I went self employed when DD started preschool so that I could work around her hours. Then when she turned 4 , XH walked out, so I then had to build my business up a lot quicker and make it full time.
I relied on after school club, or clubs run at the school like choir, frisbee etc that meant picking her up later, or other clubs, with a friend taking her there, such as Rainbows/Brownies, gymnastics, dance classes, anything that meant I could pick her up an hour later. I alternated swimming lessons with a friend so we could work a long day EOW. I felt sorry for DD at times that she could never just come home from school, but needs must.
During holidays, when she was very young, I relied on my mum and swapping childcare with a friend. As the business grew I needed more help.
We live in an area with no childminders, no holiday clubs etc, so it was very hard at times. There was the odd club by her dance group that ran 10-2 for 3 days, so I could try and schedule work around that.
During holidays, as she grew up, she would go to my mum on a Sunday night and come back on Weds evening, so that I could go to clients Mon-Weds and work at home Thurs-Fri. I was very lucky that my mum could do this, but mum could help more as DD got older, and was unable to provide childcare when DD was a baby. I would also take 2 separate breaks of 3-4 nights at the start and end of August.
Since covid, I have worked at home full time and it hasn't been a problem, although DD is now 16 and leaving school.