Meet the Other Phone. Only the apps you allow.

Meet the Other Phone.
Only the apps you allow.

Buy now

Please or to access all these features

AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

to feel uneasy about what this means long term rather than surprised by the weight regain itself?

682 replies

HazelMember · 28/01/2026 18:03

I’ve just read a BBC article about research into weight loss injections like Ozempic and Wegovy showing that people who stop taking them tend to regain weight quite quickly.

I’m not shocked that weight comes back. That happens after most weight loss attempts whether they involve medication or not.

These drugs are increasingly talked about as something people might take for years or even indefinitely. That raises questions for me about what happens when someone cannot afford them anymore, when supply changes, when side effects become an issue or when a person simply does not want to stay on a medication for life.

If stopping leads not just to regain but to a fairly rapid rebound, it feels less like a temporary aid and more like something that is very hard to step away from once started. That sits oddly with how casually they are sometimes discussed.

AIBU to think the real issue here is not that people regain weight after stopping, but whether we are quietly normalising a treatment that may be difficult to discontinue once begun? Or is this simply the reality of managing a chronic condition?

A woman, wearing bright red nail polish and unbuttoned blue jeans, injects herself into the skin and soft tissue of her lower abdomen with an obesity jab pen.

People coming off weight-loss injections risk fast weight gain

Overweight people shed large amounts on jabs but gain 0.8 kg a month on average once off them, study shows.

https://www.bbc.co.uk/news/articles/c050ljnrv2qo

OP posts:
Thread gallery
14
Perimenoanti · 28/01/2026 21:45

Whataninterestinglookingpotato · 28/01/2026 21:37

How did you come to the conclusion that using weight loss injections as a tool to loose weight and start the lifestyle changes was against my narrative? You really are reading too much into things and getting unnecessarily offended.

my point is that people may need support to keep up enough lifestyle changes to maintain weight loss after the jabs. Because surely changing your lifestyle and coming off them is preferable to long term meds with uncertain side affects. But you don’t seem to want that.

One last time for you: for some that's not possible. Its better to stay on medication and accept the risks as the risks of obesity are far greater.

The side effects are not uncertain. You must have been reading the daily mail. The medication has been around for 20+ years.

There really isn't much depth to anything you say. Its all quite superficial. As soon someone challenges you you backtrack 'I didn't say this, what i meant is, you read something into it, you get emotional'. I tend to disengage with people showing this pattern and that's what im going to do.

EmeraldShamrock000 · 28/01/2026 21:46

Within the next year there’ll be cheaper maintenance pill brought out. It is a booming business and will eventually be tailored to suit all needs and pockets.

soupyspoon · 28/01/2026 21:46

Perimenoanti · 28/01/2026 21:45

One last time for you: for some that's not possible. Its better to stay on medication and accept the risks as the risks of obesity are far greater.

The side effects are not uncertain. You must have been reading the daily mail. The medication has been around for 20+ years.

There really isn't much depth to anything you say. Its all quite superficial. As soon someone challenges you you backtrack 'I didn't say this, what i meant is, you read something into it, you get emotional'. I tend to disengage with people showing this pattern and that's what im going to do.

Gaslighting innit

These threads are all the same.

Perimenoanti · 28/01/2026 21:46

DarkForces · 28/01/2026 21:44

I've tried that. I know what to do. The medication enables me to put my knowledge into practice. I can't do this when my body is fighting me constantly as it pretends it's starving and messes with my blood sugar levels and hormones. The medication stabilises this. It's not like normal hunger. I'm fine with that and keep my dose low so I still experience hunger. It's very very different off the injections. I don't need therapy or advice. I need a prescribed medicine to enable me to stay healthy. If you haven't experienced it lucky you, but the idea of being lectured by people who can't understand what it's like is more likely to send me to a pile of cream cakes than actually help.

But WILLPOWER

Perimenoanti · 28/01/2026 21:48

soupyspoon · 28/01/2026 21:46

Gaslighting innit

These threads are all the same.

Yes its abusive. Plot twist: i have seen a therapist for 4 years and remained obese 😂

AbbaDabbaDooh · 28/01/2026 21:51

I'm hoping it changes the food available in shops, but also worried that it becomes a lot more expensive because people are eating less.

