweight and are taking the meds as a weight-loss quick fix, you are increasing your risk of cancer (because the drug has risks associated with it), not reducing it.

Once you get to target weigh you can be on a maintenance dose. Those no evidence that these people have an elevated risk of cancer or anything else.
The long term effects of being a healthy weight outweigh the risks.

Binus · 05/03/2026 06:56

Katey83 · 04/03/2026 23:33

If you have a medical need and are taking it for that, then it is obviously going to benefit your health, and is a good thing. For me, it is the people taking it who do not have a medical need who are taking unwise risks. By that I mean: people who are not significantly overweight, people who lie to prescribers to access the drugs, people who buy them off the back market, people who take them and double-dose to lose more weight more quickly etc. I know several of these people and half of them look awful, the other half admittedly look thinner than before and not noticably aged/ill. But beyond looks, which really who cares, there are side effects of these meds (some serious, such as stomach paralysis, thyroid cancer, pancreatitis and kidney damage) that it is ridiculous imo to risk simply to lose a stone or two, if there is not a medical need. If you are better because you have medication that solves a health issue that is great. It is simply obvious to many of us that these drugs are being used way beyond that as a more general miracle weightloss cure, and they were not trailled for that and so are not clinically safe for it.

Edited

Two stone is the difference between an obese and normal BMI for many women. If you're white it's anyone below about 1.6 metres (WLI criteria is lower for other ethnic groups). That is a significant minority of women.

I would agree with the broad point you were making if it were clear you understand that actually, obesity sets in much lower than a lot of people think. The argument people make about a couple of stone comes up with worrying regularity on here.

Notsosweetcaroline · 05/03/2026 07:05

Sartre · 05/03/2026 06:20

I think sudden weight loss past a certain age ages most people. Some people actually look younger and more attractive when they’re a little plumper. It’s always been this way, even before WLI. Also doesn’t help that lots of people don’t work out alongside the jabs so they lose muscle mass quickly and don’t look toned.

Of course sudden weight loss ages people. Thay really only happens with illness though, very few people lose weight suddenly on weight loss injections. It’s generally up to 2 lbs a week, in a consistent manner, have a read of any thread on here or Reddit and you can see that. Sure a small amount of outliers go fast and hard at it and yes it will impact how they look, but for most it is not the case and it’s generally just illness that causes sudden weight loss.

feeling plump/chubby/fat people are more attractive is subjective, although you haven’t completed your sentence, of a little plumper than what?

Nellodee · 05/03/2026 07:07

I’ve just used an online age calculator with my before and after pic. It reckons I’m 44 in both of them and since I’m a year older than I was at the start and 53, I’m not going to worry too much about having aged myself with wli. We all age ourselves by being alive and should be grateful that we do, because the alternative is a lot worse!

Dancingspleen1 · 05/03/2026 07:11

DancingNotDrowning · 02/03/2026 07:54

There are millions of years of patient data for GLP-1s.

i don’t think you’ll be seeing this es court cases you appear to be gleefully anticipating

I know! Some people appear so desperate for it to rain on others parade. All this nonsense about looking older because a person has lost weight. Yes it can happen with rapid weight loss whatever the route but skin usually catches up and there's treatments that can help improve collagen etc.
Going into middle age carrying extra weight will not make someone look younger. Its not all about someone's face that ages a person. Fitness, energy and body composition is important as well. Anyway the important thing is long term health and being comfortable in your own skin. WLI can help significantly in those departments. This category of medication has been around for 20yrs - that's alot of data!

Ooihuko · 05/03/2026 07:17

SundayFundayz · 02/03/2026 07:26

That’s quite a leap.
No fat in gas stretching out the wrinkles = internal organ damage

That doesn't seem like a leap to me. Rapid change to body composition doesn't look healthy, I wonder if there are other implications that we don't yet understand. I would imagine it's a huge load on homeostasis which is wide reaching. Know one knows the long term impact of glp1

AmandaBrotzman · 05/03/2026 07:25

Ooihuko · 05/03/2026 07:17

That doesn't seem like a leap to me. Rapid change to body composition doesn't look healthy, I wonder if there are other implications that we don't yet understand. I would imagine it's a huge load on homeostasis which is wide reaching. Know one knows the long term impact of glp1

Edited

What do you mean by 'doesn't look healthy'? The rapid change you talk about is a reduction in body fat primarily. When you're reducing body fat from an obese BMI to a lower BMI that is automatically primarily a healthy change. How does it 'not look healthy' ?

GnomeDePlume · 05/03/2026 07:31

Binus · 05/03/2026 06:56

Two stone is the difference between an obese and normal BMI for many women. If you're white it's anyone below about 1.6 metres (WLI criteria is lower for other ethnic groups). That is a significant minority of women.

I would agree with the broad point you were making if it were clear you understand that actually, obesity sets in much lower than a lot of people think. The argument people make about a couple of stone comes up with worrying regularity on here.

I would agree with this. I'm 5'3". At 10 stone I would be at the top end of a healthy BMI, at 12 stone 2lbs I would be obese.

