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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

to feel uneasy about what this means long term rather than surprised by the weight regain itself?

682 replies

HazelMember · 28/01/2026 18:03

I’ve just read a BBC article about research into weight loss injections like Ozempic and Wegovy showing that people who stop taking them tend to regain weight quite quickly.

I’m not shocked that weight comes back. That happens after most weight loss attempts whether they involve medication or not.

These drugs are increasingly talked about as something people might take for years or even indefinitely. That raises questions for me about what happens when someone cannot afford them anymore, when supply changes, when side effects become an issue or when a person simply does not want to stay on a medication for life.

If stopping leads not just to regain but to a fairly rapid rebound, it feels less like a temporary aid and more like something that is very hard to step away from once started. That sits oddly with how casually they are sometimes discussed.

AIBU to think the real issue here is not that people regain weight after stopping, but whether we are quietly normalising a treatment that may be difficult to discontinue once begun? Or is this simply the reality of managing a chronic condition?

A woman, wearing bright red nail polish and unbuttoned blue jeans, injects herself into the skin and soft tissue of her lower abdomen with an obesity jab pen.

People coming off weight-loss injections risk fast weight gain

Overweight people shed large amounts on jabs but gain 0.8 kg a month on average once off them, study shows.

https://www.bbc.co.uk/news/articles/c050ljnrv2qo

OP posts:
Thread gallery
14
velvetgeranium · 03/02/2026 10:29

Alltheyellowbirds · 03/02/2026 10:25

@velvetgeranium Why would you lose more muscle than on any other diet?

I don't know, but that is what the studies have found.

SilenceInside · 03/02/2026 10:34

There has been a variety of outcomes found from the results of the GLP1 clinical trials wrt muscle mass lost. The overall conclusion is not yet clear imo, and certainly the advice to eat enough protein and do some exercise is sensible for any weight loss approach. If you are older and already frail then that's particularly important if you are losing weight, with or without GLP1s.

Crikeyalmighty · 03/02/2026 10:36

Gingercar · 28/01/2026 18:15

I think it’s incredibly naive to think that you’re going to stroll off into the sunset without working very hard to maintain a weight loss. I’m on WLI and hope to drop them at the end. Most of my “naturally slim” friends work very hard at staying slim. I want to be like them - keeping an eye on my weight and reining myself in if need be. I definitely don’t want to stay on the drugs, despite having had no side effects whatsoever. I was obese, I’m not any longer. I was prediabetic, I’m not any more. I had high blood pressure and cholesterol, I don’t any more. I hope I can do it myself. I’ve been able to eat pretty normally on WLI l, I didn’t get full and had “food noise” so I hope I got used to using willpower and eating sensibly as much as the drugs.

And to me that’s the difference - there’s no logical reason to gain much if your habits and portions have changed by using WLI and you were still eating a fair bit on WLI , and it’s why I don’t think massive suppression for long periods is a great idea - because it’s not changing habits or diet in a long term sustainable way. Yes I have tried them, yes I did lose some purely by the fact I felt nauseous and had heartburn 4 days week so hardly ate, no I’m not on them now and have still lost weight by sticking to the principles, more water, more herbal tea, more protein, far less carb, far more veg and salad and as little sugar as possible - I realise now where I was going wrong before ( and I’m 64) - a lack of consistency that really needed months and months and months and although I ate well quality wise, my evening meals were way too big .

godmum56 · 03/02/2026 11:06

velvetgeranium · 03/02/2026 10:23

But it's not the worst thing that people can say about WLI. For starters, there are the life-affecting conditions currently listed by the pharmaceutical companies that make them. Gastroparesis, pancreatitis, bowel blockages, gallbladder problems, and acute kidney problems, and ileus, or intestinal paralysis; there is also NAION, sudden and complete vision loss, not yet listed as I understand it.

