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Share your dilemmas and get honest opinions from other Mumsnetters.

Is it the begining of the end for Weight loss injections?

489 replies

BeginingoftheendforWLI · 02/01/2026 18:54

Just watched a report on BBC news, they did an item on a woman who had type 2 diabetes and was prescribed Mounjaro, doctors were impressed she managed to come off insulin within a month. She had some weightloss and now goes to the gym regularly.

Her doctor admitted that there was widespread concern in the medical field that people who were buying it privately for cosmetic reasons not for medical reasons could face some consequences in the future such as muscle growth and bone degeneration and lack of nutrition - they simply don't have this data at present.

Feel like this is going to be big news in the foreseeable future.

OP posts:
Arraminta · 02/01/2026 19:20

Only 2 days into the New Year and already I'm depressed again how ignorant and hard of thinking too many people are.

ThePeachHiker · 02/01/2026 19:21

You know if you’re thinner then it’s easy to exercise to build muscle and improve bone density. My family members who are on them appear to be exercising regularly as they feel more comfortable and confident to do so.

CharlotteStreetW1 · 02/01/2026 19:22

ColdAsAWitches · 02/01/2026 19:03

It's the beginning of the end, but only in the sense that the injections will be replaced by pills this year. One brand has already been approved by the FDA, and another is expected to be within 6 months.

Already here. I've just been prescribed with the tablets for Type II Diabetes.

(Feeling very ambivalent about it.)

devildeepbluesea · 02/01/2026 19:24

I have a good friend who is a senior medic, working in endocrinology- no idea how related this field is but I’m guessing at least a bit.

He maintains that WLIs are great for those who are morbidly obese and the danger of whose co-morbidities outweigh the unknown of WLIs.

However for people who only have a couple of stone to lose it could be cumulatively detrimental. The loss of muscle tone, bone density and who knows what else because we just don’t know yet, outweigh the health benefits of weighing less.

Personally I’d love to be 3 stone lighter but I’m aware that WLIs are likely to take away my appetite and consequently my ability to exercise regularly oreffectively. And that’s the reason I won’t bother. At 52 health is more important than appearance to me.

tobee · 02/01/2026 19:26

ColdAsAWitches · 02/01/2026 19:03

It's the beginning of the end, but only in the sense that the injections will be replaced by pills this year. One brand has already been approved by the FDA, and another is expected to be within 6 months.

Came here to say this. It's only the beginning for weight loss medications.

Hankunamatata · 02/01/2026 19:27

devildeepbluesea · 02/01/2026 19:24

I have a good friend who is a senior medic, working in endocrinology- no idea how related this field is but I’m guessing at least a bit.

He maintains that WLIs are great for those who are morbidly obese and the danger of whose co-morbidities outweigh the unknown of WLIs.

However for people who only have a couple of stone to lose it could be cumulatively detrimental. The loss of muscle tone, bone density and who knows what else because we just don’t know yet, outweigh the health benefits of weighing less.

Personally I’d love to be 3 stone lighter but I’m aware that WLIs are likely to take away my appetite and consequently my ability to exercise regularly oreffectively. And that’s the reason I won’t bother. At 52 health is more important than appearance to me.

This is exactly what im taking about benefits versus risk

tobee · 02/01/2026 19:28

MigGirl · 02/01/2026 19:06

I am concerned about the long term implications of these drugs. I agree they are a great tool and work really well for a lot of people, but I don't agree thay they should be available over the Internet and from online pharmacies. They are a medical drug and they should be monitored by a doctor, weather that be the NHS or private.

And yes I'm aware that would make them more expensive then they are now.

They are monitored by doctors. Doctors are the only ones who can prescribe them.

Yellowsubmarine55 · 02/01/2026 19:29

devildeepbluesea · 02/01/2026 19:24

I have a good friend who is a senior medic, working in endocrinology- no idea how related this field is but I’m guessing at least a bit.

He maintains that WLIs are great for those who are morbidly obese and the danger of whose co-morbidities outweigh the unknown of WLIs.