In fact I am 14 stone 12lbs, down from 22 stone across 15 months on mounjaro. I want to lose another 5 stone. I do look older because at 22 stone there wasnt room for wrinkles. I'm 59, I now look 59. But the important thing is that my diabetes is now under control, other blood tests are also significantly improved.

DontKillSteve · 05/03/2026 07:32

I lost 5 stone in my mid 50s. I look younger according to everyone around me. I have energy, all my low level aches and pains are gone. I’m lucky in that my skin has pinged back nicely, no wrinkles, collapse or folds. My hair thinned a little with the low calories but is now growing back. The trick is to not go below normal BMI. For an unfortunate, often celebrity few, this will trigger underlying eating disorders. For the majority of us, losing weight and achieving a normal BMI will be wonderful for our health and ultimately, longevity.

whattheysay · 05/03/2026 07:35

Sartre · 05/03/2026 06:20

I think sudden weight loss past a certain age ages most people. Some people actually look younger and more attractive when they’re a little plumper. It’s always been this way, even before WLI. Also doesn’t help that lots of people don’t work out alongside the jabs so they lose muscle mass quickly and don’t look toned.

A little plumper is not the same as being overweight or obese. Half a stone over a persons ideal weight may make them look a bit more filled out and their face younger but 2 stones overweight or 3 or more then no they don’t look younger. Youthfulness is also to do with how you move and walk. There’s nothing youthful about having to push yourself off the sofa or not being able to walk fluidly because your legs rub together, doesn’t matter how wrinkle free your face is.

Notsosweetcaroline · 05/03/2026 07:41

Ooihuko · 05/03/2026 07:17

That doesn't seem like a leap to me. Rapid change to body composition doesn't look healthy, I wonder if there are other implications that we don't yet understand. I would imagine it's a huge load on homeostasis which is wide reaching. Know one knows the long term impact of glp1

Edited

But who is losing rapidly? That’s a small proportion of people. Most lose up to 2lbs a week on a calorie controlled diet. Wli make it more achievable and consistent, for the overwhelming marjoty it is not rapid. I lost 6 and a half stone at an average of one and a half pounds a week.

when I read threads on here, or Reddit, it’s the same for nearly everyone. Sure a small number being silly about it, and sure they don’t look good, no one disputes that, for nearly everyone else on these injections weight loss in healthy. The reason people see big changes is its consistent weight loss. It enables you to keep going to hit goal, it’s not about rapid weight loss. And most people know this.

milkyuniverse · 05/03/2026 07:56

Notsosweetcaroline · 04/03/2026 06:33

I can’t really comment to the voracity of the article in allure magazine you posted. I can though direct people to the trials on the medication,

here is the ai over view, anyone interested in the fact it is anti ageing can google based on the back of this and look at the multiple articles now on line from scientific bodies.

or maybe go with the plastic surgeon article in allure magazine..l

You didn't even read it, did you! Without reading, you doubt the "veracity" of the personal experience and report of more than 15 top board-certified plastic surgeons and dermatologists... Nope, nothing to see here!

I agree it is a great tool for people who are seriously overweight, but many women who only "need" to lose a few kilos are using it, and I do think taking risks with their future (and current) health unnecessarily.

GnomeDePlume · 05/03/2026 07:56

I do think that a lot of the 'looking older' comes from the observer actually looking at their friend/relative/colleague for the first time in a while simply because they look different. We dont actually look at people closely all the time. We only do that when something changes. At that point we take in all the changes which will include that someone is now years older than the last time we really looked at them.

I have a family event coming up soon. The last family get together was a couple of weeks before I started on mounjaro. I'm now 7 stone lighter. I have no doubt that some of my family will be thinking 'Gosh, Gnome looks a lot older'. Some of them may wonder if I have been ill. Not because I objectively look unwell but because I do look so different.

Forestgreenblue · 05/03/2026 08:10

OMG the amount of people claiming that it’s faux concern over Kelly Osbourne and people not on WLI are just jealous 😂Absolutely BEHAVE and get over yourselves

Funnily enough, in my teens I had a serious eating disorder. I had indeed been overweight at the time. I became dreadfully thin and extremely underweight. I prioritised my looks and ‘thinness’ over absolutely everything. My health both medically and mentally suffered massively. At one point I was that ill the GP thought I had leukaemia. I can confirm that being as thin as Kelly Osbourne isn’t fun or an achievement at all. In fact, it’s even painful lying in bed when your bones quite literally press against your mattress. I ignored it all - I simply wanted to be thin. Which is I imagine what Kelly Osbourne aimed for

Whilst many people don’t have side effects on the WLI, many people do. Both medically and mentally and these people will solely prioritise thinness over their health. As many others have said, they have experience of this through friends and relatives who don’t look healthy at all and have taken them just to be thin

It took literally YEARS until I would eat a ‘normal’ meal again. I was force fed by my mother at one point which was frankly traumatising. The thought of even gaining a lb made me terribly worried. At most I was eating half a weetabix mixed with water daily. So where people have referred to long term mental health aspects of the WLI where they are simply not eating as a result of the side effects of the WLI, and just focusing solely on weight loss and their cosmetic ideal, this is a great degree of what they are referring to.

For those who are happy on it and no side effects - well good for you and genuinely im happy for you - but note that not everyone is in the same boat as you.