I'm also concerned about loss of muscle mass from sudden weight loss. It is catastrophic in older age.

I think we conceptualise the problem wrong- we are not obese, we are under muscled. My cholesterol improved a lot when I was lifting weights.

BatchCookBabe · 28/01/2026 21:51

I'm not being funny @HazelMember but I really can't see the point of this thread. Why have you posted it? Just so you can gloat about how people who spends 1000s of pounds on weight loss injections and lose say, 7 stone, will regain it all all as soon as they come off the jabs? Ha ha ha. Hmm

Seriously, what is the object of this thread?

BatchCookBabe · 28/01/2026 21:52

Perimenoanti · 28/01/2026 21:46

But WILLPOWER

Eat less, move more, duh! 🙄

Perimenoanti · 28/01/2026 21:53

BatchCookBabe · 28/01/2026 21:51

I'm not being funny @HazelMember but I really can't see the point of this thread. Why have you posted it? Just so you can gloat about how people who spends 1000s of pounds on weight loss injections and lose say, 7 stone, will regain it all all as soon as they come off the jabs? Ha ha ha. Hmm

Seriously, what is the object of this thread?

Claims to want to have a discussion. Posting articles from the BBC but doesn't actually want to hear from WLI users.

Duckishness · 28/01/2026 21:54

HazelMember · 28/01/2026 20:24

Of course. but as the article said:

People who come off slimming jabs regain weight four times faster than dieters

How is this surprising. Seems like psychology and physiology 101.

Non-WLI route requires self drive to fundamentally change behaviour over a sustained period of time.

WLI induces a physiological response rather than a behavioural one. I am not saying there’s no behaviour shift at all, I’m sure there is, but the barrier to inject is far, far lower. My sister takes them as she just can’t manage on her own the ‘traditional’ method due to genetics and environmental reasons.

Take the injections away and unless the fundamental behaviours have changed, and the fact muscle burns calories and might have been reduced with WLI, it’s so not surprising to me.

Guess what happens to people who stop blood pressure drugs who have an underlying diet and exercise cause….

BatchCookBabe · 28/01/2026 21:54

Perimenoanti · 28/01/2026 21:53

Claims to want to have a discussion. Posting articles from the BBC but doesn't actually want to hear from WLI users.

Yeah exactly. The faux concern is nauseating and tedious.

soupyspoon · 28/01/2026 21:59

BatchCookBabe · 28/01/2026 21:52

Eat less, move more, duh! 🙄

Hold on, are you sure? I thought it was the other way round. How come no one told me.

Citrusbergamia · 28/01/2026 22:01

blubberball · 28/01/2026 18:08

I'd love to be on wli. The cost and side effects put me off

Same for me.

My SIL has used WLI for the last 9 months, she's lost 3.5 stone. But she is having to stop because of severe hair loss but also because she can't afford it anymore. I feel so sorry for her because she finally found something that works for her BUT she openly admits that she's not been eating particularly healthily (just less of her usual foods) and has not incorporated any form of exercise in the last 9 months. 😬

She knows the weight will pile back on and she's so unhappy 🙁

BatchCookBabe · 28/01/2026 22:02

soupyspoon · 28/01/2026 21:59

Hold on, are you sure? I thought it was the other way round. How come no one told me.

😆 LOLOLOLOL!!!

Don't the silly billy weight loss injection people know this?

It's sooooooooooooooooooo easy!

Just eat less. Move more.

Arf arf. 😆

AltitudeCheck · 28/01/2026 22:03

I also think WLI have changed the way people in the UK feel about obtaining medication privately. I know pre WLI a handful of people will have bought (legitimate) prescription only medication from private providers and online. WLI has really brought this this into the mainstream. Can't help feel it's having the unintended social side effect of preparing us to accept paying directly for healthcare and accepting the slow fade of the NHS.

BatchCookBabe · 28/01/2026 22:03

Sorry, I shouldn't joke/take the piss, I know how tedious it is, when people make out it's sooooooo easy to just lose weight. If only eh?!