Obviously, if you are morbidly obese, then the benefits outweigh the risks. But if you (general you) are just sick of dieting to keep your weight down, and you have to stop taking them because you have side effects you find hard to live with or you can't afford them currently, or you are unlucky enough to be one of the people who had a severe adverse effect, then you regain the weight (and have in the meantime lost muscle and bone, which are hard to rebuild when older or unwell) four times faster than if you'd lost it by diet alone. Which is what this thread was supposed to be about.

Perhaps you don't have any side effects to mention, and you are lucky enough to not pick up something from the adverse effect list whilst on them, but you can't afford them currently any more, so you go off them. You've gone off them, regained most of the weight, lost more muscle than people who have gone on regular diets and regained more fat in your body composition, if not on the scale (ie more muscle lost, and more fat regained than regular dieters, as studies have shown). Each time someone goes back on them, and loses some weight again, they have again also lost more muscle and bone than if they'd just dieted...

It's going to take years for the real-world data to come in on the serious adverse effects per thousand of population on them, but having read stories from icu doctors about GLP-1 patients in their twenties having to have a colostomy bag for life after a bowel blockage, I would not want to risk that happening, even if it is one in a thousand or more chance.

indeed. But all this stuff is only relevant to the people weighing up whether the risk is worth the outcome for them. If you are, as the OP seems to be, someone who does not want to use WLI's themselves, which again, fine I don't choose them either, why are they "uneasy" about the choices of others?

Wickedlittledancer · 03/02/2026 11:12

godmum56 · 03/02/2026 11:06

indeed. But all this stuff is only relevant to the people weighing up whether the risk is worth the outcome for them. If you are, as the OP seems to be, someone who does not want to use WLI's themselves, which again, fine I don't choose them either, why are they "uneasy" about the choices of others?

It’s curtain twitching at its finest isn’t it. I have made an educated decision on my health, it is supported by my gp; why any random thinks their views are relevant to anyone on them, when they themselves are not, either as not eligible or can’t afford and feel duty bound to obsessively post negative comments Just in case we are not just fat but also stupid beats me,

well it doesn’t; and I would be interested if the op and her fan girl posted something relevant, but everything they post is either totally unbalanced, or in relation to wider weight loss.

there is no comments to the macro benefits,nothing to balance the negativity. Our feedback is you’re not on them, you either don’t want them or can’t get your hands on them, sad for you in the latter case, but unless you post something balanced and remotely interesting, not just havering on about environmental impact, the impact of weight loss in general or listing rare side effects on the leaflets then we have a discussion.

everything else is spitting in the wind.

godmum56 · 03/02/2026 13:10

Wickedlittledancer · 03/02/2026 11:12

It’s curtain twitching at its finest isn’t it. I have made an educated decision on my health, it is supported by my gp; why any random thinks their views are relevant to anyone on them, when they themselves are not, either as not eligible or can’t afford and feel duty bound to obsessively post negative comments Just in case we are not just fat but also stupid beats me,

well it doesn’t; and I would be interested if the op and her fan girl posted something relevant, but everything they post is either totally unbalanced, or in relation to wider weight loss.

there is no comments to the macro benefits,nothing to balance the negativity. Our feedback is you’re not on them, you either don’t want them or can’t get your hands on them, sad for you in the latter case, but unless you post something balanced and remotely interesting, not just havering on about environmental impact, the impact of weight loss in general or listing rare side effects on the leaflets then we have a discussion.

everything else is spitting in the wind.

This.

MO0N · 03/02/2026 13:11

velvetgeranium · 03/02/2026 10:29

I don't know, but that is what the studies have found.

My guess is that the muscle loss is directly related to rapid weight loss, the glp1s are an especially effective way to facilitate that rapid weight loss.

Alltheyellowbirds · 03/02/2026 13:19

MO0N · 03/02/2026 13:11

My guess is that the muscle loss is directly related to rapid weight loss, the glp1s are an especially effective way to facilitate that rapid weight loss.

Agreed, but that doesn’t make it different to any other rapid weight loss programme. PP was saying it’s specifically worse on WLI.