However for people who only have a couple of stone to lose it could be cumulatively detrimental. The loss of muscle tone, bone density and who knows what else because we just don’t know yet, outweigh the health benefits of weighing less.

Personally I’d love to be 3 stone lighter but I’m aware that WLIs are likely to take away my appetite and consequently my ability to exercise regularly oreffectively. And that’s the reason I won’t bother. At 52 health is more important than appearance to me.

You do realise that people taking the WLI do actually eat as well and shock horror exercise effectively.

DarkForces · 02/01/2026 19:29

devildeepbluesea · 02/01/2026 19:24

I have a good friend who is a senior medic, working in endocrinology- no idea how related this field is but I’m guessing at least a bit.

He maintains that WLIs are great for those who are morbidly obese and the danger of whose co-morbidities outweigh the unknown of WLIs.

However for people who only have a couple of stone to lose it could be cumulatively detrimental. The loss of muscle tone, bone density and who knows what else because we just don’t know yet, outweigh the health benefits of weighing less.

Personally I’d love to be 3 stone lighter but I’m aware that WLIs are likely to take away my appetite and consequently my ability to exercise regularly oreffectively. And that’s the reason I won’t bother. At 52 health is more important than appearance to me.

That's nice for him. I assume that he's on the committee who analyse the actual data and make decisions based on that?

Scarlettpixie · 02/01/2026 19:31

The level of ignorance on this topic from people with something to say about it is mind blowing.

OP why after reading an article saying how well someone was doing after taking MJ makes you think you think the fact that it may have a detrimental impact on the health of people taking it for cosmetic reasons is the beginning of the end? I don't get it. The vast majority of people taking it are those with genuine need who are being properly prescribed and are seeing real life changing improvements.

devildeepbluesea · 02/01/2026 19:31

Yellowsubmarine55 · 02/01/2026 19:29

You do realise that people taking the WLI do actually eat as well and shock horror exercise effectively.

It’s a well known side effect that they cause tiredness, FFS. We’re not talking in absolutes here. These are new drugs.

Youdontseehow · 02/01/2026 19:31

chellewillnotbebeaten · 02/01/2026 19:04

I agree - admittedly I don’t need wli but I have been very overweight in the past and would have probably snapped them up at the time - early to mid twenties I fried every fad diet, pharmacy only shakes, everything (heartbreak diet solved the issue in the end haha) BUT I do think they are poorly regulated/controlled…… people are injecting insulin when they are not diabetic! That’s so dangerous! (I work in healthcare and have seen devastating effects and death from incorrect insulin management for people that actually are diabetic). Then again, I smoke and ecig and I’m sure in years to come there will be consequences with that.

lol as if you work in health care coming away with 💩 like this.

if you do indeed work in health care, I assume you patrol the car parking or take the bins out?

Jackiepumpkinhead · 02/01/2026 19:32

chellewillnotbebeaten · 02/01/2026 19:04

I agree - admittedly I don’t need wli but I have been very overweight in the past and would have probably snapped them up at the time - early to mid twenties I fried every fad diet, pharmacy only shakes, everything (heartbreak diet solved the issue in the end haha) BUT I do think they are poorly regulated/controlled…… people are injecting insulin when they are not diabetic! That’s so dangerous! (I work in healthcare and have seen devastating effects and death from incorrect insulin management for people that actually are diabetic). Then again, I smoke and ecig and I’m sure in years to come there will be consequences with that.

It’s a bit concerning that you work in healthcare and think WLI are insulin. They absolutely are not and you shouldn’t be saying otherwise. Very dangerous.

devildeepbluesea · 02/01/2026 19:32

DarkForces · 02/01/2026 19:29

That's nice for him. I assume that he's on the committee who analyse the actual data and make decisions based on that?

You assume correct.