Bloozie · 28/01/2026 22:03

Whataninterestinglookingpotato · 28/01/2026 21:33

A quick Google search will tell you that less than 5% of all obese people are obese primarily because of medical conditions.

https://pubmed.ncbi.nlm.nih.gov/33899337/

https://www.sciencedirect.com/science/article/pii/S147021182404572X

Reducing such a complex issue down to 'eat less, move more' and 'learn to cook', and the other bullshit on this thread, is pure ignorance.

People on WLI know they are likely to regain weight after. They know this because it's a pattern we've experienced our whole fucking lives. I have lost weight the willpower way, I've lost weight the cabbage diet way, I've lost weight the personal trainer twice a week, swim a mile 3 times a week, run 5k twice a week and keto diet way. I've done intermittent fasting. The weight comes back. I eat exactly the same as my husband and move more. He is not obese. I am.

All the moralising on this thread, like fat people just have no idea how to lose weight is a pure waste of your time.

We know. We know better than you. No one knows more about the calore content of an apple vs a biscuit, a spoon of hummus vs mayo, what adding baked beans on your cheese does to the glycaemic index of your lunchtime jacket potato, than a fat person.

Believe me, we know.

We also, therefore, know that it will be difficult coming off mounjaro or whichever GLP-1 receptor we're on.

But thanks for the concern, guys. It feels SUPER sincere. No, really.

Genetics of Obesity: What We Have Learned Over Decades of Research - PubMed

There is a genetic component to human obesity that accounts for 40% to 50% of the variability in body weight status but that is lower among normal weight individuals (about 30%) and substantially higher in the subpopulation of individuals with obesity...

https://pubmed.ncbi.nlm.nih.gov/33899337/

Crwysmam · 28/01/2026 22:05

Perimenoanti · 28/01/2026 21:13

I also think the quite valid comparison shocked you and you probably didn't see another way but to insult obese people for not trying hard enough according to your belief.

Sorry it’s not. As a cancer survivor that offends me. If losing weight could have cured my cancer, treatment would have been infinitely easier.

With the threat of recurrence I have had no problem motivating myself to follow a calorie deficit diet to lose 2stone in order to reduce my risk. Changing my eating habits was a damn site easier than the treatment I had to undergo to remove the cancer from my body.

Duckishness · 28/01/2026 22:10

Bloozie · 28/01/2026 22:03

https://pubmed.ncbi.nlm.nih.gov/33899337/

https://www.sciencedirect.com/science/article/pii/S147021182404572X

Reducing such a complex issue down to 'eat less, move more' and 'learn to cook', and the other bullshit on this thread, is pure ignorance.

People on WLI know they are likely to regain weight after. They know this because it's a pattern we've experienced our whole fucking lives. I have lost weight the willpower way, I've lost weight the cabbage diet way, I've lost weight the personal trainer twice a week, swim a mile 3 times a week, run 5k twice a week and keto diet way. I've done intermittent fasting. The weight comes back. I eat exactly the same as my husband and move more. He is not obese. I am.

All the moralising on this thread, like fat people just have no idea how to lose weight is a pure waste of your time.

We know. We know better than you. No one knows more about the calore content of an apple vs a biscuit, a spoon of hummus vs mayo, what adding baked beans on your cheese does to the glycaemic index of your lunchtime jacket potato, than a fat person.

Believe me, we know.

We also, therefore, know that it will be difficult coming off mounjaro or whichever GLP-1 receptor we're on.

But thanks for the concern, guys. It feels SUPER sincere. No, really.

Edited

This and I don’t even take WLI.

There are genetics traits. It is also a globally observed trend. Add in lifestyle of work these days and the food manufacturing industry and of course people struggle!

There are genetic traits for neurodiversity. I don’t see anyone suggesting people stop that medication or saying if you could just try a bit harder to not stim or have a meltdown, I think if you just practice deep breaths it would be fine.

Perimenoanti · 28/01/2026 22:11

Crwysmam · 28/01/2026 22:05

Sorry it’s not. As a cancer survivor that offends me. If losing weight could have cured my cancer, treatment would have been infinitely easier.

With the threat of recurrence I have had no problem motivating myself to follow a calorie deficit diet to lose 2stone in order to reduce my risk. Changing my eating habits was a damn site easier than the treatment I had to undergo to remove the cancer from my body.

Im really sorry you went through this. My point though was that cancer and obesity are top causes of death. One is accepted to be nobody's fault and the other is just a lack of willpower and laziness. Im actually offended that you bring it down to willpower too.