Disturbia81 · 03/02/2026 13:26

MO0N · 03/02/2026 13:11

My guess is that the muscle loss is directly related to rapid weight loss, the glp1s are an especially effective way to facilitate that rapid weight loss.

Exactly this
I lost muscle and went skinny fat after losing the weight without jabs.
Everyone who loses weight whatever the method should do weights.

soupyspoon · 03/02/2026 13:35

velvetgeranium · 03/02/2026 10:23

But it's not the worst thing that people can say about WLI. For starters, there are the life-affecting conditions currently listed by the pharmaceutical companies that make them. Gastroparesis, pancreatitis, bowel blockages, gallbladder problems, and acute kidney problems, and ileus, or intestinal paralysis; there is also NAION, sudden and complete vision loss, not yet listed as I understand it.

Obviously, if you are morbidly obese, then the benefits outweigh the risks. But if you (general you) are just sick of dieting to keep your weight down, and you have to stop taking them because you have side effects you find hard to live with or you can't afford them currently, or you are unlucky enough to be one of the people who had a severe adverse effect, then you regain the weight (and have in the meantime lost muscle and bone, which are hard to rebuild when older or unwell) four times faster than if you'd lost it by diet alone. Which is what this thread was supposed to be about.

Perhaps you don't have any side effects to mention, and you are lucky enough to not pick up something from the adverse effect list whilst on them, but you can't afford them currently any more, so you go off them. You've gone off them, regained most of the weight, lost more muscle than people who have gone on regular diets and regained more fat in your body composition, if not on the scale (ie more muscle lost, and more fat regained than regular dieters, as studies have shown). Each time someone goes back on them, and loses some weight again, they have again also lost more muscle and bone than if they'd just dieted...

It's going to take years for the real-world data to come in on the serious adverse effects per thousand of population on them, but having read stories from icu doctors about GLP-1 patients in their twenties having to have a colostomy bag for life after a bowel blockage, I would not want to risk that happening, even if it is one in a thousand or more chance.

Yes. I mean if I were you I would leave them well alone

Just step away from them and dont let that person who is forcing you to take them make you do something you dont want to do.

Have you thrown them away now?

godmum56 · 03/02/2026 13:37

soupyspoon · 03/02/2026 13:35

Yes. I mean if I were you I would leave them well alone

Just step away from them and dont let that person who is forcing you to take them make you do something you dont want to do.

Have you thrown them away now?

Happy Yeah Yeah GIF by Achievement Hunter

oh I want the laugh emoji have this instead

RufustheFactuaIReindeer · 03/02/2026 13:44

Two posters from the "How dare you discuss a downside to WLI! You are ignorant!" posse did engage with her briefly, later on

i have just checked back, i think you are referring to swing and I as i can only see our replies

if you are referring to me I would be grateful if you could point to anywhere i have said the above, as ive said exactly the opposite

unless you belong to the OP school of thought which seems to be ‘ i will twist everything said to me’ i am hoping not

MO0N · 03/02/2026 13:54

Alltheyellowbirds · 03/02/2026 13:19

Agreed, but that doesn’t make it different to any other rapid weight loss programme. PP was saying it’s specifically worse on WLI.

Yes!
It IS worse on WLI.
But only because WLI allows for much greater weight loss in a short space of time than other methods.

Wickedlittledancer · 03/02/2026 14:41

MO0N · 03/02/2026 13:54

Yes!
It IS worse on WLI.
But only because WLI allows for much greater weight loss in a short space of time than other methods.

Huh? Allows it v what? Plenty of ways to lose weight rapidly and the prescribers of the drugs are very clear, lose 1-2lbs a week which most do, if you lose too fast they stop prescribing.

godmum56 · 03/02/2026 14:44

Wickedlittledancer · 03/02/2026 14:41

Huh? Allows it v what? Plenty of ways to lose weight rapidly and the prescribers of the drugs are very clear, lose 1-2lbs a week which most do, if you lose too fast they stop prescribing.

yup, there are also warnings about getting gallstones but its the speed of the weightloss, not the use of WLI. Anybody who loses weight quickly by any method risks the same.