Squirrelchops1 · 02/01/2026 19:33

My muscles have never been so strong! Easy 60kg RDL this am, farmers carries with 50kg total etc
..

tobee · 02/01/2026 19:34

Personally I’d love to be 3 stone lighter but I’m aware that WLIs are likely to take away my appetite and consequently my ability to exercise regularly oreffectively. And that’s the reason I won’t bother. At 52 health is more important than appearance to me.

What? Losing your appetite affects your ability to exercise? You don't lose your appetite for a kick off.

I need to lose about three stone and that will help me to avoid weight related diabetes type 2, help with avoiding the joint problems that run in my family, and help lower my blood pressure that I already have.

Tulcan · 02/01/2026 19:35

MigGirl · 02/01/2026 19:06

I am concerned about the long term implications of these drugs. I agree they are a great tool and work really well for a lot of people, but I don't agree thay they should be available over the Internet and from online pharmacies. They are a medical drug and they should be monitored by a doctor, weather that be the NHS or private.

And yes I'm aware that would make them more expensive then they are now.

Are you? That’s nice of you.

What about the fact that the people who are prescribed them are not in tip top health in the first place? Just like all the other folks who are prescribed medication.

tobee · 02/01/2026 19:35

Op has not returned yet I see.

EdgeOfThirtySeven · 02/01/2026 19:35

CharlotteStreetW1 · 02/01/2026 19:22

Already here. I've just been prescribed with the tablets for Type II Diabetes.

(Feeling very ambivalent about it.)

(Feeling very ambivalent about it.)

Why?

Whoneedsanamesuggestion · 02/01/2026 19:35

I don't even use WLIs and hate seeing these fecking threads! Couldn't you at least keep it to the right board or just not? Lots of people seem to be losing weight using them and they all seem delighted. I am sure they are aware of the horror stories and have made the decision as grown ups to go ahead anyway. Leave them alone fgs! Nobody is forcing them into you

MigGirl · 02/01/2026 19:35

Ukefluke · 02/01/2026 19:12

If you are "concerned" dont take them. Simple.
Are you cobcerned about paracetamol use as well? Because there are more hospital admissions for that than for GLPs

I'm always wary of any drug I need to take, I have had to take a lot of medication over the years for health problems and I would never take anything I don't absolutely feel I need to. I'm currently on a much newer drug then WLI and the long term side effects are as yet unknown. I really wish I didn't need to take anything. But I can't function without it so have no choice.

Yes I'm concerned about paracetamol overdose as well especially when there is a very simple way to stop this by adding in the correct amount of antidote into each tablet like they do in some countries.

You can never take anything without there being a side effect or risk and its weather the benefits outway the risk. But still there isn't enough regulation around these drugs, as I do know people who are taking then but don't seem to understand that there could be side effects from them. That's where more oversight by a medical professional comes in to make sure people know what they are taking first and how to use them properly.

vodkaredbullgirl · 02/01/2026 19:36

tobee · 02/01/2026 19:35

Op has not returned yet I see.

Another dump and run

HRTQueen · 02/01/2026 19:39

I’m so touched that so many are so concerned about all the previous obese people and the medication we are taking

I was never aware of how concerned people were before about fat people and I mistakenly took it as judgement

it’s really heart warming 😊

Funnywonder · 02/01/2026 19:39

Her doctor admitted that there was widespread concern in the medical field that people who were buying it privately for cosmetic reasons not for medical reasons could face some consequences in the future such as muscle growth and bone degeneration and lack of nutrition - they simply don't have this data at present.

This is what stands out for me in the OP. People using the injections privately ARE doing it for medical reasons. Or health reasons if you will. It’s not all about fitting into a size 8 dress FFS.

MigGirl · 02/01/2026 19:40

Tulcan · 02/01/2026 19:35

Are you? That’s nice of you.

What about the fact that the people who are prescribed them are not in tip top health in the first place? Just like all the other folks who are prescribed medication.

I'm not talking about people who are prescribed them by a medical doctor, I'm referring to those buying them over the Internet.

Being prescribe a drug by a doctor is totally different as they will have weighed up the befits vs the risks for that individual first.