If i had only two stone to lose it would be a walk in the park. I have done this myself over the course of my life. 2 stone eh.

PotteryChuck · 28/01/2026 22:16

I lost 6 stone 15 years ago by changing my diet and lifestyle, I never regained it. I eat a varied wholefood diet with limited junk and enjoy exercising every day.

If WLI's were available back then I'd have definitely used them to help me lose the weight.

Moonandstarsandsun · 28/01/2026 22:26

I lost 2 stone over 3 months with them back in July. Not put any weight back on. Most I do put on is 2llb but usually gone the next day, depends on if I’ve eaten bread.

Crwysmam · 28/01/2026 22:36

Perimenoanti · 28/01/2026 22:11

Im really sorry you went through this. My point though was that cancer and obesity are top causes of death. One is accepted to be nobody's fault and the other is just a lack of willpower and laziness. Im actually offended that you bring it down to willpower too.

If i had only two stone to lose it would be a walk in the park. I have done this myself over the course of my life. 2 stone eh.

I still have another two stone to lose so please don’t mock. Unless you have faced a genuine death sentence you have no idea how different it is to obesity. I was happy to waddle around 4 stone overweight, I didn’t feel the need to reduce my risk because obesity didn’t feel like a life sentence. Once diagnosed with cancer and, although reassured that they could probably treat it, they also said that there was no guarantee.

What really changed my mindset was watching my DSis die within a few weeks of being diagnosed with pancreatic cancer. It’s incredibly motivating. And everytime I stand in front of the fridge or am tempted to over indulge I just think back to the weeks we spent with my DSis. That experience will never leave me. She was younger than me so it felt so wrong. It was different watching my DM die b cause I was so much younger and had the confidence of youth. I felt I had time to fix things and at that stage I had a had a healthy BMI. But as the weight crept on the risk became more real. My DSis was always the healthy living, active non drinker in the family. The one with the least risk. So it somehow feels wrong that she didn’t survive and scares the shit out of me, so I’m no longer as relaxed about my weight.

Perimenoanti · 28/01/2026 22:48

Crwysmam · 28/01/2026 22:36

I still have another two stone to lose so please don’t mock. Unless you have faced a genuine death sentence you have no idea how different it is to obesity. I was happy to waddle around 4 stone overweight, I didn’t feel the need to reduce my risk because obesity didn’t feel like a life sentence. Once diagnosed with cancer and, although reassured that they could probably treat it, they also said that there was no guarantee.

What really changed my mindset was watching my DSis die within a few weeks of being diagnosed with pancreatic cancer. It’s incredibly motivating. And everytime I stand in front of the fridge or am tempted to over indulge I just think back to the weeks we spent with my DSis. That experience will never leave me. She was younger than me so it felt so wrong. It was different watching my DM die b cause I was so much younger and had the confidence of youth. I felt I had time to fix things and at that stage I had a had a healthy BMI. But as the weight crept on the risk became more real. My DSis was always the healthy living, active non drinker in the family. The one with the least risk. So it somehow feels wrong that she didn’t survive and scares the shit out of me, so I’m no longer as relaxed about my weight.

Edited

Ah so you actually have lost some weight but not all of it and its not actually clear whether or not you will be able to keep it off. I wish you that you will manage just like any other obese person.

Again, you assume that your experience of obesity would be anyone's. Im not even going to comment on the death sentence part. From my perspective you were lucky to have had a good chunk of your life without facing the possibility of dying.

Chumpfriend · 28/01/2026 22:58

I was on WLI and lost 2 stone. I’m only down to 13.5 but I was much bigger. Been off them almost a year and not really had a huge struggle - eating more but maintaining. Haven’t had to totally rethink my life choices as others have suggested.

Going to go back on to lose another 1 stone maybe and then will come off again. I have friends on them who have gone all in and lost loads. I’m happy at this weight - size 16 - but will also be happy at a size 14. It’s like anything - do what works for you and don’t listen to the hysteria around it.

Ozempic made me depressed so switched to Mounjaro and was pretty straightforward. To this day, no one in my life knows I was on them. I love listening to the convos whilst remaining non-comittal. 😂

Swipe left for the next trending thread