SwingTheMonkey · 03/02/2026 15:02

RufustheFactuaIReindeer · 03/02/2026 13:44

Two posters from the "How dare you discuss a downside to WLI! You are ignorant!" posse did engage with her briefly, later on

i have just checked back, i think you are referring to swing and I as i can only see our replies

if you are referring to me I would be grateful if you could point to anywhere i have said the above, as ive said exactly the opposite

unless you belong to the OP school of thought which seems to be ‘ i will twist everything said to me’ i am hoping not

Not sure I’ve said any of the above either tbh!

Wickedlittledancer · 03/02/2026 15:33

SwingTheMonkey · 03/02/2026 15:02

Not sure I’ve said any of the above either tbh!

Don’t think anyone said it, they just seem to be taking issues with anyone correcting inaccuracies, providing wider context.

so much of what’s posted is about general weight loss not specifically about tn4 jabs, I did chuckle at the posting of the rare side effects and raise an eyebrow at all the young people with colostomy bags due to the drugs.

youd not beleive it unless you read it with your own eyes, it feels like a deep seated all consuming envy of those on the meds.

RufustheFactuaIReindeer · 03/02/2026 18:03

SwingTheMonkey · 03/02/2026 15:02

Not sure I’ve said any of the above either tbh!

Yeah i don’t remember you saying that…

hopefully weve got it wrong and that poster is referring to someone else

pisses me off when i write what i think is a perfectly understandable post and it isn’t understood 😀

RufustheFactuaIReindeer · 03/02/2026 18:06

Wickedlittledancer · 03/02/2026 15:33

Don’t think anyone said it, they just seem to be taking issues with anyone correcting inaccuracies, providing wider context.

so much of what’s posted is about general weight loss not specifically about tn4 jabs, I did chuckle at the posting of the rare side effects and raise an eyebrow at all the young people with colostomy bags due to the drugs.

youd not beleive it unless you read it with your own eyes, it feels like a deep seated all consuming envy of those on the meds.

Dd stopped taking it when her insta feed was full of people who had gome blind when using it 🙄

Binus · 03/02/2026 20:45

RufustheFactuaIReindeer · 03/02/2026 18:03

Yeah i don’t remember you saying that…

hopefully weve got it wrong and that poster is referring to someone else

pisses me off when i write what i think is a perfectly understandable post and it isn’t understood 😀

One hopes so, otherwise it would be the third time in as many days that poster has accused someone she disagrees with of saying something she didn't. Hopefully you'll get more clarification than I did when I asked.

Wickedlittledancer · 03/02/2026 20:46

RufustheFactuaIReindeer · 03/02/2026 18:06

Dd stopped taking it when her insta feed was full of people who had gome blind when using it 🙄

Yes mine stopped using it when her insta feed was full of people who’s legs fell off when they took it.

Binus · 03/02/2026 20:50

Wickedlittledancer · 03/02/2026 20:46

Yes mine stopped using it when her insta feed was full of people who’s legs fell off when they took it.

One way to lose some weight, I suppose.

HereIGoOnceMore · 03/02/2026 21:07

True statistic. 75% of people who lose weight have chopped a limb off.

RufustheFactuaIReindeer · 03/02/2026 21:47

Wickedlittledancer · 03/02/2026 20:46

Yes mine stopped using it when her insta feed was full of people who’s legs fell off when they took it.

I did try telling her that it would be all over the papers and mainstream media if it was happening at those rates

not the legs…

SwingTheMonkey · 03/02/2026 21:52

HereIGoOnceMore · 03/02/2026 21:07

True statistic. 75% of people who lose weight have chopped a limb off.

What were the side effects of those who use this method of weigh loss, please? What percentage of those who lose a limb gain that weight straight back once the limb is gone? I’d never use this method of weigh loss but I feel the need to comment on it, nevertheless.

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